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O&G SAQsIntrapartum care — preterm birth prevention

O&G SAQs · Intrapartum care — preterm birth prevention

Cervical cerclage — structured SAQ (15 marks)

FRANZCOG-format structured SAQ on cervical cerclage: the three indications with their evidence (history, ultrasound, rescue), the three pre-procedure questions and contraindications, McDonald versus Shirodkar with C-STICH and MAVRIC, and PPROM with a suture in situ (Zullo). Per-sub-part marking rubric included.

15 marks20 min4 min readVerification in progress

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FRANZCOGMRCOGABOG
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Target exams

FRANZCOGMRCOGABOG
Prompt
You are the registrar in a preterm birth prevention clinic. A 31-year-old G4P2 is reviewed at 20 weeks. Her obstetric history: a spontaneous preterm birth at 30 weeks (live child), a second-trimester loss at 21 weeks after painless cervical dilatation, and an early first-trimester miscarriage. Today her transvaginal cervical length measures 17 mm with no funnelling, intact membranes, no contractions, normal observations and a negative infection screen. The fetus is structurally normal on the anatomy scan. (a) Classify the three cerclage indications and state which applies here, with the trigger and the evidence base for each. (4 marks) (b) State the three clinical questions you must answer before placing any cerclage, and list four further contraindications. (3 marks) (c) She consents to an ultrasound-indicated cerclage. Compare McDonald and Shirodkar techniques, and quote the suture-material and the high-vs-low-vaginal evidence. (5 marks) (d) Three weeks later she presents with preterm prelabour rupture of membranes at 23 weeks, afebrile and well. Counselled on retain versus remove, what is your default and what does the Zullo meta-analysis say? (3 marks)

How this SAQ is marked

Cerclage answers are graded on discrimination, not enthusiasm. Name the indication and why the others do not apply. State the three exclusions before the technique. Give the number for that indication. Then say when you will take it out. Answer in labelled points. [1]

Reveal model answer and mark schemeShowHide

(a) The three indications and which applies here (4 marks)

One mark for the correct identification (ultrasound-indicated), and one mark each for the trigger, timing and evidence base of the three indications. [1][2][3]

TypeTriggerTimingEvidence base
History-indicatedOne or more prior spontaneous preterm births and/or mid-trimester losses, absent labour or abruption; or prior cerclage for painless second-trimester dilatationPlanned, while asymptomaticMRC/RCOG trial; Cochrane review
Ultrasound-indicatedSingleton, prior spontaneous preterm birth, cervical length under 25 mm before 24 weeksWhen the short cervix is detectedBerghella meta-analysis; Owen trial
Rescue (examination-indicated)Dilated cervix with exposed membranes, no infection, no contractionsImmediately, as a salvage procedureAlthuisius CIPRACT; Ehsanipoor meta-analysis
[1][3][5]

This woman meets the ultrasound-indicated criteria squarely — a singleton, a prior spontaneous preterm birth before 34 weeks, and a transvaginal cervical length of 17 mm before 24 weeks. Note that on the Queensland Clinical Guidelines history criterion (one or more prior spontaneous preterm births and/or mid-trimester losses) she would also qualify on history alone; the two routes are not mutually exclusive, and the mark is for recognising that the short cervix in this specific population is where the randomised evidence is strongest. The Berghella meta-analysis in exactly this population reduced preterm birth before 35 weeks from 41.3% to 28.4% (RR 0.70, 95% CI 0.55 to 0.89), with composite perinatal mortality and morbidity down from 24.8% to 15.6% (RR 0.64, 95% CI 0.45 to 0.91).[1][3]

(b) Three questions and four further contraindications (3 marks)

One mark for the three questions, and half a mark each for any four further contraindications (totalling two marks). [1][8]

The three questions before any cerclage: Is there infection? Are the membranes ruptured? Is she contracting? A yes to any one means no cerclage. Phrase all three so that "yes" is the answer that stops you — a candidate who asks "are the membranes intact?" and then says "yes means no cerclage" has just contraindicated every safe case.[1]

Four further contraindications (any four): active uterine contractions or established preterm labour; clinical chorioamnionitis (fever, maternal or fetal tachycardia, uterine tenderness, offensive discharge); ruptured membranes; active vaginal bleeding or suspected abruption; a lethal fetal anomaly or confirmed fetal demise; gestation beyond the point at which the procedure can plausibly help (around 24 weeks for rescue).[1][8]

(c) McDonald versus Shirodkar, suture material, and high versus low vaginal cerclage (5 marks)

One mark each for: McDonald technique; Shirodkar technique; the comparative practical point (knot, bladder, removal); C-STICH suture material result; and MAVRIC high versus low vaginal result. [1][5][6]

  • McDonald (transvaginal, low): purse-string suture at the cervicovaginal junction, as high as practicable, taking four to five bites and avoiding the bladder anteriorly and the rectum posteriorly. Knot tied anteriorly with ends left long for easy removal; the workhorse, usually removed as an outpatient.[1]
  • Shirodkar (transvaginal, high): anterior and posterior colpotomies allow the bladder to be reflected upward so the suture sits at the level of the internal os, with the knot buried. Takes longer, bleeds more, and often needs anaesthesia for removal.[1]
  • Comparative: no proven superiority of Shirodkar over McDonald — the choice is largely operator preference.[1]
  • C-STICH (suture material): monofilament versus braided in 2049 women — pregnancy loss 8.0% versus 7.6% (adjusted RR 1.05, 95% CI 0.79 to 1.40), no significant difference. Use what you are competent with.[5]
  • MAVRIC (high versus low vaginal): in women with a previous failed cerclage, high vaginal cerclage was no better than low vaginal (birth before 32 weeks 38% versus 33%, RR 1.15, 95% CI 0.62 to 2.16) — only transabdominal cerclage was superior in that population.[6]

(d) PPROM with a suture in situ (3 marks)

One mark for the default (removal), one mark for the latency finding, and one mark for the infection and neonatal finding. [7]

  • Default: remove the suture, give broad-spectrum antibiotics and steroids as indicated by gestation, and deliver if infection develops. Short-term retention might be considered only at an extremely early gestation with no clinical or biochemical evidence of infection, after a consultant discussion with neonatology and the woman, with an explicit trigger to remove.[1][7]
  • Latency: the Zullo meta-analysis (six studies, 377 women) found retention did prolong pregnancy — the removal group had significantly lower prolongation beyond 48 hours (OR 0.15) and beyond 7 days (OR 0.30).[7]
  • Infection and neonatal cost: retention significantly increased chorioamnionitis (OR 0.57 favouring removal) and a 5-minute Apgar under 7 (OR 0.22 favouring removal). Retention buys latency but costs infection and a worse baby at birth.[7]
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References8ShowHide
  1. [1]Shennan AH, Story L Cervical Cerclage: Green-top Guideline No. 75 BJOG, 2022.PMID 35199905
  2. [2]MRC/RCOG Working Party on Cervical Cerclage Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists multicentre randomised trial of cervical cerclage. MRC/RCOG Working Party on Cervical Cerclage Br J Obstet Gynaecol, 1993.PMID 8334085
  3. [3]Berghella V, Rafael TJ, Szychowski JM, et al. Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: a meta-analysis Obstet Gynecol, 2011.PMID 21446209
  4. [4]To MS, Alfirevic Z, Heath VC, et al. Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial Lancet, 2004.PMID 15183621
  5. [5]Hodgetts Morton V, Toozs-Hobson P, Moakes CA, et al. Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial Lancet, 2022.PMID 36273481
  6. [6]Shennan A, Chandiramani M, Bennett P, et al. MAVRIC: a multicenter randomized controlled trial of transabdominal vs transvaginal cervical cerclage Am J Obstet Gynecol, 2020.PMID 31585096
  7. [7]Zullo F, Di Mascio D, Chauhan SP, et al. Removal versus retention of cervical cerclage with preterm prelabor rupture of membranes: Systematic review and meta-analysis Eur J Obstet Gynecol Reprod Biol, 2023.PMID 37481990
  8. [8]Ehsanipoor RM, Seligman NS, Saccone G, et al. Physical Examination-Indicated Cerclage: A Systematic Review and Meta-analysis Obstet Gynecol, 2015.PMID 26241265
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