ICU · Statistics & evidence-based medicine

Guidelines, Evidence-Based Medicine & Quality-Improvement Methodology

Also known as Evidence-based medicine · GRADE · GRADE Evidence to Decision · Clinical guidelines · Guideline development · Quality improvement · PDSA cycle · AGREE II · PICO · Care bundles · Evidence hierarchy · Systematic review · Critical appraisal · CASP · CONSORT · PRISMA · STROBE · Bias · Implementation science · Knowledge translation · CFIR · PARIHS

Guidelines, EBM and quality improvement for the ICU First Part: evidence-based medicine as the integration of best evidence, clinical expertise and patient values; the PICO question and the evidence hierarchy; the GRADE approach to evidence quality (high/moderate/low/very low), recommendation strength (strong/weak), downgrading and upgrading domains, and the Evidence to Decision framework; the guideline-development pipeline from PICO to systematic review to evidence profile to graded recommendation; guideline appraisal (AGREE II); critical appraisal tools (CASP checklists) and reporting guidelines (CONSORT, PRISMA, STROBE); implementation science (knowledge-to-action, CFIR, PARIHS); and QI methodology - PDSA cycles, care bundles, audit and feedback, and the structure-process-outcome framework.