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Paeds Topicsgastroenterology-hepatology-and-nutrition

Paeds · gastroenterology-hepatology-and-nutrition

Acute vomiting in infants and children

Also known as Vomiting in children · Emesis in infants · Bilious vomiting · Projectile vomiting · Non-bilious vomiting · The vomiting child

Fellowship guide to acute vomiting in infants and children: the bilious-vomiting surgical emergency, the age-based differential from malrotation and pyloric stenosis to gastroenteritis and raised intracranial pressure, the vomiting reflex and its four afferent triggers, clinical dehydration assessment, oral rehydration and the role of ondansetron, the harmful-and-helpful antiemetic decision, and the dangerous non-gastrointestinal mimics of DKA, sepsis and brain tumour.

high14 referencesUpdated 15 July 202618 min readVerification in progress

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Target exams

RACP DWERACP DCEMRCPCH TheoryMRCPCH ClinicalABP General PediatricsRCPSC Pediatrics

Red flags

  • Bilious (green) vomiting at any age is malrotation with midgut volvulus until proven otherwise and demands urgent surgical review
  • Abdominal distension, tenderness, guarding or an absence of bowel sounds signalling obstruction or peritonitis
  • Blood in the vomit or a redcurrant-jelly stool pointing to intussusception or significant gastrointestinal bleeding
  • A bulging fontanelle, early-morning vomiting, headache, abnormal eye movements or focal neurology suggesting raised intracranial pressure
  • Altered conscious state, deep sighing (Kussmaul) breathing, or dehydration out of proportion to the history suggesting diabetic ketoacidosis or a metabolic crisis
  • A shocked, mottled or lethargic infant in whom sepsis, a surgical abdomen or an inborn error of metabolism must be excluded
  • Projectile non-bilious vomiting with visible peristalsis and weight loss in a 2 to 8 week old infant suggesting pyloric stenosis

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

community-schooloutpatientwarded-acutepicuretrievalrural-remotetelehealth

Clinical exam formats

written-only

Board mappings

  • Takes a structured vomiting history including the colour of the vomit and feeding pattern
  • Recognises bilious vomiting as a surgical emergency at any age
  • Assesses hydration and initiates oral or intravenous rehydration
  • Builds an age-based differential and separates surgical from medical causes
  • Justifies the selective use of ondansetron and the avoidance of routine antiemetics
  • Recognises the dangerous non-gastrointestinal mimics of DKA, sepsis and raised intracranial pressure
  • Emergency recognition and stabilisation of the bilious-vomiting infant
  • Risk-stratified management of the dehydrated child with gastroenteritis
  • Diagnosis of pyloric stenosis and its metabolic derangement
  • Bedside assessment of hydration and the vomiting child
  • Communication of the oral rehydration plan and safety-net to a family
  • Explaining the need for urgent surgery to the parents of an infant with volvulus
  • Level 1: Recognises bilious vomiting and dehydration as red flags
  • Level 2: Diagnosis and initial management of the common causes of vomiting
  • Level 3: Management of the shocked or surgical vomiting child and the dangerous mimics
  • The vomiting reflex and its four afferent inputs
  • The age-based differential diagnosis of vomiting
  • The metabolic derangement of pyloric stenosis and the fluid management of DKA
  • History and examination of the vomiting child
  • Structured assessment of dehydration using a validated scale
  • Communication of a rehydration and safety-net plan
  • Diagnosis of the surgical causes of vomiting by age
  • Oral rehydration therapy and the evidence for ondansetron
  • Recognition of DKA and raised intracranial pressure in the vomiting child
  • Emergency recognition of the surgical and metabolic vomiting child
  • Risk-stratified outpatient versus inpatient management of gastroenteritis
  • Fluid and electrolyte management of the dehydrated child
  • Bilious vomiting and malrotation in the Canadian paediatric setting
  • Clinical dehydration assessment and oral rehydration
  • The dangerous non-gastrointestinal causes of paediatric vomiting
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Practise this topic

  • Short-answer question1
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Target exams

RACP DWERACP DCEMRCPCH TheoryMRCPCH ClinicalABP General PediatricsRCPSC Pediatrics

Red flags

  • Bilious (green) vomiting at any age is malrotation with midgut volvulus until proven otherwise and demands urgent surgical review
  • Abdominal distension, tenderness, guarding or an absence of bowel sounds signalling obstruction or peritonitis
  • Blood in the vomit or a redcurrant-jelly stool pointing to intussusception or significant gastrointestinal bleeding
  • A bulging fontanelle, early-morning vomiting, headache, abnormal eye movements or focal neurology suggesting raised intracranial pressure
  • Altered conscious state, deep sighing (Kussmaul) breathing, or dehydration out of proportion to the history suggesting diabetic ketoacidosis or a metabolic crisis
  • A shocked, mottled or lethargic infant in whom sepsis, a surgical abdomen or an inborn error of metabolism must be excluded
  • Projectile non-bilious vomiting with visible peristalsis and weight loss in a 2 to 8 week old infant suggesting pyloric stenosis

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

community-schooloutpatientwarded-acutepicuretrievalrural-remotetelehealth

Clinical exam formats

written-only

Board mappings

  • Takes a structured vomiting history including the colour of the vomit and feeding pattern
  • Recognises bilious vomiting as a surgical emergency at any age
  • Assesses hydration and initiates oral or intravenous rehydration
  • Builds an age-based differential and separates surgical from medical causes
  • Justifies the selective use of ondansetron and the avoidance of routine antiemetics
  • Recognises the dangerous non-gastrointestinal mimics of DKA, sepsis and raised intracranial pressure
  • Emergency recognition and stabilisation of the bilious-vomiting infant
  • Risk-stratified management of the dehydrated child with gastroenteritis
  • Diagnosis of pyloric stenosis and its metabolic derangement
  • Bedside assessment of hydration and the vomiting child
  • Communication of the oral rehydration plan and safety-net to a family
  • Explaining the need for urgent surgery to the parents of an infant with volvulus
  • Level 1: Recognises bilious vomiting and dehydration as red flags
  • Level 2: Diagnosis and initial management of the common causes of vomiting
  • Level 3: Management of the shocked or surgical vomiting child and the dangerous mimics
  • The vomiting reflex and its four afferent inputs
  • The age-based differential diagnosis of vomiting
  • The metabolic derangement of pyloric stenosis and the fluid management of DKA
  • History and examination of the vomiting child
  • Structured assessment of dehydration using a validated scale
  • Communication of a rehydration and safety-net plan
  • Diagnosis of the surgical causes of vomiting by age
  • Oral rehydration therapy and the evidence for ondansetron
  • Recognition of DKA and raised intracranial pressure in the vomiting child
  • Emergency recognition of the surgical and metabolic vomiting child
  • Risk-stratified outpatient versus inpatient management of gastroenteritis
  • Fluid and electrolyte management of the dehydrated child
  • Bilious vomiting and malrotation in the Canadian paediatric setting
  • Clinical dehydration assessment and oral rehydration
  • The dangerous non-gastrointestinal causes of paediatric vomiting

Overview & Definition

A green vomit in a newborn and a well toddler who vomits once after a viral tummy bug sit at opposite ends of the same complaint, and the whole art of managing the vomiting child is telling them apart quickly. Vomiting is the forceful, coordinated retrograde expulsion of gastric contents, driven by a brainstem reflex, and it must be separated from the effortless posseting and regurgitation of a thriving infant, which needs reassurance rather than investigation.[3]

Most acute vomiting in children is benign and self-limiting, usually viral gastroenteritis, and the task is to keep the child hydrated and safe at home.[2] The clinical danger is that the same symptom is the presenting sign of a short list of time-critical conditions: a twisting midgut, a telescoping bowel, a decompensating diabetic, an obstructing pylorus, an overwhelming sepsis, and a rising intracranial pressure. The examiner wants to see that you can hold the common and the catastrophic in mind at once.[10]

One-line answer for the exam

Treat every child who vomits as gastroenteritis only after you have actively excluded the surgical and metabolic emergencies: bilious vomiting is a volvulus until proven otherwise, and vomiting with drowsiness, distension, blood, or dehydration out of proportion demands a cause beyond the gut.[10]

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References14ShowHide
  1. [1]Freedman SB, Adler M, Seshadri R, et al. Oral ondansetron for gastroenteritis in a pediatric emergency department. N Engl J Med, 2006.PMID 16625009
  2. [2]Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr, 2014.PMID 24739189
  3. [3]Khanna R, Lakhanpaul M, Burman-Roy S, et al. Diarrhoea and vomiting caused by gastroenteritis in children under 5 years: summary of NICE guidance. BMJ, 2009.PMID 19386673
  4. [4]Friedman JN, Goldman RD, Srivastava R, et al. Development of a clinical dehydration scale for use in children between 1 and 36 months of age. J Pediatr, 2004.PMID 15289767
  5. [5]Goldman RD, Friedman JN, Parkin PC Validation of the clinical dehydration scale for children with acute gastroenteritis. Pediatrics, 2008.PMID 18762524
  6. [6]Vinycomb TI, Laslett K, Gwini SM, et al. Presentation and outcomes in hypertrophic pyloric stenosis: An 11-year review. J Paediatr Child Health, 2019.PMID 30677197
  7. [7]Staerkle RF, Lunger F, Fink L, et al. Open versus laparoscopic pyloromyotomy for pyloric stenosis. Cochrane Database Syst Rev, 2021.PMID 33686649
  8. [8]del-Pozo G, Albillos JC, Tejedor D, et al. Intussusception in children: current concepts in diagnosis and enema reduction. Radiographics, 1999.PMID 10194781
  9. [9]Liu L, Zhang L, Fang Y, et al. Air enema reduction versus hydrostatic enema reduction for intussusceptions in children: A systematic review and meta-analysis. PLoS One, 2024.PMID 38498581
  10. [10]Filion L, Beaunoyer M, Miron MC, et al. Infant malrotation with midgut volvulus: A retrospective review of clinical presentation and delays in care at a Canadian tertiary paediatric centre. Paediatr Child Health, 2025.PMID 41049711
  11. [11]Li BUK Managing cyclic vomiting syndrome in children: beyond the guidelines. Eur J Pediatr, 2018.PMID 30076469
  12. [12]Wolfsdorf JI, Glaser N, Agus M, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatr Diabetes, 2018.PMID 29900641
  13. [13]Shanmugavadivel D, Liu JF, Murphy L, et al. Accelerating diagnosis for childhood brain tumours: an analysis of the HeadSmart UK population data. Arch Dis Child, 2020.PMID 31653616
  14. [14]Freedman SB, Williamson-Urquhart S, Farion KJ, et al. Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis. N Engl J Med, 2018.PMID 30462939

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