Paeds · cardiology
Heart failure in infants and children
Also known as Heart failure in infants and children · Paediatric heart failure · Congestive heart failure in children · Infant heart failure · Cardiomyopathy with heart failure
Fellowship guide to heart failure as a clinical syndrome in infants and children: the volume-overload, pressure-overload and pump-failure mechanisms, the modified Ross severity grading, the neurohormonal vicious cycle, the infant presentation of tachypnoea and failure to thrive, echocardiographic assessment, acute resuscitation and chronic neurohormonal therapy, the carvedilol evidence, and escalation to the Berlin Heart EXCOR ventricular assist device and transplantation.
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Overview & Definition
Heart failure in a child is a clinical syndrome in which the heart cannot deliver enough blood to meet the body's metabolic demands, or can do so only at abnormally high filling pressures. It is not a single diagnosis: it is the end result of many different problems, and the whole skill of paediatric heart failure lies in finding the mechanism that is failing. [3]
Because cardiac output is the product of stroke volume and heart rate, anything that reduces stroke volume — a failing pump, a volume load that dilates the ventricle, or a pressure load that stiffens it — produces the same syndrome of poor perfusion and congestion. In adults heart failure is usually the consequence of coronary disease and a stiff, aging myocardium; in children it is usually the consequence of a structural congenital lesion or an intrinsic cardiomyopathy, which is why so much of childhood heart failure is surgically curable once the cause is found. [3] [4]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship atlas.
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- [1]Hoffman JI; Kaplan S The incidence of congenital heart disease. J Am Coll Cardiol, 2002.PMID 12084585
- [2]van der Linde D; Konings EE; Slager MA; Witsenburg M; Helbing WA; Takkenberg JJ; Roos-Hesselink JW Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol, 2011.PMID 22078432
- [3]Hsu DT; Pearson GD Heart failure in children: part I: history, etiology, and pathophysiology. Circ Heart Fail, 2009.PMID 19808316
- [4]Hsu DT; Pearson GD Heart failure in children: part II: diagnosis, treatment, and future directions. Circ Heart Fail, 2009.PMID 19808380
- [5]Ross RD The Ross classification for heart failure in children after 25 years: a review and an age-stratified revision. Pediatr Cardiol, 2012.PMID 22476605
- [6]Kantor PF; Lougheed J; Dancea A; McGillion M; Barbosa N; Chan W; Cherney DZ; Gandhi S; Holtby HM; Human DG; McCrindle BW; Prieur T; Conway J; Canadian Cardiovascular Society Presentation, diagnosis, and medical management of heart failure in children: Canadian Cardiovascular Society guidelines. Can J Cardiol, 2013.PMID 24267800
- [7]Shaddy RE; Boucek MM; Hsu DT; Boucek RJ; Sanders SP; Mineral S; Pahl E; Miyamoto SD; Tresed M; Pediatic Carvedilol Study Group Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA, 2007.PMID 17848651
- [8]Rossano JW; Kantor PF; Shaddy RE; Shi L; Lipshultz SE; Colan SD; Sleeper LA; Towbin JA; Jefferies JL; Everitt MD; Hsu DT; Wilkinson JD; Pediatric Cardiomyopathy Registry Elevated heart rate and survival in children with dilated cardiomyopathy: a multicenter study from the Pediatric Cardiomyopathy Registry. J Am Heart Assoc, 2020.PMID 32750307
- [9]Kantor PF; Shi L; Colan SD; Orav EJ; Mayer JE; Sleeper LA; Lipshultz SE; Pediatric Cardiomyopathy Registry Progressive left ventricular remodeling for predicting mortality in children with dilated cardiomyopathy: the Pediatric Cardiomyopathy Registry. J Am Heart Assoc, 2024.PMID 38214257
- [10]Almond CS; Morales DL; Blackstone EH; Turrentine MW; Imamura M; Massicotte MP; Jordan LC; Meyer DM; Das NA; Lorts A; Morales RS; Davies RR; Nikaidoh H; Muenzer JR; Rosenthal DN; Morell VO; Kanter KR; Mahle WT; Fraser CD Jr Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children. Circulation, 2013.PMID 23538380
- [11]Baumgartner H; De Backer J; Babu-Narayan SV; Budts W; Chessa M; Diller GP; Lung B; Kluin J; Lang IM; Meijboom F; Moons P; Mulder BJM; Oechslin E; Roos-Hesselink JW; Schwerzmann M; Sullebarger L; Van Hare GF; ESC Scientific Document Group 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J, 2020.PMID 33128054
- [12]Wilson WR; Gewitz M; Lockhart PB; Bolger AF; DeSimone DC; Koenig MJ; Sadhu Lohr J; Miro JM; Padera RF; Prendergast BD; Sexton DJ; Spelman DW; Tleyjeh IM; Van der Meer JTM; Westermann CJL; Whited W; Wojda TR; American Heart Association Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association. Circulation, 2021.PMID 33853363