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ICU TopicsResuscitation & shock

ICU · Resuscitation & shock

Hypovolaemic & Haemorrhagic Shock

Also known as Haemorrhagic shock · Hypovolaemic shock · Damage control resuscitation · Massive transfusion protocol · Damage control surgery · Trauma-induced coagulopathy · Lethal triad · Permissive hypotension · ATLS shock classification · Fluid responsiveness

Hypovolaemic and haemorrhagic shock — blood loss reduces preload and cardiac output. The four ATLS classes guide recognition (a classic teaching tool with known limitations), progressing from compensated to decompensated shock. Hypotension is a LATE sign — the body compensates with tachycardia and vasoconstriction before blood pressure falls, and many bleeding patients are normotensive. Modern management is damage control resuscitation: permissive hypotension until bleeding is controlled (except TBI — higher blood-pressure thresholds apply), balanced blood-product resuscitation, damage control surgery, and early TXA. Lactate and base deficit are the recommended markers of bleeding and shock.

high26 referencesUpdated 19 Aug 202617 min readSource-verified · Oct 2026

Checked against its sources on 2 Oct 2026

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Hypovolaemic and haemorrhagic shock is blood loss reducing preload and cardiac output — haemorrhage is the leading cause of preventable deaths in trauma patients. The four ATLS classes (from class I compensated through to class IV decompensated) guide recognition, but hypotension is a late sign: in the ATLS classification blood pressure is unchanged until class III — and registry data show most real bleeding patients do not fit the textbook vital-sign patterns. Modern management is damage control resuscitation — permissive hypotension until bleeding is controlled, balanced blood-product transfusion, TXA as early as possible (within 3 hours of injury), and damage control surgery. Never use permissive hypotension in TBI.[1][10][5]

Meet the patient

A 32-year-old man arrives 50 minutes after a motorcycle crash. He is anxious and confused. HR 128, BP 96/64 (pulse pressure 32), lactate 5.2, urine output 15 mL in the first hour. FAST is positive in the abdomen.[19]

His blood pressure looks almost normal — and that is the trap. The narrowed pulse pressure (96 minus 64 is 32), the tachycardia, the confusion and the lactate all say he is in severe, decompensating haemorrhagic shock. In the ATLS classification blood pressure stays unchanged until class III, so his near-normal reading does not reassure.[7][10][11]

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References26ShowHide
  1. [1]Kalkwarf KJ, Cotton BA Resuscitation for Hypovolemic Shock Surg Clin North Am, 2017.PMID 29132511
  2. [2]Pohlman TH, Walsh M, Aversa J, et al. Damage control resuscitation Blood Rev, 2015.PMID 25631636
  3. [3]Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries N Engl J Med, 1994.PMID 7935634
  4. [4]Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial JAMA, 2015.PMID 25647203
  5. [5]Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet, 2010.PMID 20554319
  6. [6]Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial Lancet, 2011.PMID 21439633
  7. [7]Spahn DR, Bouillon B, Cerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition Crit Care, 2019.PMID 30917843
  8. [8]Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis J Trauma, 2008.PMID 18469643
  9. [9]Cannon JW, Khan MA, Raja AS, et al. Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma J Trauma Acute Care Surg, 2017.PMID 28225743
  10. [10]Mutschler M, Nienaber U, Brockamp T, et al. A critical reappraisal of the ATLS classification of hypovolaemic shock: does it really reflect clinical reality? Resuscitation, 2013.PMID 22835498
  11. [11]Mutschler M, Paffrath T, Wölfl C, et al. The ATLS classification of hypovolaemic shock: a well established teaching tool on the edge? Injury, 2014.PMID 25284231
  12. [12]Tran A, Yates J, Lau A, et al. Permissive hypotension versus conventional resuscitation strategies in adult trauma patients with hemorrhagic shock: A systematic review and meta-analysis of randomized controlled trials J Trauma Acute Care Surg, 2018.PMID 29370058
  13. [13]Moore HB, Tessmer MT, Moore EE, et al. Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock J Trauma Acute Care Surg, 2020.PMID 32317575
  14. [14]Chanthima P, Yuwapattanawong K, Thamjamrassri T, et al. Association Between Ionized Calcium Concentrations During Hemostatic Transfusion and Calcium Treatment With Mortality in Major Trauma Anesth Analg, 2021.PMID 33646983
  15. [15]Winearls J, Reade MC, McQuilten Z, et al. Fibrinogen in traumatic haemorrhage Curr Opin Anaesthesiol, 2021.PMID 34091461
  16. [16]Jansen TC, van Bommel J, Schoonderbeek FJ, et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial Am J Respir Crit Care Med, 2010.PMID 20463176
  17. [17]Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med, 2001.PMID 11794169
  18. [18]Marik PE, Baram M, Vahid B Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares Chest, 2008.PMID 18628220
  19. [19]Galvagno SM Jr, Nahmias JT, Young DA Advanced Trauma Life Support Update 2019: Management and Applications for Adults and Special Populations Anesthesiol Clin, 2019.PMID 30711226
  20. [20]Balog Virág K, Csikós P, Raska A, et al. Cell-dependent antithrombotic effect of tranexamic acid Front Immunol, 2026.PMID 42273679
  21. [21]Shibahashi K, Sugiyama K, Okura Y, et al. Defining Hypotension in Patients with Severe Traumatic Brain Injury World Neurosurg, 2018.PMID 30189306
  22. [22]Scheingraber S, Rehm M, Sehmisch C, Finsterer U Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery Anesthesiology, 1999.PMID 10319771
  23. [23]Semler MW, Self WH, Wanderer JP, et al. Balanced Crystalloids versus Saline in Critically Ill Adults N Engl J Med, 2018.PMID 29485925
  24. [24]Hernández G, Ospina-Tascón GA, Damiani LP, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial JAMA, 2019.PMID 30772908
  25. [25]Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection N Engl J Med, 2011.PMID 21615299
  26. [26]Parra MW, Ordoñez CA, Mejia D, et al. Damage control approach to refractory neurogenic shock: a new proposal to a well-established algorithm. Colomb Med (Cali), 2021.PMID 34908624

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