O&G · Gynaecological surgery — uterus-sparing procedures
Myomectomy
Also known as Myomectomy · Abdominal myomectomy · Laparoscopic myomectomy · Hysteroscopic myomectomy · Robotic myomectomy · Uterine fibroids surgery · Uterus-sparing fibroid surgery · Power morcellation · Contained morcellation · In-bag morcellation
Exam-exhaustive FRANZCOG fellowship reference on myomectomy — indications, FIGO type-to-route mapping (hysteroscopic 0-2, laparoscopic or abdominal 3-7), pre-operative optimisation (iron, GnRH analogues), operative technique step by step (vasopressin 20 IU, uterine tourniquet, hysterotomy, enucleation along the pseudocapsule, multi-layer closure, barrier agents, contained in-bag morcellation), complications (bleeding, visceral injury, conversion, uterine rupture), the morcellation controversy (RANZCOG C-Gyn 33, FDA April 2014 Safety Communication, occult leiomyosarcoma 0.01-0.08%, in-bag technique), recurrence 15-30% at 5 years, and the alternative uterus-sparing options (UAE, HIFU/MRgFUS, RFA). RANZCOG-primary, globally tagged.
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Target exams
Red flags
- Rapidly enlarging fibroid with elevated LDH, ill-defined MRI margins, restricted diffusion — assume occult leiomyosarcoma and DO NOT morcellate
- Postmenopausal woman with a new or growing fibroid — assume malignancy until proven otherwise; do not morcellate
- Bleeding that does not respond to vasopressin and uterotonics — escalate to balloon tamponade, interventional radiology, then hysterectomy
- Ureteric or thermal bowel injury — recognise intraoperatively and repair with appropriate specialist input
- Pain and bleeding in a subsequent pregnancy after laparoscopic myomectomy with breach of the cavity — uterine rupture until proven otherwise
- Conversion to laparotomy is not a complication — persisting with a difficult laparoscopic myomectomy that is bleeding is
You are the gynaecology registrar. A 34-year-old nullipara wants to preserve her fertility but has a 10-week-size uterus with a dominant 7 cm posterior intramural fibroid and a 3 cm FIGO type 1 submucous fibroid causing heavy menstrual bleeding and anaemia. She wants a uterus-sparing operation, has a BMI of 32, and has had no prior surgery. She has heard the word "morcellation" on the internet and asks if it is safe. That is the brief for this topic.[2][3]
Overview and definition
Myomectomy is the surgical enucleation of leiomyoma(s) from the uterus with uterine conservation. It is the operation of choice for symptomatic fibroids in women who want to preserve their uterus or their fertility, and it competes with uterine artery embolisation (UAE), MRI-guided focused ultrasound (HIFU/MRgFUS), radiofrequency ablation (RFA), and — when family is complete — hysterectomy.[15]
Three routes are in routine practice, and the route is dictated by the FIGO type, the size, the number, and the operator's expertise:[7]
- Hysteroscopic myomectomy — through the cervix, no abdominal incision. First-line for FIGO type 0, 1 and selected 2 (cavity-distorting submucous fibroids).
- Laparoscopic (or robotic) myomectomy — through 3–4 ports, contained specimen extraction. For FIGO 3, 4, 5 and 6, in appropriately selected uteri.
- Abdominal (open) myomectomy — pfannenstiel or midline laparotomy. For very large uteri (>14–16-week size), multiple >5 fibroids, cervical or broad-ligament location, or when laparoscopic skill or visualisation is limited.
References25ShowHide
- [1]Kathopoulis N, Prodromidou A, Douligeris A, et al. Barbed Sutures Compared With Conventional Sutures During Laparoscopic Myomectomy: A Systematic Review and Meta-analysis Obstet Gynecol, 2024.PMID 39146537
- [2]Clark NM, Schembri M, Jacoby VL Change in Surgical Practice for Women With Leiomyomas After the U.S. Food and Drug Administration Morcellator Safety Communication Obstet Gynecol, 2017.PMID 29016511
- [3]Pritts EA, Parker WH, Brown J, et al. Outcome of occult uterine leiomyosarcoma after surgery for presumed uterine fibroids: a systematic review J Minim Invasive Gynecol, 2015.PMID 25193444
- [4]Devassy R, Devassy RR, de Wilde MS, et al. The Future of Minimal-Access Myoma Surgery with In-Bag Contained Morcellation J Clin Med, 2023.PMID 37297823
- [5]Balachandran A, Mishra RK, Effie AO, et al. A systematic review and meta-analysis of efficacy of vasopressin as a vasoconstrictive and uterotonic drug in laparoscopic myomectomy J Minim Access Surg, 2024.PMID 39724600
- [6]Zapardiel I, Boria F, Halaska MJ, et al. Laparoscopic Power Morcellation: Techniques to Avoid Tumoral Spread J Minim Invasive Gynecol, 2021.PMID 32961359
- [7]AAGL Advancing Minimally Invasive Gynecology Worldwide AAGL position statement: route of hysterectomy to treat benign uterine disease J Minim Invasive Gynecol, 2011.PMID 21059487
- [8]Xu X, Lin H, Wright JD, Gross CP, Boscoe FP, Hutchison LM, Schwartz PE, Desai VB Association Between Power Morcellation and Mortality in Women With Unexpected Uterine Cancer Undergoing Hysterectomy or Myomectomy J Clin Oncol, 2019.PMID 31518176
- [9]Jorgensen EM, Modest AM, Hur HC, Hacker MR, Awtrey CS Hysterectomy Practice Patterns in the Postmorcellation Era Obstet Gynecol, 2019.PMID 30870280
- [10]Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas J Gynecol Obstet Hum Reprod, 2021.PMID 33217603
- [11]Rey Valzacchi GM, Rosas P, Uzal M, Gil SJ, Viglierchio VT Incidence of Leiomyosarcoma at Surgery for Presumed Uterine Myomas in Different Age Groups J Minim Invasive Gynecol, 2020.PMID 31260748
- [12]Surace A, Baù MG, Privitera S, Botta G, Danese S, Plazzotta C, Mitidieri M, Picardo E Risk of unexpected uterine leiomyosarcoma during laparoscopic procedures: Experience from a single tertiary institute in Italy Int J Gynaecol Obstet, 2022.PMID 33834486
- [13]Allameh Z, Afzali S, Jafarpisheh M, Movahedi M, Mousavi Seresht L Evaluation of the Efficacy and Complications of Uterine Artery Embolization in Comparison with Laparotomy-Myomectomy in the Treatment of Uterine Myomas Med J Islam Repub Iran, 2022.PMID 36128265
- [14]Pritts TL, Ogden M, Parker W, Ratcliffe J, Pritts EA Intramural Leiomyomas and Fertility: A Systematic Review and Meta-Analysis Obstet Gynecol, 2024.PMID 38935974
- [15]Pritts EA Uterine Leiomyomas and Reproduction Obstet Gynecol, 2025.PMID 39326048
- [16]Munro MG, Storz K, Abbott JA, et al. AAGL Practice Report: Practice Guidelines for the Management of Hysteroscopic Distending Media J Minim Invasive Gynecol, 2013.PMID 23465255
- [17]De Silva PM, Smith PP, Cooper NAM, Clark TJ Outpatient Hysteroscopy: Green-top Guideline no. 59 BJOG, 2024.PMID 39160077
- [18]Bofill Rodriguez M, Lethaby A, Grigore M, Brown J, Hickey M, Farquhar C Endometrial resection and ablation techniques for heavy menstrual bleeding Cochrane Database Syst Rev, 2019.PMID 30667064
- [19]Tan YH, Lethaby A Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding Cochrane Database Syst Rev, 2013.PMID 24234875
- [20]Kho KA, Lin K, Hechanova M, Richardson DL Risk of Occult Uterine Sarcoma in Women Undergoing Hysterectomy for Benign Indications Obstet Gynecol, 2016.PMID 26855091
- [21]Ibrahim S, Patel B, Karim MR A Comparison of Clinical Outcomes Between Laparoscopic and Open Abdominal Myomectomy in Women With Multiple Symptomatic Uterine Fibroids: A Systematic Review and Meta-Analysis Cureus, 2025.PMID 41268029
- [22]de Bruijn AM, Ankum WM, Reekers JA, Birnie E, van der Kooij SM, Volkers NA, Hehenkamp WJ Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 10-year outcomes from the randomized EMMY trial Am J Obstet Gynecol, 2016.PMID 27393268
- [23]Fonseca MCM, Castro R, Machado M, Conte T, Girao MJBC Uterine Artery Embolization and Surgical Methods for the Treatment of Symptomatic Uterine Leiomyomas: A Systemic Review and Meta-analysis Followed by Indirect Treatment Comparison Clin Ther, 2017.PMID 28641997
- [24]Ahmad G, Kim K, Thompson M, Agarwal P, O'Flynn H, Hindocha A, Watson A Barrier agents for adhesion prevention after gynaecological surgery Cochrane Database Syst Rev, 2020.PMID 32199406
- [25]Multinu F, Casarin J, Tortorella L, Huang Y, Weaver A, Angioni S, Melis GB, Mariani A, Stewart EA, Laughlin-Tommaso SK Incidence of sarcoma in patients undergoing hysterectomy for benign indications: a population-based study Am J Obstet Gynecol, 2019.PMID 30447212