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ICU TopicsRespiratory / monitoring

ICU · Respiratory / monitoring

Patient–Ventilator Asynchrony

Also known as Patient-ventilator asynchrony · Asynchrony · Ineffective triggering · Double triggering · Breath stacking · Auto-triggering · Flow starvation · Reverse triggering · Fighting the ventilator · Asynchrony index

Patient-ventilator asynchrony is a mismatch between the patient's neural respiratory drive and the ventilator's delivered breaths, detectable on the waveforms. It is common and associated with longer ventilation and higher mortality. The types fall by the phase of the breath: trigger asynchrony (ineffective triggering, auto-triggering, double triggering/breath stacking), flow asynchrony (starvation, excess), and cycle asynchrony (premature or delayed cycling). An asynchrony index over 10 per cent is significant. Management is to read the waveforms, identify the type, and fix the cause — sedation, the trigger sensitivity, the flow and inspiratory time, and a cycling-off criterion — with NAVA or PAV for refractory cases.

high11 referencesUpdated 26 July 20263 min readVerification in progress

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Patient–ventilator asynchrony is a timing or demand mismatch: identify whether trigger, flow, or cycling is wrong on the waveforms, correct the mechanical cause, and use sedation only when it treats a real patient problem. An asynchrony index above 10 percent is conventionally significant.[1][2][3]

Meet the patient

An intubated patient is labelled agitated and receives more sedation. The pressure trace remains concave, two breaths stack without expiration, and the delivered tidal volume doubles. The patient was not asking for sleep; the respiratory drive was asking for flow and inspiratory time.[1][2]

The mantra: read the breath before treating the behaviour.[1]

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References11ShowHide
  1. [1]Hodzic-Santor B, Telias I, et al. Asynchrony: Clinical Relevance, Detection, and Resolution Respir Care, 2025.PMID 40971310
  2. [2]Thille AW, Rodriguez P, Cabello B, et al. Patient-ventilator asynchrony during assisted mechanical ventilation Intensive Care Med, 2006.PMID 16896854
  3. [3]Blanch L, Villagra A, Sales B, et al. Asynchronies during mechanical ventilation are associated with mortality Intensive Care Med, 2015.PMID 25693449
  4. [4]de Wit M, Miller KB, Green DA, et al. Ineffective triggering predicts increased duration of mechanical ventilation Crit Care Med, 2009.PMID 19886000
  5. [5]de Wit M, Pedram S, Best AM, et al. Observational study of patient-ventilator asynchrony and relationship to sedation level J Crit Care, 2009.PMID 19272542
  6. [6]Akoumianaki E, Lyazidi A, Rey N, et al. Mechanical ventilation-induced reverse-triggered breaths: a frequently unrecognized form of neuromechanical coupling Chest, 2013.PMID 23187649
  7. [7]Xirouchaki N, Kondili E, Vaporidi K, et al. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support Intensive Care Med, 2008.PMID 18607562
  8. [8]Bosma KJ, Read BA, Bahrgard Nikoo MJ, et al. A Pilot Randomized Trial Comparing Weaning From Mechanical Ventilation on Pressure Support Versus Proportional Assist Ventilation Crit Care Med, 2016.PMID 26807682
  9. [9]Carteaux G, Lyazidi A, Cordoba-Izquierdo A, et al. Patient-ventilator asynchrony during noninvasive ventilation: a bench and clinical study Chest, 2012.PMID 22406958
  10. [10]Mellado Artigas R, Damiani LF, Piraino T, et al. Reverse Triggering Dyssynchrony 24 h after Initiation of Mechanical Ventilation Anesthesiology, 2021.PMID 33662121
  11. [11]Pham T, Montanya J, Telias I, et al. Automated detection and quantification of reverse triggering effort under mechanical ventilation Crit Care, 2021.PMID 33588912

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