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Paeds Topicsclinical-assessment-and-reasoning

Paeds · clinical-assessment-and-reasoning

Medication reconciliation and polypharmacy in children

Also known as Medicines reconciliation in children · Paediatric medication reconciliation · Polypharmacy in children · Best Possible Medication History · Paediatric deprescribing

A fellowship approach to paediatric medication reconciliation and polypharmacy: Best Possible Medication History, intentional versus unintentional discrepancies, high-risk transitions, children with medical complexity, liquid dosing safety, deprescribing and teach-back communication across ANZ, UK, US and Canada.

medium36 referencesUpdated 11 July 202615 min readVerification in progress

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Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Unintentional omission of critical chronic therapy (anticonvulsant, steroid, insulin, immunosuppressant)
  • Unknown home regimen in a technology-dependent or critically ill child
  • Therapeutic duplication of high-alert or sedating medicines
  • Liquid concentration unknown with volume-only dosing
  • Temporary inpatient medicines left on the discharge list
  • Caregiver cannot demonstrate the correct dose after counselling
  • Language discordance without professional interpreter for medication teaching

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutenicupicuretrievalrural-remotetelehealth

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-history-managementmrcpch-communicationmrcpch-videorcpsc-structured-oral

Board mappings

  • General and Community Paediatrics
  • Clinical Pharmacology and Therapeutics
  • Current 2026 PREP curriculum — Learning Objective 1.2.2: Communicate with parents or carers
  • Current 2026 PREP curriculum — Learning Objective 2.2.1: Recognise, prioritise and manage an acutely ill infant, child or young person
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 5: Clinical assessment – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 6: Clinical management – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 12: Communication with patients, families, and health professionals
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 14: Regional, rural, and remote paediatric care
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 15: Essential general paediatrics
  • Clinical Applications
  • Patient safety and quality
  • Long Cases
  • Short Cases
  • 4. Professional skills and knowledge: Patient management
  • 7. Patient safety, including safe prescribing
  • 2. Professional skills and knowledge: Communication
  • 6. Leadership and team working
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • History
  • Communication
  • Clinical
  • General Pediatrics Content Outline — Domain 24: Patient Safety, Quality Improvement, and Research Methods
  • General Pediatrics Content Outline — Domain 1: Preventive Pediatrics/Well-Child Care
  • General Pediatrics EPA 8: Executing Clinical Handovers Within or Across Settings
  • General Pediatrics EPA 10: Leading Interprofessional Teams to Provide Collaborative, Family-Centered Care
  • Patient Care 5: Patient Management
  • Systems-Based Practice 1: Patient Safety and Quality Improvement
  • Systems-Based Practice 3: System Navigation for Patient Centered Care – Coordination of Care
  • Systems-Based Practice 4: System Navigation for Patient-Centered Care – Transitions in Care
  • Interpersonal and Communication Skills 1: Patient- and Family-Centered Communication
  • Interpersonal and Communication Skills 2: Interprofessional and Team Communication
  • Medical Expert
  • Collaborator
  • Leader
  • Communicator
  • Pediatrics: Foundations EPA #10 — Transferring clinical information between health care providers during handover
  • Pediatrics: Core EPA #11 — Coordinating transitions of care for patients with medical or psychosocial complexity
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Practise this topic

  • Short-answer question1
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Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Unintentional omission of critical chronic therapy (anticonvulsant, steroid, insulin, immunosuppressant)
  • Unknown home regimen in a technology-dependent or critically ill child
  • Therapeutic duplication of high-alert or sedating medicines
  • Liquid concentration unknown with volume-only dosing
  • Temporary inpatient medicines left on the discharge list
  • Caregiver cannot demonstrate the correct dose after counselling
  • Language discordance without professional interpreter for medication teaching

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutenicupicuretrievalrural-remotetelehealth

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-history-managementmrcpch-communicationmrcpch-videorcpsc-structured-oral

Board mappings

  • General and Community Paediatrics
  • Clinical Pharmacology and Therapeutics
  • Current 2026 PREP curriculum — Learning Objective 1.2.2: Communicate with parents or carers
  • Current 2026 PREP curriculum — Learning Objective 2.2.1: Recognise, prioritise and manage an acutely ill infant, child or young person
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 5: Clinical assessment – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 6: Clinical management – essential general paediatrics
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 12: Communication with patients, families, and health professionals
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 14: Regional, rural, and remote paediatric care
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 15: Essential general paediatrics
  • Clinical Applications
  • Patient safety and quality
  • Long Cases
  • Short Cases
  • 4. Professional skills and knowledge: Patient management
  • 7. Patient safety, including safe prescribing
  • 2. Professional skills and knowledge: Communication
  • 6. Leadership and team working
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • History
  • Communication
  • Clinical
  • General Pediatrics Content Outline — Domain 24: Patient Safety, Quality Improvement, and Research Methods
  • General Pediatrics Content Outline — Domain 1: Preventive Pediatrics/Well-Child Care
  • General Pediatrics EPA 8: Executing Clinical Handovers Within or Across Settings
  • General Pediatrics EPA 10: Leading Interprofessional Teams to Provide Collaborative, Family-Centered Care
  • Patient Care 5: Patient Management
  • Systems-Based Practice 1: Patient Safety and Quality Improvement
  • Systems-Based Practice 3: System Navigation for Patient Centered Care – Coordination of Care
  • Systems-Based Practice 4: System Navigation for Patient-Centered Care – Transitions in Care
  • Interpersonal and Communication Skills 1: Patient- and Family-Centered Communication
  • Interpersonal and Communication Skills 2: Interprofessional and Team Communication
  • Medical Expert
  • Collaborator
  • Leader
  • Communicator
  • Pediatrics: Foundations EPA #10 — Transferring clinical information between health care providers during handover
  • Pediatrics: Core EPA #11 — Coordinating transitions of care for patients with medical or psychosocial complexity
The fellowship answer

Medication reconciliation is a verified process that builds one accurate list, finds the gaps, fixes the important ones, and teaches the family—not a checkbox beside an old discharge summary. In children, polypharmacy is less about a magic number of tablets and more about many active medicines, complex schedules, liquid forms and multiple prescribers. If the child is unstable from drug harm or disease, treat life threats first. Then build a Best Possible Medication History, classify intentional versus unintentional discrepancies, prioritise critical omissions and high-alert errors, simplify when safe, and close the loop to the medical home. [1] [6] [23]

Overview & Definition

Picture a seven-year-old with epilepsy arriving in ED after a seizure. The electronic list shows “levetiracetam.” Mother says the dose changed last week. A second bottle of clobazam is in the bag but missing from the chart. The last discharge summary still lists a temporary lorazepam PRN from a prior admission. If you prescribe from the screen alone, you are guessing. That guess is how children are harmed. [13] [17] [1]

Medication reconciliation is the structured process of obtaining the best possible list of a child’s current medicines, comparing it with what is ordered or dispensed at a transition of care, resolving differences, and communicating the final plan. It is work, not a click. [1] [23] [24]

A Best Possible Medication History (BPMH) is that verified list. You build it from more than one source: caregiver interview, medicine bottles or photos, pharmacy records, specialty letters and the electronic record. Copying the last discharge list is not a BPMH. [1] [18]

Polypharmacy in children means a child is taking multiple medicines in a way that raises complexity, interaction risk, administration burden or uncertainty about ongoing need. Adult cut-offs such as “five drugs” are a weak exam answer on their own. In children with medical complexity, many concurrent medicines are common; the clinical task is to make the regimen safer and purposeful, not to shame the count. [6] [7] [8] [27]

Why children are different

Weight-based dosing, liquid concentrations, off-label use, school-administered doses, caregiver measurement and rapid growth all create error modes that adult reconciliation checklists miss. Home administration teaching is part of reconciliation, not an optional extra. [34] [35] [7]

What reconciliation actually does

  1. 1

    Gather sources

    Interview caregivers, inspect bottles or photos, call pharmacy, read specialty notes and prior discharges.

  2. 2

    Build the BPMH

    For each medicine capture name, strength or concentration, dose, route, frequency, indication, last dose and adherence.

  3. 3

    Compare and classify

    Match the BPMH to current orders. Label each difference intentional or unintentional.

  4. 4

    Fix what matters

    Correct clinically important unintentional gaps the same shift; document intentional holds.

  5. 5

    Teach and hand off

    Use teach-back, supply the right devices, and send the final list to the medical home and family.

[1] [23] [2]
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References36ShowHide
  1. [1]Merandi J, Sapko M, Catt C, et al. Medication Reconciliation. Pediatrics in review, 2017.PMID 28044039
  2. [2]Sheth S, Bialostozky M, Hollenbach K, et al. Standardizing Medication Reconciliation in a Pediatric Emergency Department. Pediatrics, 2024.PMID 38273780
  3. [3]Condren M, Bowling S, Hall B, et al. Medication Reconciliation Across Care Transitions in the Pediatric Medical Home. Joint Commission journal on quality and patient safety, 2019.PMID 30898508
  4. [4]Morse KE, Chadwick WA, Paul W, et al. Quantifying Discharge Medication Reconciliation Errors at 2 Pediatric Hospitals. Pediatric quality & safety, 2021.PMID 34345749
  5. [5]Gunkelman SM, Jamerino-Thrush J, Genet K, et al. Improving Accuracy of Medication Reconciliation for Hospitalized Children: A Quality Project. Hospital pediatrics, 2024.PMID 38529561
  6. [6]Feinstein JA, Orth LE Making Polypharmacy Safer for Children with Medical Complexity. The Journal of pediatrics, 2023.PMID 36252865
  7. [7]Huth K, Vandecruys P, Orkin J, et al. Medication safety for children with medical complexity. Paediatrics & child health, 2020.PMID 33178368
  8. [8]Zanin A, Baratiri F, Roverato B, et al. Polypharmacy in Children with Medical Complexity: A Cross-Sectional Study in a Pediatric Palliative Care Center. Children (Basel, Switzerland), 2024.PMID 39062270
  9. [9]Alqenae FA, Steinke D, Keers RN Prevalence and Nature of Medication Errors and Medication-Related Harm Following Discharge from Hospital to Community Settings: A Systematic Review. Drug safety, 2020.PMID 32125666
  10. [10]Aires-Moreno GT, Alcântara TDS, Araújo DCSA, et al. Medication discrepancies in transition of care of hospitalised children in Brazil: a multicentric study. Archives of disease in childhood, 2021.PMID 33958348
  11. [11]Starmer AJ, Spector ND, Srivastava R, et al. Changes in medical errors after implementation of a handoff program. The New England journal of medicine, 2014.PMID 25372088
  12. [12]Gattari TB, Krieger LN, Hu HM, et al. Medication Discrepancies at Pediatric Hospital Discharge. Hospital pediatrics, 2015.PMID 26231634
  13. [13]Louiselle K, Harte L, Thompson C, et al. Medication Discrepancy Risk Factors for Pediatric Patients With Epilepsy at Hospital Admission. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2021.PMID 34035684
  14. [14]Moss JG, Young D, Rashed AN, et al. Paediatric polypharmacy and deprescribing: the views of UK healthcare professionals. Archives of disease in childhood, 2023.PMID 35701176
  15. [15]Zito JM, Zhu Y, Safer DJ Psychotropic Polypharmacy in the US Pediatric Population: A Methodologic Critique and Commentary. Frontiers in psychiatry, 2021.PMID 34194346
  16. [16]DeCourcey DD, Silverman M, Chang E, et al. Medication Reconciliation Failures in Children and Young Adults With Chronic Disease During Intensive and Intermediate Care. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017.PMID 28198758
  17. [17]Huynh C, Tomlin S, Jani Y, et al. An evaluation of the epidemiology of medication discrepancies and clinical significance of medicines reconciliation in children admitted to hospital. Archives of disease in childhood, 2016.PMID 26566687
  18. [18]Huynh C, Wong IC, Tomlin S, et al. Medication discrepancies at transitions in pediatrics: a review of the literature. Paediatric drugs, 2013.PMID 23670796
  19. [19]Huynh C, Wong IC, Tomlin S, et al. An evaluation of paediatric medicines reconciliation at hospital discharge into the community. The International journal of pharmacy practice, 2016.PMID 26670624
  20. [20]Wong JD, Bajcar JM, Wong GG, et al. Medication reconciliation at hospital discharge: evaluating discrepancies. The Annals of pharmacotherapy, 2008.PMID 18780806
  21. [21]Cornish PL, Knowles SR, Marchesano R, et al. Unintended medication discrepancies at the time of hospital admission. Archives of internal medicine, 2005.PMID 15738372
  22. [22]Tam VC, Knowles SR, Cornish PL, et al. Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2005.PMID 16129874
  23. [23]Kwan JL, Lo L, Sampson M, et al. Medication reconciliation during transitions of care as a patient safety strategy: a systematic review. Annals of internal medicine, 2013.PMID 23460096
  24. [24]Mueller SK, Sponsler KC, Kripalani S, et al. Hospital-based medication reconciliation practices: a systematic review. Archives of internal medicine, 2012.PMID 22733210
  25. [25]Coffey M, Mack L, Streitenberger K, et al. Prevalence and clinical significance of medication discrepancies at pediatric hospital admission. Academic pediatrics, 2009.PMID 19640822
  26. [26]Kulawiak J, Jacobson JL, Miller JA, et al. Evaluation of a Pharmacist-Driven Discharge Medication Reconciliation Service Pilot at a Children's Hospital. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2024.PMID 39411418
  27. [27]Grossberg R Polypharmacy-An Important Contributor to Health and Safety for Children With Medical Complexity: How Can We Improve Care for This Vulnerable Population? The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2024.PMID 38596412
  28. [28]Reedy J, Thompson T, Begum A, et al. Challenges of managing pediatric polypharmacy in a pediatric complex care program: A qualitative pilot study. Journal of the American Pharmacists Association : JAPhA, 2025.PMID 40127839
  29. [29]Alcântara TDS, de Araújo Neto FC, Lima HF, et al. Prevalence of medication discrepancies in pediatric patients transferred between hospital wards. International journal of clinical pharmacy, 2021.PMID 33175294
  30. [30]Kuo DZ, Houtrow AJ Recognition and Management of Medical Complexity. Pediatrics, 2016.PMID 27940731
  31. [31]Kuo DZ, McAllister JW, Rossignol L, et al. Care Coordination for Children With Medical Complexity: Whose Care Is It, Anyway? Pediatrics, 2018.PMID 29496973
  32. [32]Zennaro M, Trotter A, Mengato D, et al. Improving Medication Safety Through Medication Reconciliation in Pediatric Neurology: Clinical Pharmacist Recommendations and Physician Uptake in a 13-Week Study. Children (Basel, Switzerland), 2025.PMID 40426804
  33. [33]Adducchio S, Grant ED, Fonseca LD, et al. Reducing Discharge Medication Reconciliation Errors at a Pediatric Neurology Inpatient Unit. Neurology. Clinical practice, 2024.PMID 38524835
  34. [34]Yin HS, Neuspiel DR, Paul IM, et al. Preventing Home Medication Administration Errors. Pediatrics, 2021.PMID 34851406
  35. [35]Yin HS, Parker RM, Sanders LM, et al. Pictograms, Units and Dosing Tools, and Parent Medication Errors: A Randomized Study. Pediatrics, 2017.PMID 28759396
  36. [36]Yin HS, Parker RM, Sanders LM, et al. Effect of Medication Label Units of Measure on Parent Choice of Dosing Tool: A Randomized Experiment. Academic pediatrics, 2016.PMID 27155289

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