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ICU TopicsTrauma / neurocritical care

ICU · Trauma / neurocritical care

Spinal Trauma & Spinal Shock — ASIA Scale, CT vs MRI & Steroid Controversy

Also known as Spinal cord injury · SCI · Spinal shock · Neurogenic shock · ASIA impairment scale · NASCIS · Methylprednisolone spinal injury · Cervical spine clearance · Complete cord syndrome · Anterior cord syndrome · Central cord syndrome · Brown-Séquard syndrome · NEXUS criteria · Canadian C-spine rule · STASCIS · Autonomic dysreflexia

The spinal trauma and the spinal shock in the ICU: the spinal cord injury (the SCI — from the trauma, the fracture, the dislocation) causing the motor and sensory deficit below the level. The mechanism of injury (the axial loading, the flexion, the extension, the rotation, the distraction) determines the fracture pattern and the cord injury. The ASIA impairment scale (A = complete; B = sensory incomplete; C = motor incomplete; D = motor useful; E = normal). The spinal shock (the temporary the areflexia and the flaccidity below the level — the resolves over the days to the weeks) vs the neurogenic shock (the hypotension, the bradycardia, the vasodilation from the loss of the sympathetic tone — the T6 and above). The cervical spine clearance (the NEXUS low-risk criteria vs the Canadian C-spine rule; the CT first-line for the high-risk; the MRI for the neurological deficit; the clinical clearance for the low-risk). The imaging: the CT first (the bony), the MRI for the cord (the oedema, the haematoma, the compression). The steroids (the methylprednisolone — the NASCIS trials; the controversial; the not the standard of the care).

high20 referencesUpdated 26 July 202628 min readVerification in progress

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Overview & definition

Spinal cord injury (SCI) is traumatic damage to the cord producing a motor and sensory deficit below the level. The ICU has two priorities: (1) prevent secondary injury from hypoperfusion, hypoxia and hypotension, and (2) augment the mean arterial pressure — the 2024 AO Spine guideline suggests at least 75–80 mmHg as the lower limit, not actively augmented beyond 90–95 mmHg, for 3–7 days — to perfuse the injured cord. Severity is graded by the ASIA impairment scale. Neurogenic shock — hypotension with bradycardia from loss of sympathetic tone at T6 and above — needs vasopressors. Steroids are controversial and not a standard practice: NASCIS II found better motor and sensory recovery only when started within 8 hours (mortality and major morbidity similar to placebo), and NASCIS III linked its 48-hour regimen to more severe sepsis and severe pneumonia.[1][13][7][8]

The primary injury — the mechanical cord damage at the moment of impact (the compression, contusion, shear, laceration) — is irreversible; the ICU cannot undo it. Everything in the first week is directed at the secondary injury cascade: the ischaemia, oedema, excitotoxicity (glutamate), the calcium influx, the free-radical lipid peroxidation, the apoptosis — all amplified by hypotension, hypoxia, hypoglycaemia and hyperthermia. Every hypotensive episode threatens the ischaemic penumbra, which is why MAP augmentation is recommended for days after injury and why a single hypotensive episode is treated as a neurological emergency.[1][13]

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  1. [1]Galeiras Vázquez R, Ferreiro Velasco ME, Mourelo Fariña M, et al. Update on traumatic acute spinal cord injury. Part 1. 2017.PMID 28161028
  2. [2]Como JJ, Diaz JJ, Dunham CM, et al. Practice management guidelines for identification of cervical spine injuries following trauma: update from the eastern association for the surgery of trauma practice management guidelines committee. The Journal of trauma, 2009.PMID 19741415
  3. [3]Hoffman JR, Mower WR, Wolfson AB, et al. Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma. National Emergency X-Radiography Utilization Study Group. The New England journal of medicine, 2000.PMID 10891516
  4. [4]Stiell IG, Wells GA, Vandemheen KL, et al. The Canadian C-spine rule for radiography in alert and stable trauma patients. JAMA, 2001.PMID 11597285
  5. [5]Kirshblum SC, Burns SP, Biering-Sorensen F, et al. International standards for neurological classification of spinal cord injury (ASIA standards, revised 2011). Journal of Spinal Cord Medicine, 2011.PMID 22330108
  6. [6]Fehlings MG, Vaccaro A, Wilson JR, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PloS one, 2012.PMID 22384132
  7. [7]Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. The New England journal of medicine, 1990.PMID 2278545
  8. [8]Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA, 1997.PMID 9168289
  9. [9]Hadley MN, Walters BC, Grabb PA, et al. Pharmacological therapy after acute cervical spinal cord injury. Neurosurgery, 2002.PMID 12431289
  10. [10]Malhotra A, Durand D, Wu X, et al. Utility of MRI for cervical spine clearance in blunt trauma patients after a negative CT. European radiology, 2018.PMID 29450715
  11. [11]Galvagno SM Jr, Nahmias JT, Young DA Advanced Trauma Life Support(®) Update 2019: Management and Applications for Adults and Special Populations. Anesthesiology clinics, 2019.PMID 30711226
  12. [13]Kwon BK, Tetreault LA, Martin AR, et al. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management. Global spine journal, 2024.PMID 38526923
  13. [15]Hachem LD, Ahuja CS, Fehlings MG Assessment and management of acute spinal cord injury: From point of injury to rehabilitation. The journal of spinal cord medicine, 2017.PMID 28571527
  14. [16]Consortium for Spinal Cord Medicine Acute management of autonomic dysreflexia: individuals with spinal cord injury presenting to health-care facilities. The journal of spinal cord medicine, 2002.PMID 12051242
  15. [17]Satkunendrarajah K, Karadimas SK, Fehlings MG Spinal cord injury and degenerative cervical myelopathy. Handbook of clinical neurology, 2022.PMID 36031307
  16. [18]Chiodo AE, Scelza W, Forchheimer M Predictors of ventilator weaning in individuals with high cervical spinal cord injury. The journal of spinal cord medicine, 2008.PMID 18533415
  17. [19]Godat LN, Haut ER, Moore EE, et al. Venous thromboembolism risk after spinal cord injury: A secondary analysis of the CLOTT study. The journal of trauma and acute care surgery, 2023.PMID 36203245
  18. [20]Epstein NE Review/Perspective: Operations for Cauda Equina Syndromes - "The Sooner the Better". Surgical neurology international, 2022.PMID 35399881
  19. [21]Yue JK, Tsolinas RE, Burke JF, et al. Vasopressor support in managing acute spinal cord injury: current knowledge. Journal of neurosurgical sciences, 2019.PMID 28252264
  20. [22]Yokose M, Sangawa M, Shiomi H, et al. Initial Dose of Intravenous Atropine for Patients With Symptomatic Bradycardia: A Scoping Review. Circulation reports, 2025.PMID 41216404

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