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ICU TopicsAirway management

ICU · Airway management

Awake Fibre-Optic Intubation

Also known as Awake fibre-optic intubation · AFOI · Awake intubation · Fibre-optic intubation · Topical airway anaesthesia · Spray-as-you-go · Cooperative sedation · Dexmedetomidine for intubation · Local anaesthetic airway · Superior laryngeal nerve block · Glossopharyngeal nerve block · Anticipated difficult airway

Awake fibre-optic intubation (AFOI) is the safest approach to the anticipated difficult airway when the patient can cooperate and maintain oxygenation: topicalise the upper airway with local anaesthetic, sedate lightly so the patient stays breathing with airway reflexes preserved, navigate a flexible scope through the cords on inspiration, and railroad an endotracheal tube. The principle is that the patient never loses their airway. Indications are a predicted difficult airway (prior difficulty, cervical instability, limited mouth opening, distorted anatomy, head-and-neck mass, obesity, risk of 'can't intubate, can't ventilate'); contraindications are inability to cooperate, inability to tolerate apnoea, complete upper-airway obstruction, an airway flooded with blood or secretions, and local-anaesthetic allergy. Technique: topicalisation with lidocaine 1–4% (spray, nebulised, gargle, paste, or spray-as-you-go), optional nerve blocks (superior laryngeal and glossopharyngeal), cooperative sedation with dexmedetomidine or remifentanil target-controlled infusion, scope handling, and railroading of the ETT over the scope. Complications include laryngospasm, local-anaesthetic systemic toxicity (LAST), and airway trauma.

medium32 referencesUpdated 19 Aug 202626 min readVerification in progress

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Overview & definition

Awake fibre-optic intubation (AFOI) is intubation of a conscious, spontaneously breathing patient whose upper airway has been topicalised with local anaesthetic, lightly sedated, using a flexible fibre-optic scope to guide the tube through the cords. Its great advantage is that the patient never loses their airway — they keep breathing and maintain their own airway tone throughout — which makes it the safest approach to the anticipated difficult airway.[1][12]

It is the opposite of rapid sequence intubation: instead of rendering the patient unconscious and apnoeic (and risking the loss of the airway in a known-difficult patient), AFOI keeps the patient cooperative and oxygenating while the airway is secured under vision.[1]

Key terminology for the viva. 'Awake' is a misnomer — the patient is cooperatively sedated, not alert. 'Fibre-optic' strictly refers to the flexible fibrescope, but the term now embraces flexible video-scopes (single-use and reusable) that are the modern standard. The unifying principle is a flexible endoscope, navigated under vision through a topicalised upper airway in a breathing patient, and an endotracheal tube railroaded over it.[1][6]

The one-line exam answer

Awake fibre-optic intubation secures the anticipated difficult airway without ever losing it — it remains the gold standard in the expected difficult airway because, applied correctly, it never compromises the patient's respiration before the airway is secured. Topicalise the upper airway with lidocaine (maximum quoted 9 mg/kg lean body weight; sum every route and dose), sedate cooperatively — dexmedetomidine has the most complete pharmacological profile with minimal respiratory depression — navigate the scope through the cords on inspiration, and railroad the tube. It is the safest plan when difficulty is predicted and the patient can cooperate and oxygenate — and the wrong plan when they cannot.[12][13]

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References32ShowHide
  1. [1]Higgs A, McGrath BA, Goddard C, et al. Guidelines for the management of tracheal intubation in critically ill adults Br J Anaesth, 2018.PMID 29406182
  2. [2]Apfelbaum JL, Hagberg CA, Connis RT, et al. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway Anesthesiology, 2022.PMID 34762729
  3. [3]Cook TM, Woodall N, Frerk C; Fourth National Audit Project Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 1: anaesthesia Br J Anaesth, 2011.PMID 21447488
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  5. [5]Mushambi MC, Athanassoglou V, Kinsella SM, et al. Anticipated difficult airway during obstetric general anaesthesia: narrative literature review and management recommendations Anaesthesia, 2020.PMID 32144770
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  17. [17]Kumar MP, Patro M, Panigrahy S, et al. Comparison between Intravenous Dexmedetomidine and Spray as you Go with 4% Lignocaine Versus Intravenous Fentanyl and Transtracheal Injection of 4% Lignocaine for Awake Nasotracheal Intubation with Flexible Vedioscope - A Randomized Single-Blind Prospective Study Anesth Essays Res, 2021.PMID 35281363
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  25. [25]O'Connor J, Wilson SS Intravenous Lipid Emulsion for Management of Systemic Toxic Effects of Drugs AACN Adv Crit Care, 2016.PMID 27959295
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