Paeds Cases · allergy-and-immunology
The child with recurrent facial swelling and a family airway history — structured encounter
A structured clinical encounter testing the approach to recurrent angioedema without wheals: recognising the bradykinin pathway, using the C4 screen, confirming hereditary angioedema, explaining why antihistamines fail, and building an on-demand treatment and prophylaxis plan that protects the airway and screens the family.
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Setting and candidate instructions
You are the paediatric registrar in the outpatient clinic. A ten-year-old boy is referred by his general practitioner for three episodes of painless facial and lip swelling over the past year. Each episode lasted two to three days, occurred without any wheals or itch, and resolved spontaneously. Between attacks he is entirely well. His father, who accompanies him, describes similar episodes in his own childhood and one emergency intubation for throat swelling at the age of twenty. The boy is currently well, with no swelling, no airway symptoms and normal observations. The examiner will ask you to build the differential, choose the pivotal investigation, explain the mechanism, and construct a treatment and disposition plan that protects the airway and addresses the family. [9]
References3ShowHide
- [9]Farkas H International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema Allergy, 2026.PMID 41618059
- [10]Maurer M The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update Allergy, 2022.PMID 35006617
- [1]Zuberbier T The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria Allergy, 2022.PMID 34536239