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Paeds Topicsallergy-and-immunology

Paeds · allergy-and-immunology

Atopic dermatitis and the atopic march

Also known as atopic eczema · atopic dermatitis · childhood eczema · infantile eczema · the atopic march · atopic march

A chronic, itchy, relapsing inflammatory skin disease of childhood driven by epidermal barrier failure and Th2-skewed immunity, presenting with age-pattern eczema; managed with a stepwise emollient-and-topical-steroid ladder and linked to the atopic march of food allergy, asthma and rhinitis.

high14 referencesUpdated 12 July 202618 min readVerification in progress

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Target exams

RACP DWEMRCPCH TheoryABP General Pediatrics

Red flags

  • rapidly worsening painful eczema with monomorphic punched-out vesicles suggesting eczema herpeticum
  • fever, malaise and systemic upset over an eczematous child
  • clusters of umbilicated haemorrhagic vesicles or pustules
  • failure to thrive or developmental delay pointing to an immunodeficiency syndrome
  • eczema onset in the neonatal period with severe, refractory disease suggesting a primary immunodeficiency
  • asymmetric, well-demarcated, scaly plaques suggesting tinea rather than eczema

Life stages

infanttoddlerpreschoolschool-ageadolescent

Care settings

outpatientcommunity-schoolpreventive-medical-homeed-acutetelehealth

Clinical exam formats

written-only

Board mappings

  • recognise and manage atopic dermatitis in children
  • explain the atopic march and its implications
  • apply stepwise management and escalate to systemic therapy
  • interpret severity scoring and comorbidity risk
  • high-yield: diagnostic criteria, barrier pathophysiology, stepwise ladder, eczema herpeticum
  • short-case assessment of a child with chronic eczema
  • atopic dermatitis — diagnosis, severity assessment and stepwise management
  • UK diagnostic criteria, filaggrin and barrier pathophysiology, topical therapy ladder, atopic march
  • assess and counsel the parents of a child with eczema
  • atopic dermatitis — diagnosis and stepwise management
  • atopic dermatitis — milestone: applies diagnostic criteria, initiates stepwise topical therapy, recognises complications
  • atopic dermatitis — recognise, assess severity and manage
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Saved on this device.

Practise this topic

  • Short-answer question1
  • Viva station1
  • Clinical case1

Target exams

RACP DWEMRCPCH TheoryABP General Pediatrics

Red flags

  • rapidly worsening painful eczema with monomorphic punched-out vesicles suggesting eczema herpeticum
  • fever, malaise and systemic upset over an eczematous child
  • clusters of umbilicated haemorrhagic vesicles or pustules
  • failure to thrive or developmental delay pointing to an immunodeficiency syndrome
  • eczema onset in the neonatal period with severe, refractory disease suggesting a primary immunodeficiency
  • asymmetric, well-demarcated, scaly plaques suggesting tinea rather than eczema

Life stages

infanttoddlerpreschoolschool-ageadolescent

Care settings

outpatientcommunity-schoolpreventive-medical-homeed-acutetelehealth

Clinical exam formats

written-only

Board mappings

  • recognise and manage atopic dermatitis in children
  • explain the atopic march and its implications
  • apply stepwise management and escalate to systemic therapy
  • interpret severity scoring and comorbidity risk
  • high-yield: diagnostic criteria, barrier pathophysiology, stepwise ladder, eczema herpeticum
  • short-case assessment of a child with chronic eczema
  • atopic dermatitis — diagnosis, severity assessment and stepwise management
  • UK diagnostic criteria, filaggrin and barrier pathophysiology, topical therapy ladder, atopic march
  • assess and counsel the parents of a child with eczema
  • atopic dermatitis — diagnosis and stepwise management
  • atopic dermatitis — milestone: applies diagnostic criteria, initiates stepwise topical therapy, recognises complications
  • atopic dermatitis — recognise, assess severity and manage

Overview & Definition

A baby who sleeps badly, scratches until the cheeks weep, and develops crusted red plaques on the extensor surfaces of the arms is the everyday face of atopic dermatitis in primary care. The disease is a chronic, intensely itchy, relapsing inflammatory skin disorder that begins in infancy in most children and follows a fluctuating course of flares and remissions, driven by a defective epidermal barrier and a Th2-skewed immune response. [1]

Atopic dermatitis is the most common chronic skin disease of childhood, affecting up to one in five children worldwide, and it is the first and most frequent manifestation of atopy. The term atopic march describes the typical temporal progression from atopic dermatitis and food allergy in infancy to allergic rhinitis and asthma through the preschool and school-age years, reflecting how a single barrier-and-immune defect can seed disease across multiple organ systems. [2]

What is atopic dermatitis in one sentence?A chronic, intensely pruritic, relapsing inflammatory skin disease of childhood caused by epidermal barrier failure and Th2-skewed immunity, presenting with age-typical eczematous plaques, managed with a stepwise emollient-and-topical-steroid ladder, and the usual first step of the atopic march toward food allergy, rhinitis and asthma. [1]
Eczema herpeticum is the emergencyA child with atopic dermatitis who develops rapidly worsening, painful, clustered vesicles or punched-out erosions with fever and malaise has eczema herpeticum — disseminated herpes simplex — and needs same-day systemic aciclovir and admission because secondary staphylococcal sepsis and dehydration can be life-threatening. [1]
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References14ShowHide
  1. [1]Williams HC Clinical practice. Atopic dermatitis. N Engl J Med, 2005.PMID 15930422
  2. [2]Paller AS, Spergel JM, Mina-Osorio P The atopic march and atopic multimorbidity: Many trajectories, many pathways. J Allergy Clin Immunol, 2019.PMID 30458183
  3. [3]Palmer CN, Irvine AD, Terron-Kwiatkowski A Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet, 2006.PMID 16550169
  4. [4]Simpson EL, Chalmers JR, Hanifin JM Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol, 2014.PMID 25282563
  5. [5]Bradshaw LE, Wyatt LA, Brown SJ Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT. Health Technol Assess, 2024.PMID 39021147
  6. [6]Sidbury R, Alikhan A, Bercovitch L Executive summary: American Academy of Dermatology guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol, 2023.PMID 36623556
  7. [7]Davis DMR, Drucker AM, Alikhan A American Academy of Dermatology Guidelines: Awareness of comorbidities associated with atopic dermatitis in adults. J Am Acad Dermatol, 2022.PMID 35085682
  8. [8]Du Toit G, Roberts G, Sayre PH Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med, 2015.PMID 25705822
  9. [9]Salek MS, Jung S, Brincat-Ruffini LA Clinical experience and psychometric properties of the Children's Dermatology Life Quality Index (CDLQI), 1995-2012. Br J Dermatol, 2013.PMID 23679682
  10. [10]Wollenberg A, Oranje A, Deleuran M ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol, 2016.PMID 27004560
  11. [11]van Oosterhout M, Janmohamed SR, Spierings M Correlation between Objective SCORAD and Three-Item Severity Score used by physicians and Objective PO-SCORAD used by parents/patients in children with atopic dermatitis. Dermatology, 2015.PMID 25660989
  12. [12]Paller AS, Silverberg JI, Cork MJ Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis: A Post Hoc Analysis of 6 Randomized Clinical Trials. JAMA Dermatol, 2023.PMID 36723913
  13. [13]Maintz L, Bieber T, Simpson HD From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine. J Pers Med, 2022.PMID 35743678
  14. [14]Sasaki M, Sundberg M, Frei R Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis. Allergy, 2024.PMID 37753955

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