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ICU TopicsToxicology

ICU · Toxicology

Envenomation — Snake, Spider & Marine (ANZ)

Also known as Snake bite · Venom-induced consumption coagulopathy · VICC · Pressure-immobilisation · Funnel-web spider · Redback spider · Box jellyfish · Snake antivenom

The Australian envenomation — the snake (the elapid — the brown, the tiger, the taipan, the death adder; the venom-induced consumption coagulopathy / the VICC, the neurotoxicity, the myotoxicity, the sudden collapse), the spider (the funnel-web — the robustoxin, the life-threatening; the redback — the latrotoxin, the painful), and the marine (the box jellyfish — the cardiotoxic; the blue-ringed octopus — the tetrodotoxin paralysis). The pressure-immobilisation, the venom detection kit, the antivenom. The ANZ (the CICM) emphasis.

high24 referencesUpdated 20 Aug 202611 min readVerification in progress

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Australian envenomation splits three ways — snake (the elapids: brown, tiger, taipan, death adder, mulga), spider (the funnel-web and the redback), and marine (the box jellyfish and the blue-ringed octopus). The snake syndromes are venom-induced consumption coagulopathy (an unmeasurable INR with consumed clotting factors and a HIGH D-dimer — the factors resynthesise over the days that follow), neurotoxicity (ptosis descending to respiratory paralysis), myotoxicity, and the sudden collapse of the brown snake. First aid is PRESSURE-IMMOBILISATION for the snake and funnel-web (it delays lymphatic spread), the venom detection kit identifies the genus, and the monovalent antivenom is the cure. Pressure-immobilisation is WRONG for the redback (latrotoxin is local) and the box jellyfish (use vinegar).[1]

Meet the patient

A 9-year-old boy is bitten on the finger by a Sydney funnel-web while lifting a log. Within twenty minutes he is salivating, lacrimating, sweating profusely, fasciculating, hypertensive (160/100) and progressively bradycardic. Across the country, a stockman bitten on the ankle by an unseen snake has a normal first blood count at one hour — and an unrecordable INR by the third.[1]

The two questions that govern every Australian bite are the ones these vignettes turn on: which animal, and has venom actually been injected? Roughly half of snakebites are dry. The pressure-immobilisation bandage, the venom detection kit, and the antivenom answer the rest — but only if you observe long enough to let the venom declare itself.[1]

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References24ShowHide
  1. [1]Stewart CJ Snake bite in Australia: first aid and envenomation management Accid Emerg Nurs, 2003.PMID 12633629
  2. [2]Park EJ, Choi S, Kim HH, et al. Novel Treatment Strategy for Patients with Venom-Induced Consumptive Coagulopathy from a Pit Viper Bite Toxins (Basel), 2020.PMID 32380672
  3. [3]Isbister GK, et al. Antivenom efficacy or effectiveness: the Australian experience Toxicology, 2010.PMID 19782716
  4. [4]Johnston CI, Ryan NM, Page CB, et al. The Australian Snakebite Project, 2005-2015 (ASP-20) Med J Aust, 2017.PMID 28764620
  5. [5]Ryan NM, Kearney RT, Brown SG, Isbister GK Incidence of serum sickness after the administration of Australian snake antivenom (ASP-22) Clin Toxicol (Phila), 2016.PMID 26490786
  6. [6]Isbister GK, Brown SG, MacDonald E, et al. Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis Med J Aust, 2008.PMID 18429716
  7. [7]de Silva HA, Ryan NM, de Silva HJ Adverse reactions to snake antivenom, and their prevention and treatment Br J Clin Pharmacol, 2016.PMID 26256124
  8. [8]Isbister GK, Jayamanne S, Mohamed F, et al. A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming J Thromb Haemost, 2017.PMID 28106331
  9. [9]Maduwage K, Isbister GK Current treatment for venom-induced consumption coagulopathy resulting from snakebite PLoS Negl Trop Dis, 2014.PMID 25340841
  10. [10]Currie BJ, Jacups SP Prospective study of Chironex fleckeri and other box jellyfish stings in the Top End of Australia's Northern Territory Med J Aust, 2005.PMID 16336157
  11. [11]Fenner PJ, Williamson JA, Burnett JW, Rifkin J First aid treatment of jellyfish stings in Australia. Response to a newly differentiated species Med J Aust, 1993.PMID 8469205
  12. [12]McCullagh N, Pereira P, Cullen P, et al. Randomised trial of magnesium in the treatment of Irukandji syndrome Emerg Med Australas, 2012.PMID 23039299
  13. [13]Rathbone J, Franklin R, Gibbs C, Williams D Role of magnesium sulphate in the management of Irukandji syndrome: a systematic review Emerg Med Australas, 2017.PMID 27748058
  14. [14]Cavazzoni E, Lister B, Sargent P, Schibler A Blue-ringed octopus (Hapalochlaena sp.) envenomation of a 4-year-old boy: a case report Clin Toxicol (Phila), 2008.PMID 19238736
  15. [15]Currie BJ Marine antivenoms J Toxicol Clin Toxicol, 2003.PMID 12807313
  16. [16]Isbister GK, Gray MR, Balit CR, et al. Funnel-web spider bite: a systematic review of recorded clinical cases Med J Aust, 2005.PMID 15850438
  17. [17]Isbister GK, Page CB, Buckley NA, et al. Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: the second Redback Antivenom Evaluation (RAVE-II) study Ann Emerg Med, 2014.PMID 24999282
  18. [18]Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020 World Allergy Organ J, 2020.PMID 33204386
  19. [19]Boyle RJ, Elremeli M, Hockenhull J, et al. Venom immunotherapy for preventing allergic reactions to insect stings Cochrane Database Syst Rev, 2012.PMID 23076950
  20. [20]Betten DP, Richardson WH, Tong TC, Clark RF Massive honey bee envenomation-induced rhabdomyolysis in an adolescent Pediatrics, 2006.PMID 16396886
  21. [21]Brown JC, Simons E, Rudders SA Epinephrine in the Management of Anaphylaxis J Allergy Clin Immunol Pract, 2020.PMID 32276687
  22. [22]Maduwage K, Kodagoda Gamage S, Gutiérrez JM First aid and pre-hospital practices in snakebite victims: The persistent use of harmful interventions Toxicon, 2024.PMID 38128838
  23. [23]Berling I, Isbister GK Hematologic effects and complications of snake envenoming Transfus Med Rev, 2015.PMID 25556574
  24. [24]Hifumi T, Fukuchi Y, Otani N, et al. Clinical characteristics of stonefish "Oni-daruma-okoze" envenomation in Japan Acute Med Surg, 2020.PMID 32528708

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