ICU · Transplant / immunology

Solid-Organ Transplant Recipient in the ICU — Immunosuppression, Infection & Rejection

Also known as Solid-organ transplant · Transplant recipient · Immunosuppression · Tacrolimus · Ciclosporin · Mycophenolate · Acute rejection · Opportunistic infection · Calcineurin inhibitor

The solid-organ transplant recipient in the ICU: the immunosuppression (the calcineurin inhibitors — the tacrolimus, the ciclosporin; the antimetabolites — the mycophenolate; the mTOR — the sirolimus; the steroids), the infection risk (the timeline — the first month the nosocomial; the 1 to 6 months the opportunistic — the CMV, the PCP, the Listeria, the Aspergillus; the late the community-acquired), the acute rejection (the T-cell mediated — the cellular; the antibody-mediated — the humoral), the drug interactions (the CYP3A4 — the tacrolimus levels), and the graft dysfunction (the diagnostic — the ultrasound, the biopsy).