Skip to main content
MedVellum
QuestionsVideosPricing

MedVellum

Fellowship exam preparation across every specialty: source-verified topics, questions in every format, and videos.

Product

  • Specialties
  • Questions
  • Videos
  • Exam tools
  • Pricing

Verification & policy

  • Verified register
  • Editorial policy
  • Privacy
  • Terms

Account

  • Sign in
  • Create account
  • Dashboard
  • Account & billing

© 2026 MedVellum. For education only — not a substitute for clinical judgement.

llms.txtPsychiatry LLM catalogSitemap

ICU TopicsObs/Gynae

ICU · Obs/Gynae

Obstetric emergencies in the ICU

Also known as Pre-eclampsia and eclampsia · HELLP syndrome · Peripartum cardiomyopathy · Amniotic fluid embolism · Sepsis in pregnancy · Postpartum haemorrhage in ICU · Venous thromboembolism in pregnancy · Maternal critical care · Massive obstetric haemorrhage · Pregnancy physiology and ICU implications

Obstetric ICU admissions are rare but high-stakes. Pre-eclampsia/eclampsia: magnesium sulphate for seizure prophylaxis and treatment (4 g IV load, 1-2 g/h; beats diazepam and phenytoin), antihypertensive therapy for severe-range BP (over 160/110), delivery definitive. HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low Platelets): usually preterm, malaise and right upper quadrant pain in 90 percent, hypertension may be absent. Peripartum cardiomyopathy: heart failure with LVEF under 45 percent, last month of pregnancy to 5 months postpartum — treat with pregnancy-safe HF therapy (diuretics, beta-blockers, hydralazine/nitrates, digoxin) plus bromocriptine. Amniotic fluid embolism: sudden cardiovascular collapse plus coagulopathy — high-quality CPR, early echo for right ventricular failure, 1:1:1 haemostatic resuscitation, VA-ECMO for the refractory. Physiological changes of pregnancy alter drug dosing, ventilation, and fluid management.

high39 referencesUpdated 17 Aug 202615 min readSource-verified · Sept 2026

Checked against its sources on 1 Sept 2026

Practise this topic

  • 8 MCQs

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Eclampsia: magnesium sulphate FIRST (seizures), THEN BP control. Magnesium prevents and treats seizures
  • HELLP with right upper quadrant pain (90 percent of cases): check platelets and liver enzymes whatever the blood pressure
  • Amniotic fluid embolism: sudden cardiovascular collapse + coagulopathy during labour or delivery — catastrophic
  • Pregnant patients desaturate rapidly: reduced functional reserve from a lower FRC — pre-oxygenate 3 minutes before any intubation
On this page
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Eclampsia: magnesium sulphate FIRST (seizures), THEN BP control. Magnesium prevents and treats seizures
  • HELLP with right upper quadrant pain (90 percent of cases): check platelets and liver enzymes whatever the blood pressure
  • Amniotic fluid embolism: sudden cardiovascular collapse + coagulopathy during labour or delivery — catastrophic
  • Pregnant patients desaturate rapidly: reduced functional reserve from a lower FRC — pre-oxygenate 3 minutes before any intubation
The one-line answer

Obstetric ICU is rare, young, and high-stakes — and almost every emergency resolves to the same three moves: stop the convulsion with magnesium, treat the severe-range blood pressure, and deliver. Pre-eclampsia and eclampsia dominate: magnesium sulphate halves and treats the seizures (it beat diazepam and phenytoin head-to-head), over 160/110 defines severe disease, delivery is the cure. HELLP announces itself with epigastric pain and low platelets, peripartum cardiomyopathy fails the heart at term, and amniotic fluid embolism collapses the patient and the clotting cascade together. Above every drug sits one non-negotiable rule: a pregnant patient desaturates fast, and she must never lie flat on her back.[18][20][25][29]

Meet the patient

A 32-year-old woman at 36 weeks is admitted to ICU post-ictal, BP 172 over 114, proteinuria 3 plus, platelets 85, AST 95, LDH 650. She has just fitted in front of the midwife. The two questions that decide her next hour are the two that decide almost every obstetric emergency: is the airway and circulation safe? and what do I deliver, and when?[20]

Hold those two questions and the rest slots into place — magnesium first, severe-range blood pressure second, left-lateral tilt always, delivery definitive. Desaturation and aortocaval compression are the two physiology traps that quietly undermine the resuscitation while you reach for the next drug.[25][29]

ICU Fellowship (CICM) Pro

Continue reading

You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the ICU Fellowship (CICM) fellowship library.

Sign in to continueSee pricing
References39ShowHide
  1. [1]Plante LA, Pacheco LD, Louis JM SMFM Consult Series #47: Sepsis during pregnancy and the puerperium Am J Obstet Gynecol, 2019.PMID 30684460
  2. [2]Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA, 2016.PMID 26903338
  3. [3]Sibai BM The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol, 1990.PMID 2309811
  4. [4]Audibert F, Friedman SA, Frangieh AY, Sibai BM Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome Am J Obstet Gynecol, 1996.PMID 8765269
  5. [5]Rodriguez Ziccardi M, Siddique MS Peripartum Cardiomyopathy StatPearls, 2026.PMID 29489231
  6. [6]Sliwa K, Hilfiker-Kleiner D, Petrie MC, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy Eur J Heart Fail, 2010.PMID 20675664
  7. [7]Hilfiker-Kleiner D, Haghikia A, Berliner D, et al. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study Eur Heart J, 2017.PMID 28934837
  8. [8]Hilfiker-Kleiner D, Haghikia A, Masuko D, et al. Outcome of subsequent pregnancies in patients with a history of peripartum cardiomyopathy Eur J Heart Fail, 2017.PMID 28345302
  9. [9]Clark SL, Hankins GD, Dudley DA, et al. Amniotic fluid embolism: analysis of the national registry Am J Obstet Gynecol, 1995.PMID 7726251
  10. [10]Fitzpatrick KE, Tuffnell D, Kurinczuk JJ, Knight M Incidence, risk factors, management and outcomes of amniotic-fluid embolism: a population-based cohort and nested case-control study BJOG, 2016.PMID 25683758
  11. [11]Pacheco LD, Clark SL, Klassen M, Hankins GDV Amniotic fluid embolism: principles of early clinical management Am J Obstet Gynecol, 2020.PMID 31376394
  12. [12]Say L, Chou D, Gemmill A, et al. Global causes of maternal death: a WHO systematic analysis Lancet Glob Health, 2014.PMID 25103301
  13. [13]WOMAN Trial Collaborators Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial Lancet, 2017.PMID 28456509
  14. [14]Wormer KC, Jamil RT, Bryant SB Postpartum Hemorrhage StatPearls, 2026.PMID 29763164
  15. [15]Charbit B, Mandelbrot L, Samain E, et al. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage J Thromb Haemost, 2007.PMID 17087729
  16. [16]Balki M, Wong CA Refractory uterine atony: still a problem after all these years Int J Obstet Anesth, 2021.PMID 34391025
  17. [17]Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial Lancet, 2002.PMID 12057549
  18. [18]Collaborative Eclampsia Trial Group Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial Lancet, 1995.PMID 7769899
  19. [19]Lu JF, Nightingale CH Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles Clin Pharmacokinet, 2000.PMID 10803454
  20. [20]Tranquilli AL, Brown MA, Zeeman GG, Dekker G, Sibai BM The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP) Pregnancy Hypertens, 2013.PMID 26105740
  21. [21]von Dadelszen P, Payne B, Li J, et al. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model Lancet, 2011.PMID 21185591
  22. [22]Magee LA, von Dadelszen P, Rey E, et al. Less-tight versus tight control of hypertension in pregnancy N Engl J Med, 2015.PMID 25629739
  23. [23]Kinsella SM, Winton AL, Mushambi MC, et al. Failed tracheal intubation during obstetric general anaesthesia: a literature review Int J Obstet Anesth, 2015.PMID 26303751
  24. [24]Pillai A, Chikhani M, Hardman JG Apnoeic oxygenation in pregnancy: a modelling investigation Anaesthesia, 2016.PMID 27440389
  25. [25]Hsu N, Gaiser RR Awareness and Aortocaval Obstruction in Obstetric Anesthesia Anesthesiol Clin, 2017.PMID 28131116
  26. [26]Katz VL Perimortem cesarean delivery: its role in maternal mortality Semin Perinatol, 2012.PMID 22280869
  27. [27]Cheung KL, Lafayette RA Renal physiology of pregnancy Adv Chronic Kidney Dis, 2013.PMID 23928384
  28. [28]Melchiorre K, Sharma R, Khalil A, Thilaganathan B Maternal Cardiovascular Function in Normal Pregnancy: Evidence of Maladaptation to Chronic Volume Overload Hypertension, 2016.PMID 26962206
  29. [29]Ejikeme C, Nandakumar V, Gotur D Respiratory physiological changes in pregnancy Respir Med, 2025.PMID 40614834
  30. [30]Ginsberg JS, Brill-Edwards P, Burrows RF, et al. Venous thrombosis during pregnancy: leg and trimester of presentation Thromb Haemost, 1992.PMID 1519211
  31. [31]Heit JA, Kobbervig CE, James AH, et al. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study Ann Intern Med, 2005.PMID 16287790
  32. [32]Roberts D, Brown J, Medley N, Dalziel SR Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth Cochrane Database Syst Rev, 2017.PMID 28321847
  33. [33]Gyamfi-Bannerman C, Thom EA, Blackwell SC, et al. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery N Engl J Med, 2016.PMID 26842679
  34. [34]Sung S, Vadakekut ES Fetal Heart Rate Tracing: Assessment and Clinical Interpretation StatPearls, 2026.PMID 31536234
  35. [35]Tsamantioti ES, Hashmi MF Teratogenic Medications StatPearls, 2026.PMID 31971726
  36. [36]Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors N Engl J Med, 2006.PMID 16760444
  37. [37]Yurdakök M Fetal and neonatal effects of anticoagulants used in pregnancy: a review Turk J Pediatr, 2012.PMID 23094528
  38. [38]Zielinsky P, MagalhÃes GA, Zurita-Peralta J, et al. Improvement in fetal pulmonary hypertension and maturity after reversal of ductal constriction: prospective cohort study Ultrasound Obstet Gynecol, 2021.PMID 33502049
  39. [39]Douglas KA, Redman CW. Eclampsia in the United Kingdom BMJ, 1994.PMID 7819845

Test yourself

Practise what you just read

  • 8 MCQs
ICU Fellowship (CICM) Pro

$29/ monthor $279 / year

The complete ICU Fellowship (CICM) library, every exam format, one subscription.

  • Complete library for one chosen specialty
  • Timed MCQ mock exams and spaced review
  • Clinical cases & cross-table vivas
See pricingSign in
PreviousAcute severe community-acquired pneumonia: special populations — pregnancyObs/GynaeNextAcute Hepatic Encephalopathy — Comprehensive ICU Management (West Haven, Lactulose, Rifaximin, Cerebral Oedema, Nutrition)gi-nutrition