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Paeds Topicspreventive-and-community-paediatrics

Paeds · preventive-and-community-paediatrics

Screening test principles in children

Also known as Paediatric screening principles · Wilson Jungner children · Population screening paediatrics · False positive screening children · Predictive value low prevalence

Fellowship guide to screening test principles in children: programme criteria, sensitivity specificity and PPV in low prevalence, false-positive harm, two-step pathways, consent, net benefit, and ANZ/UK/US/Canada governance differences without duplicating bloodspot, hearing or developmental tool chapters.

high24 referencesUpdated 11 July 202615 min readVerification in progress

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Target exams

RACP General PaediatricsMRCPCHABPRCPSC Pediatrics

Red flags

  • Screening offered with no timely confirmatory or treatment pathway
  • Positive screen treated as a diagnosis without confirmation
  • Negative screen used to dismiss new symptoms
  • Low-prevalence positive result assumed to mean disease is likely
  • Commercial multi-disease panel sold as population screening without net-benefit evidence
  • Lost follow-up after a positive newborn or school screen
  • Coercive consent that hides false-positive and residual-risk language

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

preventive-medical-homecommunity-schooloutpatientdelivery-roomnicuwardrural-remotetelehealth

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-history-managementmrcpch-communicationrcpsc-structured-oral

Board mappings

  • General and Community Paediatrics
  • Clinical Sciences — Epidemiology and evidence-based practice
  • Current 2026 PREP curriculum — Learning Objective related to preventive health and screening in general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 6: Clinical management – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 12: Communication with patients, families, and health professionals
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 15: Essential general paediatrics
  • Clinical Applications
  • Evidence-based practice
  • Long Cases
  • Short Cases
  • 2. Professional skills and knowledge: Communication
  • 4. Professional skills and knowledge: Patient management
  • 5. Health promotion and illness prevention
  • 7. Patient safety, including safe prescribing
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • History
  • Communication
  • Clinical
  • General Pediatrics Content Outline — Domain 1: Preventive Pediatrics/Well-Child Care
  • General Pediatrics Content Outline — research and evidence-based practice
  • General Pediatrics EPA 1: Provide a Medical Home for Well Children of All Ages
  • General Pediatrics EPA 3: Provide Well-Child Care and Anticipatory Guidance
  • Patient Care 1: History and Physical Examination
  • Patient Care 5: Patient Management
  • Medical Knowledge 1: Clinical Reasoning
  • Systems-Based Practice 3: System Navigation for Patient Centered Care – Coordination of Care
  • Practice-Based Learning and Improvement
  • Health Advocate
  • Medical Expert
  • Communicator
  • Scholar
  • Pediatrics: Foundations EPA — Providing well-child care including preventive screening assessment
  • Pediatrics: Core EPA — Managing preventive care across the paediatric age spectrum
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Study tools

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Saved on this device.

Practise this topic

  • Short-answer question1
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Target exams

RACP General PaediatricsMRCPCHABPRCPSC Pediatrics

Red flags

  • Screening offered with no timely confirmatory or treatment pathway
  • Positive screen treated as a diagnosis without confirmation
  • Negative screen used to dismiss new symptoms
  • Low-prevalence positive result assumed to mean disease is likely
  • Commercial multi-disease panel sold as population screening without net-benefit evidence
  • Lost follow-up after a positive newborn or school screen
  • Coercive consent that hides false-positive and residual-risk language

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

preventive-medical-homecommunity-schooloutpatientdelivery-roomnicuwardrural-remotetelehealth

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-history-managementmrcpch-communicationrcpsc-structured-oral

Board mappings

  • General and Community Paediatrics
  • Clinical Sciences — Epidemiology and evidence-based practice
  • Current 2026 PREP curriculum — Learning Objective related to preventive health and screening in general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 6: Clinical management – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 12: Communication with patients, families, and health professionals
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 15: Essential general paediatrics
  • Clinical Applications
  • Evidence-based practice
  • Long Cases
  • Short Cases
  • 2. Professional skills and knowledge: Communication
  • 4. Professional skills and knowledge: Patient management
  • 5. Health promotion and illness prevention
  • 7. Patient safety, including safe prescribing
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • History
  • Communication
  • Clinical
  • General Pediatrics Content Outline — Domain 1: Preventive Pediatrics/Well-Child Care
  • General Pediatrics Content Outline — research and evidence-based practice
  • General Pediatrics EPA 1: Provide a Medical Home for Well Children of All Ages
  • General Pediatrics EPA 3: Provide Well-Child Care and Anticipatory Guidance
  • Patient Care 1: History and Physical Examination
  • Patient Care 5: Patient Management
  • Medical Knowledge 1: Clinical Reasoning
  • Systems-Based Practice 3: System Navigation for Patient Centered Care – Coordination of Care
  • Practice-Based Learning and Improvement
  • Health Advocate
  • Medical Expert
  • Communicator
  • Scholar
  • Pediatrics: Foundations EPA — Providing well-child care including preventive screening assessment
  • Pediatrics: Core EPA — Managing preventive care across the paediatric age spectrum
The fellowship answer

Screening is a programme that finds unrecognised disease or risk in well children early enough that action improves outcomes. It is not a laboratory result and not a diagnosis. Before you offer any screen, check five things: the condition matters; a good test exists; early treatment helps; the confirmatory and treatment pathway is ready; and benefits outweigh harms after false positives and overdiagnosis are counted. In low-prevalence settings, even a “good” test produces mostly false positives among positive results—so you must speak in predictive values, complete follow-up, and never treat a screen as the final word. [1] [2] [4] [5]

Overview & Definition

A parent holds a healthy newborn and asks why the heel-prick and hearing check are needed “when nothing is wrong.” The clinical answer is simple: some serious conditions start quietly. If you wait for symptoms, the chance to protect the brain, hearing or metabolism may already be smaller. Screening means offering a test to children who look well, aiming to find disease or high risk early enough that a planned action improves outcome. [4] [22]

That sentence hides three traps. First, screening is not diagnostic testing of a sick child. Second, a positive screen is a flag, not a label. Third, a negative screen reduces risk; it does not make risk zero. Examiners listen for those three distinctions. [4] [5] [17]

A screening pathway is the full chain: invitation and information, consent, the index test, interpretation, timely confirmatory testing, treatment or surveillance, and programme audit. If any link is missing, the “screen” is incomplete even when the swab or blot looks perfect. [2] [3]

Screening is a programme, not a test

A laboratory assay, questionnaire or hearing machine is only one step. Benefit appears only when true positives reach effective care in time, and when harms from false positives and overdiagnosis are controlled. [2] [21]

Five questions before you offer any paediatric screen

  1. 1

    Is the condition important?

    Serious enough, early enough, and common enough in this group to justify looking.

  2. 2

    Is there an acceptable accurate test?

    Workable in real children, with known sensitivity and specificity.

  3. 3

    Does early action help?

    Treatment or prevention started after screen must beat waiting for symptoms.

  4. 4

    Is the pathway ready?

    Confirmatory tests, specialists, drugs and follow-up must exist now—not next year.

  5. 5

    Is net benefit clear after harms?

    Count false positives, anxiety, overdiagnosis, cost and equity—not only true positives found.

[1] [2] [3] [12]
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References24ShowHide
  1. [1]Andermann A Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years Bulletin of the World Health Organization, 2008.PMID 18438522
  2. [2]Dobrow MJ Consolidated principles for screening based on a systematic review and consensus process CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018.PMID 29632037
  3. [3]Harris R Reconsidering the criteria for evaluating proposed screening programs: reflections from 4 current and former members of the U.S. Preventive services task force Epidemiologic reviews, 2011.PMID 21666224
  4. [4]Grimes DA Uses and abuses of screening tests Lancet (London, England), 2002.PMID 11897304
  5. [5]Akobeng AK Understanding diagnostic tests 1: sensitivity, specificity and predictive values Acta paediatrica (Oslo, Norway : 1992), 2007.PMID 17407452
  6. [6]Akobeng AK Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice Acta paediatrica (Oslo, Norway : 1992), 2007.PMID 17306009
  7. [7]Akobeng AK Understanding diagnostic tests 3: Receiver operating characteristic curves Acta paediatrica (Oslo, Norway : 1992), 2007.PMID 17376185
  8. [8]Deeks JJ Diagnostic tests 4: likelihood ratios BMJ (Clinical research ed.), 2004.PMID 15258077
  9. [9]Fagan TJ Letter: Nomogram for Bayes's theorem The New England journal of medicine, 1975.PMID 1143310
  10. [10]Pauker SG The threshold approach to clinical decision making The New England journal of medicine, 1980.PMID 7366635
  11. [11]Maxim LD Screening tests: a review with examples Inhalation toxicology, 2014.PMID 25264934
  12. [12]Barratt A Users' guides to the medical literature: XVII. How to use guidelines and recommendations about screening. Evidence-Based Medicine Working Group JAMA, 1999.PMID 10359392
  13. [13]Jaeschke R Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group JAMA, 1994.PMID 8309035
  14. [14]Tluczek A Psychosocial consequences of false-positive newborn screens for cystic fibrosis Qualitative health research, 2011.PMID 20852016
  15. [15]Størdal K Overtesting and overtreatment-statement from the European Academy of Paediatrics (EAP) European journal of pediatrics, 2019.PMID 31506723
  16. [16]Jankauskaite L Overuse of medical care in paediatrics: A survey from five countries in the European Academy of Pediatrics Frontiers in pediatrics, 2022.PMID 36177454
  17. [17]Newman-Toker DE A unified conceptual model for diagnostic errors: underdiagnosis, overdiagnosis, and misdiagnosis Diagnosis (Berlin, Germany), 2014.PMID 28367397
  18. [18]Bossuyt PM STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies BMJ (Clinical research ed.), 2015.PMID 26511519
  19. [19]Whiting PF QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies Annals of internal medicine, 2011.PMID 22007046
  20. [20]Kemper AR Decision-making process for conditions nominated to the recommended uniform screening panel: statement of the US Department of Health and Human Services Secretary's Advisory Committee on Heritable Disorders in Newborns and Children Genetics in medicine : official journal of the American College of Medical Genetics, 2014.PMID 23907646
  21. [21]Goldenberg AJ Evaluating Harms in the Assessment of Net Benefit: A Framework for Newborn Screening Condition Review Maternal and child health journal, 2016.PMID 26833040
  22. [22]Schielen PCJI Historical Appreciation of World Health Organization's Public Health Paper-34: Principles and Practice of Screening for Disease, by Max Wilson and Gunnar Jungner International journal of neonatal screening, 2025.PMID 40700048
  23. [23]Grosse SD Screening for Neonatal Hyperbilirubinemia-First Do No Harm? JAMA pediatrics, 2019.PMID 31107538
  24. [24]Bordini BJ Overcoming Diagnostic Errors in Medical Practice The Journal of pediatrics, 2017.PMID 28336147

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