Paeds · paediatric-dermatology
Molluscum contagiosum and viral warts
Also known as molluscum contagiosum · water warts · viral warts · verrucae · verruca vulgaris · common warts · plantar warts · plane warts
Two of the commonest benign, self-limiting viral skin infections of childhood — molluscum contagiosum (a poxvirus causing pearly umbilicated papules) and viral warts (human papillomavirus causing rough keratotic papules) — both managed by default with expectant care and treated actively only when symptomatic, spreading or bothersome.
On this page
Study tools
Your progress
Saved on this device.
Practise this topic
Target exams
Red flags
- extensive, giant or confluent molluscum, or onset in early infancy, suggesting underlying immunodeficiency such as HIV or DOCK8
- warts that are rapidly growing, bleeding, ulcerated or fixed, which may be verrucous or squamous cell carcinoma rather than a wart — especially in an immunosuppressed child
- a recalcitrant periungual or plantar lesion that resists 12 weeks of standard therapy and looks atypical
- ano-genital molluscum or warts whose distribution or history raises safeguarding concern
- secondary bacterial infection with spreading cellulitis or impetiginisation around picked lesions
Life stages
Care settings
Clinical exam formats
Board mappings
- recognise and manage molluscum contagiosum and viral warts in children
- explain expectant versus active treatment
- apply stepwise topical and physical therapy
- recognise immunodeficiency in atypical disease
- interpret molluscum and wart evidence and trial limitations
- high-yield: molluscum morphology and poxvirus, HPV types, stepwise treatment ladder, expectant management, red flags for immunodeficiency
- short-case assessment of a child with molluscum or viral warts and parental counselling
- common skin infections — molluscum contagiosum and viral warts: diagnosis and management
- molluscum (poxvirus, umbilicated papule) and warts (HPV types, koilocytes); conservative-first management
- assess and counsel the parents of a child with molluscum or warts
- molluscum contagiosum and viral warts — diagnosis and management
- milestone: diagnoses clinically, defaults to conservative care, applies stepwise therapy, recognises immunodeficiency red flags
- common paediatric dermatology — molluscum and warts: recognise, counsel and manage
Overview & Definition
A parent brings a four-year-old to clinic worried about a cluster of small, shiny, pearly bumps in the armpit that have spread over several months, and a rough knob on the side of a thumb that will not go away. Both are everyday primary-care presentations, and both are benign, self-limiting viral infections of the skin. Molluscum contagiosum is a cutaneous infection by a DNA poxvirus that produces smooth, dome-shaped, umbilicated papules, while viral warts are benign epidermal growths driven by human papillomavirus that produce rough, keratotic papules. [2]
The unifying principle is that both conditions are common, contagious but harmless, and resolve spontaneously through cell-mediated immunity in the great majority of children. The central clinical decision is therefore not how aggressively to eradicate them but whether to treat at all: expectant, conservative management is the default, and active treatment is reserved for lesions that are symptomatic, spreading, or genuinely bothersome. A 2015 UK community cohort showed that molluscum has a measurable but modest effect on quality of life, framing reassurance and watchful waiting as a legitimate first choice rather than a default of omission. [3]
References12ShowHide
- [1]Olsen JR, Gallacher J, Piguet V, et al Epidemiology of molluscum contagiosum in children: a systematic review Fam Pract, 2014.PMID 24297468
- [2]Schaffer JV, Berger EM Molluscum Contagiosum JAMA Dermatol, 2016.PMID 27627044
- [3]Olsen JR, Gallacher J, Finlay AY, et al Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study Lancet Infect Dis, 2015.PMID 25541478
- [4]Giner-Soriano M, Teixidó C, Marsal JR, et al Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% Potassium hydroxide for molluscum contagiosum treatment in children J Dermatolog Treat, 2019.PMID 30668179
- [5]Sugarman JL, Hebert A, Browning JC, et al Berdazimer gel for molluscum contagiosum: An integrated analysis of 3 randomized controlled trials J Am Acad Dermatol, 2024.PMID 37804936
- [6]Paller AS, Green LJ, Silverberg N, et al Berdazimer gel for molluscum contagiosum in patients with atopic dermatitis Pediatr Dermatol, 2024.PMID 38413239
- [7]Chao YC, Ko MJ, Tsai WC, et al Comparative efficacy of treatments for molluscum contagiosum: A systematic review and network meta-analysis J Dtsch Dermatol Ges, 2023.PMID 37199262
- [8]Kwok CS, Gibbs S, Bennett C, et al Topical treatments for cutaneous warts Cochrane Database Syst Rev, 2012.PMID 22972052
- [9]Stefanaki C, Lagogiani I, Kouris A, et al Cryotherapy versus imiquimod 5% cream combined with a keratolytic lotion in cutaneous warts in children: A randomized study J Dermatolog Treat, 2016.PMID 25886088
- [10]Egawa N, Doorbar J The low-risk papillomaviruses Virus Res, 2017.PMID 28040475
- [11]Stamuli E, Cockayne S, Hewitt C, et al Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial) J Foot Ankle Res, 2012.PMID 22369511
- [12]Loo SK, Tang WY Warts (non-genital) BMJ Clin Evid, 2014.PMID 24921240