Skip to main content
MedVellum
QuestionsVideosPricing

MedVellum

Fellowship exam preparation across every specialty: source-verified topics, questions in every format, and videos.

Product

  • Specialties
  • Questions
  • Videos
  • Exam tools
  • Pricing

Verification & policy

  • Verified register
  • Editorial policy
  • Privacy
  • Terms

Account

  • Sign in
  • Create account
  • Dashboard
  • Account & billing

© 2026 MedVellum. For education only — not a substitute for clinical judgement.

llms.txtPsychiatry LLM catalogSitemap

ICU TopicsShock states

ICU · Shock states

Shock States — Classification, Profiles and Management

Also known as Shock · Distributive shock · Cardiogenic shock · Hypovolaemic shock · Obstructive shock · Haemodynamic profiles · Vasopressors

Shock in the ICU: the four types and their treatment principles, critical oxygen delivery, Sepsis-3 septic shock, perfusion markers (lactate, mottling, capillary refill), fluid responsiveness and choice (CLASSIC, CLOVERS), SSC 2021 vasopressor and steroid recommendations with the supporting trials, EGDT and PRISM, time to treatment, cardiogenic shock after MI (SHOCK, IABP-SHOCK II, CULPRIT-SHOCK) and anaphylaxis.

high25 referencesUpdated 8 Oct 20266 min readSource-verified · Oct 2026

Checked against its sources on 8 Oct 2026

Practise this topic

  • 8 MCQs

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDICESICMSociety_CCM
On this page
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDICESICMSociety_CCM

What shock is

A severe mismatch between the supply and demand of oxygen is the common feature of all types of shock.[1] Circulatory shock is a life-threatening syndrome that results in multiorgan failure and a high mortality rate.[2] In anaesthetised adults, oxygen consumption fell in proportion to oxygen delivery once delivery dropped below a critical value of 330 mL/min/m² (8.2 mL/min/kg); above it, consumption plateaued.[5]

Sepsis-3 defines septic shock as a subset of sepsis in which particularly profound circulatory, cellular and metabolic abnormalities carry a greater risk of mortality than sepsis alone; it is identified clinically by a vasopressor requirement to maintain a MAP of 65 mmHg or greater and a serum lactate above 2 mmol/L in the absence of hypovolaemia.[3]

Five anchors
  1. Four categories, four organ systems: hypovolaemic (blood and fluid compartment), distributive (vessels), cardiogenic (heart), obstructive (blockage of the circulation).[1]
  2. Perfusion markers predict death better than pressure: mottling, lactate and oliguria — not MAP, CVP or cardiac index — were associated with 14-day mortality in septic shock.[7]
  3. CVP does not predict fluid responsiveness (pooled ROC area 0.56).[9]
  4. Norepinephrine first, MAP 65 mmHg initially, add vasopressin rather than escalate.[4]
  5. Time matters: each hour to bundle completion or antibiotics raised the odds of in-hospital death by 4%.[21]
ICU Fellowship (CICM) Pro

Continue reading

You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the ICU Fellowship (CICM) fellowship library.

Sign in to continueSee pricing
References25ShowHide
  1. [1]Standl T, Annecke T, Cascorbi I, et al. The Nomenclature, Definition and Distinction of Types of Shock. Deutsches Arzteblatt international, 2018.PMID 30573009
  2. [2]Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive care medicine, 2014.PMID 25392034
  3. [3]Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016.PMID 26903338
  4. [4]Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive care medicine, 2021.PMID 34599691
  5. [5]Shibutani K, Komatsu T, Kubal K, et al. Critical level of oxygen delivery in anesthetized man. Critical care medicine, 1983.PMID 6409505
  6. [6]Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Annals of emergency medicine, 2005.PMID 15855951
  7. [7]Ait-Oufella H, Lemoinne S, Boelle PY, et al. Mottling score predicts survival in septic shock. Intensive care medicine, 2011.PMID 21373821
  8. [8]Hernández G, Ospina-Tascón GA, Damiani LP, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA, 2019.PMID 30772908
  9. [9]Marik PE, Baram M, Vahid B Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest, 2008.PMID 18628220
  10. [10]Michard F, Boussat S, Chemla D, et al. Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. American journal of respiratory and critical care medicine, 2000.PMID 10903232
  11. [11]Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. The New England journal of medicine, 2022.PMID 35709019
  12. [12]National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. The New England journal of medicine, 2023.PMID 36688507
  13. [13]De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock. The New England journal of medicine, 2010.PMID 20200382
  14. [14]Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. The New England journal of medicine, 2008.PMID 18305265
  15. [15]Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock. The New England journal of medicine, 2014.PMID 24635770
  16. [16]Venkatesh B, Finfer S, Cohen J, et al. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. The New England journal of medicine, 2018.PMID 29347874
  17. [17]Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. The New England journal of medicine, 2008.PMID 18184957
  18. [18]Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. The New England journal of medicine, 2001.PMID 11794169
  19. [19]PRISM Investigators, Rowan KM, Angus DC, et al. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. The New England journal of medicine, 2017.PMID 28320242
  20. [20]Jones AE, Shapiro NI, Trzeciak S, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA, 2010.PMID 20179283
  21. [21]Seymour CW, Gesten F, Prescott HC, et al. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. The New England journal of medicine, 2017.PMID 28528569
  22. [22]Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. The New England journal of medicine, 1999.PMID 10460813
  23. [23]Thiele H, Zeymer U, Neumann FJ, et al. Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial. Lancet (London, England), 2013.PMID 24011548
  24. [24]Thiele H, Akin I, Sandri M, et al. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock. The New England journal of medicine, 2017.PMID 29083953
  25. [25]Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020. The World Allergy Organization journal, 2020.PMID 33204386

Test yourself

Practise what you just read

  • 8 MCQs
ICU Fellowship (CICM) Pro

$29/ monthor $279 / year

The complete ICU Fellowship (CICM) library, every exam format, one subscription.

  • Complete library for one chosen specialty
  • Timed MCQ mock exams and spaced review
  • Clinical cases & cross-table vivas
See pricingSign in
PreviousSevere Diarrhoea & C. difficile — Toxins, Severity & the Vancomycin/Fidaxomicin EraGI & nutrition / infectionNextSickle-Cell Crisis — Vaso-Occlusive, Acute Chest & Exchange TransfusionHaematology / haemoglobinopathy