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ICU TopicsTrauma & burns

ICU · Trauma & burns

Trauma, Burns and Mass-Casualty Resuscitation

Also known as Trauma · Major trauma · Burns · Parkland formula · Damage-control surgery · Mass casualty · START triage · Injury Severity Score

Trauma is the time-critical failure of mechanical integrity — of the circulation, the airway, the brain and the skeleton — and its management is the parallel, prioritised, damage-control resuscitation of the ATLS primary survey. This topic builds the examiner's framework on the primary and the secondary survey (the ABCDE), the lethal triad of acidosis-hypothermia-coagulopathy that drives the bleeding to death, the damage-control resuscitation with tranexamic acid and the 1:1:1 transfusion ratio, the burns resuscitation (the Parkland formula and the inhalation injury), the cervical-spine clearance (the Canadian C-spine rule), the traumatic-brain-injury corticosteroid harm (the CRASH trial), the mass-casualty triage (START) and the injury scoring (the ISS and the RTS), and the evidence base — CRASH-2 for tranexamic acid and the Canadian C-spine rule for the clearance of the alert, stable patient.

medium13 referencesUpdated 20 Aug 202636 min readVerification in progress

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The one-line answer

Trauma, burns and mass-casualty is managed by the parallel, prioritised, damage-control resuscitation of the ATLS primary survey — ABCDE, with catastrophic haemorrhage controlled first. The bleeding patient dies of the lethal triad (acidosis, hypothermia, coagulopathy), so resuscitate with blood not saline in a 1:1:1 ratio, give tranexamic acid within 3 hours, and hold permissive hypotension until the bleeding stops. In a mass casualty, triage — the sieve then the sort, START into red, yellow, green and black — and CSCATT before you treat: command and safety first, always.[1][8][9]

Meet the patient

A motorcyclist arrives after a high-speed crash — agitated, pale, cold, an externally bleeding femur fracture and a distended abdomen, blood pressure 70 over 45 that does not budge after a litre of crystalloid. The team reaches for the fluid.[1]

The question that decides his next hour is the question that decides every trauma resuscitation: where is he bleeding, and how do I stop the lethal triad before it stops him? Hold that question and the damage-control discipline slots into place.[1]

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References13ShowHide
  1. [1]Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet, 2010.PMID 20554319
  2. [2]Stiell IG, Wells GA, Vandemheen KL, et al. The Canadian C-spine rule for radiography in alert and stable trauma patients JAMA, 2001.PMID 11597285
  3. [3]Roberts I, Yates D, Sandercock P, et al. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial Lancet, 2004.PMID 15474134
  4. [4]Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N Engl J Med, 1999.PMID 9971864
  5. [5]Abramson DM, Morse SS, Garrett AL, et al. Public health disaster research: surveying the field, defining its future Disaster Med Public Health Prep, 2007.PMID 18388605
  6. [6]Kelly J, Cheng J, Malloy R, et al. Comparison of Positive Inotropic Agents in the Management of Acute Decompensated Heart Failure J Cardiovasc Pharmacol, 2020.PMID 32091426
  7. [7]Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial JAMA, 2015.PMID 25647203
  8. [8]Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial Lancet, 2011.PMID 21439633
  9. [9]Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries N Engl J Med, 1994.PMID 7935634
  10. [10]Blumetti J, Hunt JL, Arnoldo BD, et al. The Parkland formula under fire: is the criticism justified? J Burn Care Res, 2008.PMID 18182919
  11. [11]Shah A, Pedraza I, Mitchell C, et al. Fluid volumes infused during burn resuscitation 1980-2015: a quantitative review Burns, 2020.PMID 31862276
  12. [12]Wise R, Jacobs J, Pilate S, et al. Incidence and prognosis of intra-abdominal hypertension and abdominal compartment syndrome in severely burned patients: pilot study and review of the literature Anaesthesiol Intensive Ther, 2016.PMID 26588479
  13. [13]Cartotto R, Zhou A Fluid creep: the pendulum hasn't swung back yet! J Burn Care Res, 2010.PMID 20616649

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