Endpoints of Resuscitation — Lactate, ScvO2, Mottling, Urine, Capillary Refill

Also known as Resuscitation endpoints · Adequacy of resuscitation · Lactate clearance · ScvO2 · Central venous oxygen saturation · Mottling score · Capillary refill time · ANDROMEDA-SHOCK · Goal-directed therapy · Pcv-aCO2 gap · Venous-to-arterial CO2 gap · Base deficit · De-resuscitation · Fluid overload · Sublingual microcirculation · NIRS StO2 · ROSE fluid framework

Resuscitation endpoints span three tiers used together rather than in isolation: macro-haemodynamic endpoints such as MAP and urine output, metabolic endpoints such as lactate clearance and ScvO2, and peripheral perfusion endpoints such as capillary refill time, mottling score, and skin temperature.

high23 referencesUpdated 26 July 202619 min readSource-verified · Oct 2026

Checked against its sources on 2 Oct 2026

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8 MCQs

Meet the patient

A 55-year-old man in septic shock from a urinary focus has received initial crystalloid (the Surviving Sepsis Campaign suggests at least 30 mL/kg within the first 3 hours) and is now on noradrenaline at 0.3 mcg/kg/min. His MAP is 70, lactate 3.2 (was 5.1), capillary refill 6 s, mottling around both knees, ScvO2 65 per cent. The registrar asks whether he is adequately resuscitated.^[7]

The MAP looks fine; the lactate is coming down. But the periphery tells a different story. The answer to "have I resuscitated enough?" is never a single number — it is three tiers of evidence read together, and the bedside finger press you can do in five seconds carries as much weight as the arterial gas.^[3]

References23Show

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