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Paeds Topicsacute-care-resuscitation-and-toxicology

Paeds · acute-care-resuscitation-and-toxicology

Poisoned child: structured assessment and decontamination

Also known as Paediatric poisoning assessment · Toxidromes in children · Activated charcoal in paediatric overdose · Gastrointestinal decontamination in children · Poisons Information Centre consultation

A fellowship approach to the poisoned child. Resuscitate with ABCDE and treat life-threatening toxin effects first, then take a structured ingestion history, recognise the toxidrome from vital signs, pupils and mental state, and call the Poisons Information Centre early. Give activated charcoal 1 g/kg within the first hour only when the airway is safe and the toxin is adsorbable; reserve whole bowel irrigation for iron, lithium, sustained-release and packet ingestions, and enhanced elimination for the few toxins it helps. Most children need observation and supportive care, and safeguarding runs in parallel for intentional and non-accidental exposure.

high12 referencesUpdated 17 July 202618 min readVerification in progress

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Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Resuscitate first: a poisoned child with airway, breathing or circulation failure needs ABCDE stabilisation before any decontamination or antidote work-up
  • A child with a falling conscious level, pin-point pupils and slow shallow breathing has an opioid toxidrome — give naloxone and support the airway
  • Hyperthermia with rigidity, clonus or seizures suggests serotonin syndrome, neuroleptic malignant syndrome or sympathomimetic toxicity and is life-threatening
  • Wide QRS or long QT on the ECG points to cardiotoxic drug poisoning (tricyclics, sodium-channel blockers) and needs early sodium bicarbonate and critical care
  • Activated charcoal is not given when the airway is unprotected, after corrosive or hydrocarbon ingestion, or for iron, lithium, metals or toxic alcohols
  • Intentional self-harm and non-accidental poisoning must be considered in every child — safeguarding runs in parallel with medical care
  • Call the Poisons Information Centre early (Australia 13 11 26; UK NPIS; Ireland NPIC); the advice changes the decontamination and antidote plan

Life stages

infanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

ed-acutewardpicuretrievalrural-remote

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-short-clinicalmrcpch-history-managementmrcpch-communicationmrcpch-videorcpsc-structured-oral

Board mappings

  • Acute Care
  • Current 2026 PREP curriculum — Learning Objective 2.2.1: Recognise, prioritise and manage an acutely ill infant, child or young person
  • Current 2026 PREP curriculum — Learning Objective 2.2.3: Perform acute resuscitation and advanced life support
  • Current 2026 PREP curriculum — Learning Objective 2.4.4: Assess and manage infants, children and young people with potential cardiac, respiratory or neurological emergencies or acute sepsis
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 11: Acute care and procedures
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 17: Acute care
  • Clinical Applications
  • Medical Sciences
  • Long Cases
  • Short Cases
  • 4. Professional skills and knowledge: Patient management
  • 7. Patient safety, including safe prescribing
  • 10. Complex child and young person and children with medical complexity
  • General Paediatrics: Resuscitates, stabilises and treats extremely unwell babies, children and young people, liaising with specialist teams, as necessary
  • Pharmacology: Manages poisoning and intoxication and seeks appropriate specialist advice
  • Foundation of Practice (FOP)
  • Theory and Science (TAS)
  • Applied Knowledge in Practice (AKP)
  • Clinical
  • History
  • Communication
  • Video
  • General Pediatrics Content Outline — Domain 7: Emergency and Critical Care
  • General Pediatrics Content Outline — Universal Task 3: Diagnosis
  • General Pediatrics Content Outline — Universal Task 4: Management and Treatment
  • General Pediatrics EPA 7: Recognizing a Severely Ill Patient, Providing Initial Management, and Mobilizing Resources Needed for Continued Care
  • Patient Care 3: Organize and Prioritize Patient Care
  • Patient Care 4: Clinical Reasoning
  • Patient Care 5: Patient Management
  • Systems-Based Practice 1: Patient Safety
  • Interpersonal and Communication Skills 2: Interprofessional and Team Communication
  • Medical Expert
  • Pediatrics: Foundations EPA #1 — Recognizing deteriorating and/or critically ill patients and initiating stabilization and management
  • Pediatrics: Core EPA #2 — Resuscitating and stabilizing critically ill patients
On this page
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  • Short-answer question1
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Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Resuscitate first: a poisoned child with airway, breathing or circulation failure needs ABCDE stabilisation before any decontamination or antidote work-up
  • A child with a falling conscious level, pin-point pupils and slow shallow breathing has an opioid toxidrome — give naloxone and support the airway
  • Hyperthermia with rigidity, clonus or seizures suggests serotonin syndrome, neuroleptic malignant syndrome or sympathomimetic toxicity and is life-threatening
  • Wide QRS or long QT on the ECG points to cardiotoxic drug poisoning (tricyclics, sodium-channel blockers) and needs early sodium bicarbonate and critical care
  • Activated charcoal is not given when the airway is unprotected, after corrosive or hydrocarbon ingestion, or for iron, lithium, metals or toxic alcohols
  • Intentional self-harm and non-accidental poisoning must be considered in every child — safeguarding runs in parallel with medical care
  • Call the Poisons Information Centre early (Australia 13 11 26; UK NPIS; Ireland NPIC); the advice changes the decontamination and antidote plan

Life stages

infanttoddlerpreschoolschool-ageadolescentyoung-adult-transition

Care settings

ed-acutewardpicuretrievalrural-remote

Clinical exam formats

written-onlyracp-dce-long-caseracp-dce-short-casemrcpch-short-clinicalmrcpch-history-managementmrcpch-communicationmrcpch-videorcpsc-structured-oral

Board mappings

  • Acute Care
  • Current 2026 PREP curriculum — Learning Objective 2.2.1: Recognise, prioritise and manage an acutely ill infant, child or young person
  • Current 2026 PREP curriculum — Learning Objective 2.2.3: Perform acute resuscitation and advanced life support
  • Current 2026 PREP curriculum — Learning Objective 2.4.4: Assess and manage infants, children and young people with potential cardiac, respiratory or neurological emergencies or acute sepsis
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 11: Acute care and procedures
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 17: Acute care
  • Clinical Applications
  • Medical Sciences
  • Long Cases
  • Short Cases
  • 4. Professional skills and knowledge: Patient management
  • 7. Patient safety, including safe prescribing
  • 10. Complex child and young person and children with medical complexity
  • General Paediatrics: Resuscitates, stabilises and treats extremely unwell babies, children and young people, liaising with specialist teams, as necessary
  • Pharmacology: Manages poisoning and intoxication and seeks appropriate specialist advice
  • Foundation of Practice (FOP)
  • Theory and Science (TAS)
  • Applied Knowledge in Practice (AKP)
  • Clinical
  • History
  • Communication
  • Video
  • General Pediatrics Content Outline — Domain 7: Emergency and Critical Care
  • General Pediatrics Content Outline — Universal Task 3: Diagnosis
  • General Pediatrics Content Outline — Universal Task 4: Management and Treatment
  • General Pediatrics EPA 7: Recognizing a Severely Ill Patient, Providing Initial Management, and Mobilizing Resources Needed for Continued Care
  • Patient Care 3: Organize and Prioritize Patient Care
  • Patient Care 4: Clinical Reasoning
  • Patient Care 5: Patient Management
  • Systems-Based Practice 1: Patient Safety
  • Interpersonal and Communication Skills 2: Interprofessional and Team Communication
  • Medical Expert
  • Pediatrics: Foundations EPA #1 — Recognizing deteriorating and/or critically ill patients and initiating stabilization and management
  • Pediatrics: Core EPA #2 — Resuscitating and stabilizing critically ill patients
The fellowship answer

Resuscitate first. Stabilise the airway, breathing and circulation and treat the life-threatening toxin effects (hypoglycaemia, opioid respiratory depression, wide-complex cardiotoxicity, hyperthermia) before any decontamination work-up. Then take a structured ingestion history, recognise the toxidrome from the vital signs, pupils and mental state, and call the Poisons Information Centre early. Give activated charcoal at 1 g/kg to a maximum of 50 g within the first hour only when the airway is protected and the toxin is adsorbable; reserve whole bowel irrigation for iron, lithium, sustained-release and packet ingestions, and enhanced elimination for the few toxins it helps. Most children need observation and supportive care, and safeguarding runs in parallel for intentional and non-accidental exposure. [1] [9]

Overview & Definition

A poisoned child is any infant, child or young person who has been exposed to a substance that can cause harm, whether by ingestion, inhalation, skin or eye contact, or injection. The exposure may be accidental in a curious toddler, recreational in an adolescent, intentional in self-harm, or non-accidental in an abused child. The exposure that walks through the door is usually benign, occasionally lethal, and frequently uncertain, so the discipline of the assessment is what keeps the rare dangerous case from being missed. [9] [10]

The aim of care is not to name the toxin first. It is to keep the child alive while the substance, dose and time are worked out, to remove or neutralise what can be removed, to give an antidote where one exists, and to support organ function while the toxin clears. Decontamination is a small but examined part of this, and it always follows resuscitation, never precedes it. The child who is aspirating or in shock is harmed, not helped, by a dose of charcoal. [1] [12]

Resuscitation before decontamination

Airway, breathing and circulation come first in every poisoned child. No gastrointestinal decontamination is performed until the airway is safe, oxygenation and ventilation are adequate, shock is treated, hypoglycaemia is corrected, and any immediately life-threatening toxin effect (opioid apnoea, cardiotoxic rhythm, hyperthermia) is addressed. Decontamination that destabilises a child is never the right answer.

[9] [12]
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References12ShowHide
  1. [1]Hoffman RJ, Nillas A Toxidromes and a general approach to poisoning Archives of disease in childhood, 2025.PMID 39978865
  2. [2]Hui WF, Hon KL, Leung AKC An Overview of the Pediatric Toxidromes and Poisoning Management Current reviews in clinical and experimental pharmacology, 2021.PMID 33261543
  3. [3]Hoegberg LCG, Shepherd G, Wood DM, et al. Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose Clinical toxicology (Philadelphia, Pa.), 2021.PMID 34424785
  4. [4]Hoegberg LCG, Gosselin S, Buckley NA, et al. Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose Clinical toxicology (Philadelphia, Pa.), 2026.PMID 41906697
  5. [5]Zhao X, Dughly O, Simpson J Decontamination of the pediatric patient Current opinion in pediatrics, 2016.PMID 27031659
  6. [6]Lapus RM Activated charcoal for pediatric poisonings: the universal antidote? Current opinion in pediatrics, 2007.PMID 17496769
  7. [7]Tenenbein M Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists Journal of toxicology. Clinical toxicology, 1997.PMID 9482429
  8. [8]Lo JC, Ubaldo C, Cantrell FL A retrospective review of whole bowel irrigation in pediatric patients Clinical toxicology (Philadelphia, Pa.), 2012.PMID 22578074
  9. [9]Berg SE, McCann SD Pediatric Toxicology: An Updated Review Pediatric annals, 2023.PMID 37036778
  10. [10]Ross JA, Eldridge DL Pediatric Toxicology Emergency medicine clinics of North America, 2022.PMID 35461621
  11. [11]Gummin DD, Mowry JB, Beuhler MC, et al. 2022 Annual Report of the National Poison Data System (NPDS) from America's Poison Centers: 40th Annual Report Clinical toxicology (Philadelphia, Pa.), 2023.PMID 38084513
  12. [12]Bond GR The role of activated charcoal and gastric emptying in gastrointestinal decontamination: a state-of-the-art review Annals of emergency medicine, 2002.PMID 11867980

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