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Paeds Vivasfetal-neonatal-and-perinatal

Paeds Vivas · fetal-neonatal-and-perinatal

Apnoea of prematurity — structured oral (viva)

Branching structured oral on a preterm infant with recurrent apnoea, testing definition, pathophysiology, caffeine pharmacology, and exclusion of secondary causes.

branching clinical structured oral2 min readVerification in progress

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
A 4-day-old infant, born at 26 weeks' gestation at 780 g, is on continuous monitoring for recurrent apnoea. Over the last 12 hours the events have increased in frequency from three to twelve per shift, each lasting 20 to 30 seconds with desaturation to 70 percent and bradycardia to 60. The infant was previously stable on caffeine citrate at 5 mg/kg per day.

Branch 1 — Definition and classification

Examiner: "What is apnoea of prematurity, and how do you define an event?" Candidate: Apnoea of prematurity is a developmental disorder of respiratory control in infants born before 37 weeks, presenting after the first 24 hours. An event is defined as a cessation of breathing for 20 seconds or longer, or a shorter pause with bradycardia below 80 beats per minute, central cyanosis, or desaturation below 80 to 85 percent. [2]

Examiner: "Name the three types. Which is most common?" Candidate: Central apnoea is absent effort and airflow from loss of neural drive; obstructive apnoea preserves effort but loses airflow through upper-airway collapse; and mixed apnoea is a central pause followed by obstruction. Mixed is the most common type, which is why continuous positive airway pressure is often required alongside caffeine. [2]

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References2ShowHide
  1. [1]Schmidt B, Roberts RS, Davis P, et al Caffeine therapy for apnea of prematurity. N Engl J Med, 2006.PMID 16707748
  2. [2]Erickson G, Dobson NR, Hunt CE Immature control of breathing and apnea of prematurity: the known and unknown. J Perinatol, 2021.PMID 33712716
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