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ICU TopicsResuscitation & shock

ICU · Resuscitation & shock

Neurogenic Shock (Spinal Cord Injury)

Also known as Neurogenic shock · Spinal shock · Spinal cord injury shock · Distributive shock spinal · MAP target spinal cord

Neurogenic shock — the loss of supraspinal sympathetic control after spinal cord injury at or above T6. The vasodilation with venous pooling (the warm, the dry) plus the bradycardia (the unopposed vagal). The MAP target: the traditional 85 to 90 mmHg for up to seven days, refined by the 2024 AO Spine guideline to 75 to 80 mmHg as the lower limit and 90 to 95 mmHg as the upper limit for 3 to 7 days. Noradrenaline commonly preferred where a vasopressor is needed; atropine first-line for symptomatic bradycardia. Distinguish from the hypovolaemic (the warm plus the dry versus the cool plus the clammy) and from spinal shock (the neurological phenomenon).

medium18 referencesUpdated 20 Aug 202619 min readVerification in progress

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Neurogenic shock is the haemodynamic consequence of losing supraspinal sympathetic control after a spinal cord injury at or above T6 — producing the triad no other shock shares: hypotension, bradycardia, and warm dry skin, from sympathetic destruction with unopposed vagal stimulation of the myocardium.[3][2] Manage it with noradrenaline — the agent reviews most commonly prefer for its balanced effects on vascular resistance and cord perfusion[6] — holding the MAP in range guidelines support: the traditional target of 85 to 90 mmHg for up to seven days,[5][1] refined by the 2024 AO Spine guideline to augment MAP to at least 75 to 80 mmHg but not beyond an upper limit of 90 to 95 mmHg, for 3 to 7 days.[4] Give atropine first-line for symptomatic bradycardia (0.5 mg IV is the usual initial dose, and moderate doses up to 1 mg appear safe),[10] and search relentlessly for the co-existent bleed that kills the patient you labelled "just neurogenic."[16]

Meet the patient

A 25-year-old diver surfaces, clutches his neck, and collapses. In the resus bay he is in a cervical collar, BP 80/50, heart rate 42, and his skin below the clavicles is warm, dry, and flushed. The registrar reaches for fluids and calls it hypovolaemic shock — but the heart rate is the clue that changes everything.[3]

Bradycardia with hypotension after a high cord injury is the expected, not the exception: high thoracic and cervical injuries manifest with hypotension plus bradycardia, because the injury destroys sympathetic nervous system activity while vagal stimulation of the myocardium continues unopposed.[3] Traumatic spinal cord injury usually occurs as part of multiple trauma — which is exactly why the diagnosis is never automatic.[16]

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References18ShowHide
  1. [1]Casha S, Christie S A systematic review of intensive cardiopulmonary management after spinal cord injury Journal of Neurotrauma, 2011.PMID 20030558
  2. [2]Furlan JC, Fehlings MG Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management Neurosurgical Focus, 2008.PMID 18980473
  3. [3]Iovine JA, Villanueva RD, Werth CM, et al. Contemporary hemodynamic management of acute spinal cord injuries with intravenous and enteral vasoactive agents: a narrative review American Journal of Health-System Pharmacy, 2022.PMID 35677966
  4. [4]Kwon BK, Tetreault LA, Martin AR, et al. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management Global Spine Journal, 2024.PMID 38526923
  5. [5]Yue JK, Tsolinas RE, Burke JF, et al. Vasopressor support in managing acute spinal cord injury: current knowledge Journal of Neurosurgical Sciences, 2019.PMID 28252264
  6. [6]Taman M, Abdulrazeq H, Chuck C, et al. Vasopressor use in acute spinal cord injury: current evidence and clinical implications Journal of Clinical Medicine, 2025.PMID 39941573
  7. [7]De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock New England Journal of Medicine, 2010.PMID 20200382
  8. [8]Bartholdy K, Biering-Sørensen T, Malmqvist L, et al. Cardiac arrhythmias the first month after acute traumatic spinal cord injury Journal of Spinal Cord Medicine, 2014.PMID 24559419
  9. [9]Rangappa P, Jeyadoss J, Flabouris A, et al. Cardiac pacing in patients with a cervical spinal cord injury Spinal Cord, 2010.PMID 20498664
  10. [10]Yokose M, Sangawa M, Shiomi H, et al. Initial Dose of Intravenous Atropine for Patients With Symptomatic Bradycardia: A Scoping Review Circulation Reports, 2025.PMID 41216404
  11. [11]Evans CH, Duby JJ, Berry AJ, et al. Enteral albuterol decreases the need for chronotropic agents in patients with cervical spinal cord injury-induced bradycardia Journal of Trauma and Acute Care Surgery, 2014.PMID 24458037
  12. [12]Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study New England Journal of Medicine, 1990.PMID 2278545
  13. [13]Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial JAMA, 1997.PMID 9168289
  14. [14]Fehlings MG, Vaccaro A, Wilson JR, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) PLoS ONE, 2012.PMID 22384132
  15. [15]Krueckel J, Kerschbaum M, Alt V, et al. Clinical Recommendations for the Acute Care of Patients With Traumatic Spinal Cord Injury Deutsches Arzteblatt International, 2025.PMID 40956680
  16. [16]Galeiras Vázquez R, Ferreiro Velasco ME, Mourelo Fariña M, et al. Update on traumatic acute spinal cord injury. Part 1 Medicina Intensiva, 2017.PMID 28161028
  17. [17]Evaniew N, Davies B, Farahbakhsh F, et al. Interventions to Optimize Spinal Cord Perfusion in Patients With Acute Traumatic Spinal Cord Injury: An Updated Systematic Review Global Spine Journal, 2024.PMID 38526931
  18. [18]Ko HY Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock Korean Journal of Neurotrauma, 2018.PMID 30402418

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