Paeds Cases · clinical-pharmacology-and-therapeutics
Screen before you prescribe — immunosuppressive and biologic therapy
A bedside structured clinical encounter testing the safe initiation of methotrexate in juvenile idiopathic arthritis and the pre-biotic screen before a tumour necrosis factor inhibitor, including the weekly-versus-daily distinction, folic acid, full-blood-count and liver-enzyme monitoring, dual tuberculosis screening, the live-vaccine rule, and communication with the family.
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This is one MedVellum formative structured clinical encounter. The scoring, prompts and performance descriptions are educational feedback tools. They are not an official college station, timing, mark allocation, pass score or reproduced examination format. The encounter assesses the safe initiation of methotrexate in juvenile idiopathic arthritis, the pre-biologic screen before a tumour necrosis factor inhibitor, the weekly-versus-daily distinction, folic acid, monitoring, the live-vaccine rule, and family communication. [5] [9]
References5ShowHide
- [1]Giannini EH; Brewer EJ; Kuzmina N Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group The New England journal of medicine, 1992.PMID 1549149
- [5]Ferrara G; Mastrangelo G; Barone P Methotrexate in juvenile idiopathic arthritis: advice and recommendations from the MARAJIA expert consensus meeting Pediatric rheumatology online journal, 2018.PMID 29996864
- [9]Calzada-Hernández J; Anton J; Martín de Carpi J Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-α inhibitor initiation in children in Spain European journal of pediatrics, 2023.PMID 36335186
- [10]Parigi S; Licari A; Manti S Tuberculosis and TNF-α inhibitors in children: how to manage a fine balance Acta bio-medica : Atenei Parmensis, 2020.PMID 33004779
- [11]Jansen MHA; Rondaan C; Legger GE EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021 Annals of the rheumatic diseases, 2023.PMID 35725297