Skip to main content
MedVellum
QuestionsVideosPricing

MedVellum

Fellowship exam preparation across every specialty: source-verified topics, questions in every format, and videos.

Product

  • Specialties
  • Questions
  • Videos
  • Exam tools
  • Pricing

Verification & policy

  • Verified register
  • Editorial policy
  • Privacy
  • Terms

Account

  • Sign in
  • Create account
  • Dashboard
  • Account & billing

© 2026 MedVellum. For education only — not a substitute for clinical judgement.

llms.txtPsychiatry LLM catalogSitemap

ICU TopicsICU-acquired infection

ICU · ICU-acquired infection

ICU-Acquired Infection — VAP, CRBSI and CLABSI

Also known as Ventilator-associated pneumonia · VAP · Catheter-related bloodstream infection · CRBSI · Central line infection · Nosocomial infection · Catheter-associated UTI

The ICU-acquired infections are the complications of the critical care itself — the ventilator-associated pneumonia (the VAP), the catheter-related bloodstream infection (the CRBSI), the catheter-associated UTI, and the Clostridioides difficile. Each increases the mortality, the length of stay, and the cost, and each is largely PREVENTABLE through the bundles. This topic builds the examiner's framework on the VAP (the diagnosis, the prevention bundle, the short-course antibiotics), the CRBSI (the prevention, the diagnosis, the catheter removal), and the general principles of the infection prevention in the ICU.

high20 referencesUpdated 19 Aug 202628 min readVerification in progress

Practise this topic

  • 8 MCQs

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDICESICMSociety_CCM
On this page
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDICESICMSociety_CCM

Meet the patient

A 65-year-old man has been ventilated for six days for severe ARDS. The nurse calls you at 3am: new fever, purulent secretions, rising FiO2 requirement, and a new infiltrate in the right lower lobe. His central line has been in for eight days. The question is not 'is this VAP or CRBSI?' — it is 'what in my own practice let this happen, and how do I stop the next one?'.[1]

Every ICU-acquired infection is a device complication we inflict. The ventilator, the central line, the urinary catheter — each is a highway for bacteria into a sterile site, and day bundle is not done is day line infects. Prevention beats treatment, and the bundle done every time beats the clever antibiotic.[1]

ICU Fellowship (CICM) Pro

Continue reading

You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the ICU Fellowship (CICM) fellowship library.

Sign in to continueSee pricing
References20ShowHide
  1. [1]Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU N Engl J Med, 2006.PMID 17192537
  2. [2]O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the prevention of intravascular catheter-related infections Clin Infect Dis, 2011.PMID 21460264
  3. [3]Klompas M, Branson R, Eichenwald EC, et al. Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update Infect Control Hosp Epidemiol, 2014.PMID 25026607
  4. [4]Kalil AC, Metersky ML, Klompas M, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society Clin Infect Dis, 2016.PMID 27418577
  5. [5]Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial JAMA, 2003.PMID 14625336
  6. [6]McDonald LC, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) Clin Infect Dis, 2018.PMID 29462280
  7. [7]Climo MW, Yokoe DS, Warren DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection N Engl J Med, 2013.PMID 23388005
  8. [8]Schuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections Cochrane Database Syst Rev, 2017.PMID 29025194
  9. [9]Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 JAMA Surg, 2017.PMID 28467526
  10. [10]Johnson S, Lavergne V, Skinner AM, et al. Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults Clin Infect Dis, 2021.PMID 34164674
  11. [11]Louie TJ, Miller MA, Mullane KM, et al. Fidaxomicin versus vancomycin for Clostridium difficile infection N Engl J Med, 2011.PMID 21288078
  12. [12]Wilcox MH, Gerding DN, Poxton IR, et al. Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection N Engl J Med, 2017.PMID 28121498
  13. [13]Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis Am J Gastroenterol, 2012.PMID 22710578
  14. [14]Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America Clin Infect Dis, 2009.PMID 19489710
  15. [15]Mo Y, Booraphun S, Li AY, et al. Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial Lancet Respir Med, 2024.PMID 38272050
  16. [16]Klompas M, Branson R, Cawcutt K, et al. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update Infect Control Hosp Epidemiol, 2022.PMID 35589091
  17. [17]Culver DH, Horan TC, Gaynes RP, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance System Am J Med, 1991.PMID 1656747
  18. [18]Devlin JW, Skrobik Y, Gélinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Crit Care Med, 2018.PMID 30113379
  19. [19]Zhao T, Wu X, Zhang Q, et al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia Cochrane Database Syst Rev, 2020.PMID 33368159
  20. [20]Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Lancet, 2008.PMID 18191684

Test yourself

Practise what you just read

  • 8 MCQs
ICU Fellowship (CICM) Pro

$29/ monthor $279 / year

The complete ICU Fellowship (CICM) library, every exam format, one subscription.

  • Complete library for one chosen specialty
  • Timed MCQ mock exams and spaced review
  • Clinical cases & cross-table vivas
See pricingSign in
PreviousTracheostomy in ICU: timing, technique, and weaningProceduralNextICU-Acquired Infection Prevention Bundle — Comprehensiveicu-acquired-infection