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ICU TopicsAirway management

ICU · Airway management

Airway Management

Also known as Endotracheal intubation · Rapid sequence induction (RSI) · Difficult airway · Front-of-neck access (FONA)

Tracheal intubation in the critically ill patient is one of the highest-risk procedures in intensive care: the INTUBE study of nearly 3000 intubations across 29 countries found that 45.2% of patients suffered a major adverse peri-intubation event, led by cardiovascular instability. Unlike the fasted, monitored anaesthetic patient, the ICU patient is hypoxaemic, hypotensive, often shocked, and frequently difficult — so the airway is managed not as an isolated technical act but as a physiological resuscitation around a planned procedure. This topic covers airway assessment (MACOCHA, LEMON), the physiology of preoxygenation and desaturation, rapid sequence induction and its pharmacology, the Difficult Airway Society 2015 algorithm (Plans A to D), rescue oxygenation with supraglottic airways and face-mask ventilation, the cannot-intubate-cannot-oxygenate emergency and front-of-neck access, cardiovascular collapse and its prevention, capnographic monitoring, and extubation — built on the verified landmark trials and the DAS/NAP4 evidence.

high22 referencesUpdated 20 Aug 202629 min readVerification in progress

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Red flags

  • Peri-intubation cardiovascular collapse is the commonest major complication (42.6% in INTUBE) and the most lethal — resuscitate first: correct hypovolaemia, start or increase vasopressors, and reduce or avoid the induction dose before you push the induction agent. A patient intubated in uncorrected shock arrests on the syringe
  • A low preoxygenation reserve means rapid desaturation — the critically ill patient desaturates within one or two minutes, not the eight minutes of a fasted healthy adult. Preoxygenate to an SpO2 of 100% where possible and use apnoeic oxygenation; never begin laryngoscopy on a patient who is already hypoxaemic
  • Capnography is mandatory — the misplaced tube remains a leading cause of airway death (NAP4). Confirm tracheal placement with a sustained waveform of exhaled carbon dioxide on every intubation, not by chest movement or condensation alone
  • A MACOCHA score of 3 or above predicts difficult intubation (validation NPV 98%) — assess every ICU patient before induction, prepare the difficult-airway kit, and call senior help early rather than after the first attempt fails
  • Cannot intubate, cannot oxygenate is a time-critical emergency — if face-mask ventilation and a supraglottic airway both fail and oxygenation is being lost, perform emergency front-of-neck access (scalpel-bougie cricothyroidotomy) without delay; repeated fruitless attempts kill the patient
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Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDICESICMSociety_CCM

Red flags

  • Peri-intubation cardiovascular collapse is the commonest major complication (42.6% in INTUBE) and the most lethal — resuscitate first: correct hypovolaemia, start or increase vasopressors, and reduce or avoid the induction dose before you push the induction agent. A patient intubated in uncorrected shock arrests on the syringe
  • A low preoxygenation reserve means rapid desaturation — the critically ill patient desaturates within one or two minutes, not the eight minutes of a fasted healthy adult. Preoxygenate to an SpO2 of 100% where possible and use apnoeic oxygenation; never begin laryngoscopy on a patient who is already hypoxaemic
  • Capnography is mandatory — the misplaced tube remains a leading cause of airway death (NAP4). Confirm tracheal placement with a sustained waveform of exhaled carbon dioxide on every intubation, not by chest movement or condensation alone
  • A MACOCHA score of 3 or above predicts difficult intubation (validation NPV 98%) — assess every ICU patient before induction, prepare the difficult-airway kit, and call senior help early rather than after the first attempt fails
  • Cannot intubate, cannot oxygenate is a time-critical emergency — if face-mask ventilation and a supraglottic airway both fail and oxygenation is being lost, perform emergency front-of-neck access (scalpel-bougie cricothyroidotomy) without delay; repeated fruitless attempts kill the patient
The one-line answer

ICU airway management is a resuscitation that happens to include a procedure, not a procedure bolted onto a stable patient. The critically ill patient desaturates in one to two minutes and collapses at induction, so the marks are in preparation, preoxygenation and cardiovascular resuscitation — predict difficulty with MACOCHA and LEMON, preoxygenate to denitrogenate, induce with a reduced dose and paralyse, confirm with waveform capnography, and brief Plan A, Plan B (supraglottic airway) and Plan C (scalpel-bougie front-of-neck access) before induction. INTUBE found nearly half of ICU intubations had a major adverse event.[1][2]

Meet the patient

A 66-year-old woman with severe pneumonia and septic shock — SpO2 89 percent on 15 L/min, MAP 58 on noradrenaline, GCS 12 and tiring — needs intubating. She is obese with a short neck and an overbite. Every physiological reserve is gone before you reach for the laryngoscope.[2]

The question the examiner is really asking is not "can you pass the tube" but did you resuscitate, preoxygenate and predict difficulty before you induced?[1]

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References22ShowHide
  1. [1]Frerk C, Mitchell VS, McNarry AF, Mendonca C, et al. Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults Br J Anaesth, 2015.PMID 26556848
  2. [2]Russotto V, Myatra SN, Laffey JG, et al. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries JAMA, 2021.PMID 33755076
  3. [3]De Jong A, Molinari N, Terzi N, et al. Early identification of patients at risk for difficult intubation in the intensive care unit: development and validation of the MACOCHA score in a multicenter cohort study Am J Respir Crit Care Med, 2013.PMID 23348979
  4. [4]Tran DT, Newton EK, Mount VA, Lee JS, Wells GA, Perry JJ. Rocuronium versus succinylcholine for rapid sequence induction intubation Cochrane Database Syst Rev, 2015.PMID 26512948
  5. [5]Guitton C, Ehrmann S, Volteau C, et al. Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial Intensive Care Med, 2019.PMID 30666367
  6. [6]Driver BE, Prekker ME, Klein LR, et al. Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial JAMA, 2018.PMID 29800096
  7. [7]Patel A, Nouraei SAR. Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): a physiological method of increasing apnoea time in patients with difficult airways Anaesthesia, 2015.PMID 25388828
  8. [8]Lascarrou JB, Boisrame-Helms J, Bailly A, et al. Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial JAMA, 2017.PMID 28118659
  9. [9]Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial Lancet, 2009.PMID 19573904
  10. [10]Chrimes N. The Vortex: a universal 'high-acuity implementation tool' for emergency airway management Br J Anaesth, 2016.PMID 27440673
  11. [11]Higgs A, McGrath BA, Goddard C, et al. Guidelines for the management of tracheal intubation in critically ill adults Br J Anaesth, 2018.PMID 29406182
  12. [12]Blanié A, Ract C, Leblanc PE, et al. The limits of succinylcholine for critically ill patients Anesth Analg, 2012.PMID 22763904
  13. [13]Naguib M, Brewer L, LaPierre C, et al. The myth of rescue reversal in cannot-intubate, cannot-ventilate scenarios Anesth Analg, 2016.PMID 27140684
  14. [14]Kadoi Y, Hoshi H, Nishida A, et al. Comparison of recovery times from rocuronium-induced muscle relaxation after reversal with three different doses of sugammadex and succinylcholine during electroconvulsive therapy J Anesth, 2011.PMID 21947754
  15. [15]Soro Domingo M, Belda Nácher FJ, Aguilar Aguilar G, et al. [Preoxygenation for anesthesia]. Rev Esp Anestesiol Reanim, 2004.PMID 15303533
  16. [16]De Jong A, Futier E, Millot A, et al. How to preoxygenate in operative room: healthy subjects and situations at risk Ann Fr Anesth Reanim, 2014.PMID 25168301
  17. [17]Taha SK, El-Khatib MF, Siddik-Sayyid SM, et al. Preoxygenation by 8 deep breaths in 60 seconds using the Mapleson A (Magill), the circle system, or the Mapleson D system J Clin Anesth, 2009.PMID 20122589
  18. [18]Bucher J, Koyfman A Intubation of the neurologically injured patient J Emerg Med, 2015.PMID 26416129
  19. [19]Ferguson I, et al. Does the addition of fentanyl to ketamine improve haemodynamics, intubating conditions or mortality in emergency department intubation: a systematic review Acta Anaesthesiol Scand, 2019.PMID 30644096
  20. [20]Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med, 2000.PMID 10793162
  21. [21]Jaber S, Jung B, Corne P, et al. An intervention to decrease complications related to endotracheal intubation in the intensive care unit: a prospective, multiple-center study Intensive Care Med, 2010.PMID 19921148
  22. [22]Sorbello M, Paternò DS, Zdravkovic I. Pharmacological approach to rapid sequence induction/intubation: a contemporary perspective Curr Opin Anaesthesiol, 2025.PMID 40493782

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