Diagnostic accuracy and screening statistics — branching viva

Opening (candidate)

I would treat this as a structured appraisal rather than a result handover. First I would judge the study's validity with QUADAS-2 before trusting the headline sensitivity and specificity, then I would ask whether the quoted positive predictive value applies to the community population, and finally I would work out how the test's likelihood ratio moves the probability of disease in an individual child. ^{[9] [4]}