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Paeds Topicspaediatric-dermatology

Paeds · paediatric-dermatology

Molluscum contagiosum and viral warts

Also known as molluscum contagiosum · water warts · viral warts · verrucae · verruca vulgaris · common warts · plantar warts · plane warts

Two of the commonest benign, self-limiting viral skin infections of childhood — molluscum contagiosum (a poxvirus causing pearly umbilicated papules) and viral warts (human papillomavirus causing rough keratotic papules) — both managed by default with expectant care and treated actively only when symptomatic, spreading or bothersome.

high12 referencesUpdated 16 July 202619 min readVerification in progress

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Target exams

RACP DWERACP DCEMRCPCH TheoryABP General Pediatrics

Red flags

  • extensive, giant or confluent molluscum, or onset in early infancy, suggesting underlying immunodeficiency such as HIV or DOCK8
  • warts that are rapidly growing, bleeding, ulcerated or fixed, which may be verrucous or squamous cell carcinoma rather than a wart — especially in an immunosuppressed child
  • a recalcitrant periungual or plantar lesion that resists 12 weeks of standard therapy and looks atypical
  • ano-genital molluscum or warts whose distribution or history raises safeguarding concern
  • secondary bacterial infection with spreading cellulitis or impetiginisation around picked lesions

Life stages

infanttoddlerpreschoolschool-ageadolescent

Care settings

outpatientcommunity-schooltelehealthed-acuterural-remote

Clinical exam formats

written-only

Board mappings

  • recognise and manage molluscum contagiosum and viral warts in children
  • explain expectant versus active treatment
  • apply stepwise topical and physical therapy
  • recognise immunodeficiency in atypical disease
  • interpret molluscum and wart evidence and trial limitations
  • high-yield: molluscum morphology and poxvirus, HPV types, stepwise treatment ladder, expectant management, red flags for immunodeficiency
  • short-case assessment of a child with molluscum or viral warts and parental counselling
  • common skin infections — molluscum contagiosum and viral warts: diagnosis and management
  • molluscum (poxvirus, umbilicated papule) and warts (HPV types, koilocytes); conservative-first management
  • assess and counsel the parents of a child with molluscum or warts
  • molluscum contagiosum and viral warts — diagnosis and management
  • milestone: diagnoses clinically, defaults to conservative care, applies stepwise therapy, recognises immunodeficiency red flags
  • common paediatric dermatology — molluscum and warts: recognise, counsel and manage
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  • Short-answer question1
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Target exams

RACP DWERACP DCEMRCPCH TheoryABP General Pediatrics

Red flags

  • extensive, giant or confluent molluscum, or onset in early infancy, suggesting underlying immunodeficiency such as HIV or DOCK8
  • warts that are rapidly growing, bleeding, ulcerated or fixed, which may be verrucous or squamous cell carcinoma rather than a wart — especially in an immunosuppressed child
  • a recalcitrant periungual or plantar lesion that resists 12 weeks of standard therapy and looks atypical
  • ano-genital molluscum or warts whose distribution or history raises safeguarding concern
  • secondary bacterial infection with spreading cellulitis or impetiginisation around picked lesions

Life stages

infanttoddlerpreschoolschool-ageadolescent

Care settings

outpatientcommunity-schooltelehealthed-acuterural-remote

Clinical exam formats

written-only

Board mappings

  • recognise and manage molluscum contagiosum and viral warts in children
  • explain expectant versus active treatment
  • apply stepwise topical and physical therapy
  • recognise immunodeficiency in atypical disease
  • interpret molluscum and wart evidence and trial limitations
  • high-yield: molluscum morphology and poxvirus, HPV types, stepwise treatment ladder, expectant management, red flags for immunodeficiency
  • short-case assessment of a child with molluscum or viral warts and parental counselling
  • common skin infections — molluscum contagiosum and viral warts: diagnosis and management
  • molluscum (poxvirus, umbilicated papule) and warts (HPV types, koilocytes); conservative-first management
  • assess and counsel the parents of a child with molluscum or warts
  • molluscum contagiosum and viral warts — diagnosis and management
  • milestone: diagnoses clinically, defaults to conservative care, applies stepwise therapy, recognises immunodeficiency red flags
  • common paediatric dermatology — molluscum and warts: recognise, counsel and manage

Overview & Definition

A parent brings a four-year-old to clinic worried about a cluster of small, shiny, pearly bumps in the armpit that have spread over several months, and a rough knob on the side of a thumb that will not go away. Both are everyday primary-care presentations, and both are benign, self-limiting viral infections of the skin. Molluscum contagiosum is a cutaneous infection by a DNA poxvirus that produces smooth, dome-shaped, umbilicated papules, while viral warts are benign epidermal growths driven by human papillomavirus that produce rough, keratotic papules. [2]

The unifying principle is that both conditions are common, contagious but harmless, and resolve spontaneously through cell-mediated immunity in the great majority of children. The central clinical decision is therefore not how aggressively to eradicate them but whether to treat at all: expectant, conservative management is the default, and active treatment is reserved for lesions that are symptomatic, spreading, or genuinely bothersome. A 2015 UK community cohort showed that molluscum has a measurable but modest effect on quality of life, framing reassurance and watchful waiting as a legitimate first choice rather than a default of omission. [3]

What are molluscum contagiosum and viral warts in one sentence?Molluscum contagiosum (a poxvirus) and viral warts (human papillomavirus) are two of the commonest benign, self-limiting viral skin infections of childhood; both are managed by default with expectant care and treated actively — with salicylic acid or cryotherapy for warts, and cantharidin, potassium hydroxide or berdazimer for molluscum — only when lesions are symptomatic, spreading or bothersome. [2]
Extensive or giant lesions may flag immunodeficiencyA child with extensive, confluent or giant molluscum, or warts that are refractory, atypical, bleeding or ulcerated — especially in early infancy or an immunosuppressed host — should be assessed for underlying immunodeficiency (HIV, DOCK8 deficiency, combined immunodeficiency) and for malignancy mimics (verrucous or squamous cell carcinoma), not merely treated more aggressively. [2]
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References12ShowHide
  1. [1]Olsen JR, Gallacher J, Piguet V, et al Epidemiology of molluscum contagiosum in children: a systematic review Fam Pract, 2014.PMID 24297468
  2. [2]Schaffer JV, Berger EM Molluscum Contagiosum JAMA Dermatol, 2016.PMID 27627044
  3. [3]Olsen JR, Gallacher J, Finlay AY, et al Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study Lancet Infect Dis, 2015.PMID 25541478
  4. [4]Giner-Soriano M, Teixidó C, Marsal JR, et al Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% Potassium hydroxide for molluscum contagiosum treatment in children J Dermatolog Treat, 2019.PMID 30668179
  5. [5]Sugarman JL, Hebert A, Browning JC, et al Berdazimer gel for molluscum contagiosum: An integrated analysis of 3 randomized controlled trials J Am Acad Dermatol, 2024.PMID 37804936
  6. [6]Paller AS, Green LJ, Silverberg N, et al Berdazimer gel for molluscum contagiosum in patients with atopic dermatitis Pediatr Dermatol, 2024.PMID 38413239
  7. [7]Chao YC, Ko MJ, Tsai WC, et al Comparative efficacy of treatments for molluscum contagiosum: A systematic review and network meta-analysis J Dtsch Dermatol Ges, 2023.PMID 37199262
  8. [8]Kwok CS, Gibbs S, Bennett C, et al Topical treatments for cutaneous warts Cochrane Database Syst Rev, 2012.PMID 22972052
  9. [9]Stefanaki C, Lagogiani I, Kouris A, et al Cryotherapy versus imiquimod 5% cream combined with a keratolytic lotion in cutaneous warts in children: A randomized study J Dermatolog Treat, 2016.PMID 25886088
  10. [10]Egawa N, Doorbar J The low-risk papillomaviruses Virus Res, 2017.PMID 28040475
  11. [11]Stamuli E, Cockayne S, Hewitt C, et al Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial) J Foot Ankle Res, 2012.PMID 22369511
  12. [12]Loo SK, Tang WY Warts (non-genital) BMJ Clin Evid, 2014.PMID 24921240

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