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ICU TopicsTrauma

ICU · Trauma

Damage-Control Resuscitation & Surgery — The Lethal Triad & Planned Re-operation

Also known as Damage-control resuscitation · DCR · Damage-control surgery · DCS · Lethal triad · Permissive hypotension · Open abdomen · Planned re-operation · Abbreviated laparotomy

Damage-control resuscitation (DCR) and damage-control surgery (DCS) — the integrated approach to the exsanguinating trauma patient. DCR: the permissive hypotension (SBP 80 to 90 until the bleeding controlled), the MTP 1:1:1 (RBC:plasma:platelets), the TXA within 3 hours, the minimise the crystalloid (worsens dilutional coagulopathy and the acidosis), the warm. DCS: the abbreviated the laparotomy (the packing to control the bleeding, the temporary the closure, NOT definitive repair), the correct the lethal triad (the acidosis, the hypothermia, the coagulopathy), and the planned the re-operation at the 24 to 48 hours (the definitive the repair, the anastomosis, the closure). The open the abdomen (the manage the intra-abdominal the hypertension, the fistula, the fluid the losses).

high15 referencesUpdated 26 July 202614 min readVerification in progress

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Overview & definition

Damage-control resuscitation (DCR) and damage-control surgery (DCS) are the integrated response to the exsanguinating trauma patient. The single principle: stop the bleeding FAST, correct the lethal triad, and DEFER the definitive repair. DCR addresses the physiology; DCS addresses the anatomy. The lethal triad of acidosis, hypothermia, and coagulopathy drives the mortality — break it early, then return for definitive repair at a planned re-operation in 24-48 hours.[1]

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  1. [1]Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma J Trauma, 2007.PMID 17297317
  2. [2]Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial JAMA, 2015.PMID 25647203
  3. [3]Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet, 2010.PMID 20554319
  4. [4]Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial Lancet, 2011.PMID 21439633
  5. [5]Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study Arch Surg, 2012.PMID 22006852
  6. [6]Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis J Trauma, 2008.PMID 18469643
  7. [7]Cannon JW, Khan MA, Raja AS, et al. Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma J Trauma Acute Care Surg, 2017.PMID 28225743
  8. [8]Spahn DR, Bouillon B, Cerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition Crit Care, 2019.PMID 30917843
  9. [9]Brill JB, Brenner M, Duchesne J, et al. The Role of TEG and ROTEM in Damage Control Resuscitation Shock, 2021.PMID 33769424
  10. [10]Rotondo MF, Schwab CW, McGonigal MD, et al. 'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury J Trauma, 1993.PMID 8371295
  11. [11]Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries N Engl J Med, 1994.PMID 7935634
  12. [12]Dutton RP, Mackenzie CF, Scalea TM Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality J Trauma, 2002.PMID 12045644
  13. [13]Chesnut RM, Marshall LF, Klauber MR, et al. The role of secondary brain injury in determining outcome from severe head injury J Trauma, 1993.PMID 8459458
  14. [14]Innerhofer P, Fries D, Mittermayr M, et al. Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial Lancet Haematol, 2017.PMID 28457980
  15. [15]Davenport R, Curry N, Fox EE, et al. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial JAMA, 2023.PMID 37824155

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