Paeds Cases · clinical-pharmacology-and-therapeutics
The right dose, the right cap, the right child — analgesic and antipyretic prescribing
A bedside structured clinical encounter testing the safe choice, calculation and prescription of a paediatric analgesic and antipyretic: obtaining a measured weight, scoring the pain, calculating the paracetamol and ibuprofen doses with the adult ceiling, taking a position on alternating agents, respecting the aspirin and codeine restrictions, escalating to a monitored opioid for severe pain, and closing the loop with a written discharge dose and a safety-net for the family.
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You are the paediatric registrar on the ward overnight. A six-year-old boy, 21 kg, has just been admitted after reduction and backslabbing of a displaced both-bone forearm fracture. He is tearful and guarding the arm, drinking small sips of water, and has a fever of 38.8 °C with a coryzal viral illness. The ward nurse asks you to confirm the analgesic and antipyretic plan and to calculate the doses. A medical student suggests alternating paracetamol and ibuprofen every two hours and offers aspirin for the fever. [2]
You have ten minutes to: confirm the weight and score the pain; choose and calculate the analgesic and antipyretic doses with the adult ceiling; take a position on the alternating suggestion and the aspirin offer; plan the opioid escalation and its monitoring if simple analgesia is inadequate; and prepare the discharge communication and safety-net. [2]
References7ShowHide
- [1]De la Cruz-Mena JE, Veroniki AA, Acosta-Reyes J, et al. Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis Pediatrics, 2024.PMID 39318339
- [2]Paul IM, Walson PD Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review Curr Med Res Opin, 2021.PMID 33966545
- [3]Rainsford KD Ibuprofen: pharmacology, efficacy and safety Inflammopharmacology, 2009.PMID 19949916
- [6]Schrör K Aspirin and Reye syndrome: a review of the evidence Paediatr Drugs, 2007.PMID 17523700
- [7]Kohler JE, Cartmill RS, Kalbfell E, et al. Continued Prescribing of Periprocedural Codeine and Tramadol to Children after a Black Box Warning J Surg Res, 2020.PMID 32693330
- [11]Pillai Riddell RR, Bucsea O, Shiff I, et al. Non-pharmacological management of infant and young child procedural pain Cochrane Database Syst Rev, 2023.PMID 37314064
- [12]Parikh JM, Amolenda P, Rutledge J, et al. An update on the safety of prescribing opioids in pediatrics Expert Opin Drug Saf, 2019.PMID 30650988