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ICU TopicsNeurocritical

ICU · Neurocritical

Acute stroke in ICU: ischaemic, haemorrhagic, and neurocritical care

Also known as Ischaemic stroke · Haemorrhagic stroke · Intracerebral haemorrhage · Thrombolysis · Thrombectomy · Stroke ICU management

Acute stroke ICU management. ISCHAEMIC (80%): thrombolysis (alteplase within 4.5h — NINDS, ECASS III), thrombectomy (within 6-24h for large vessel occlusion — DAWN, DEFUSE-3), antiplatelet (aspirin within 24h), prevent complications. HAEMORRHAGIC (20%): blood pressure control (SBP <140 — INTERACT2), reverse coagulopathy, surgery (evacuation for cerebellar 3cm or lobar with deterioration), ICP management. ICU principles: definitive airway control when consciousness and reflexes fail, supplemental oxygen for saturation below 94%, normocapnia, normoglycaemia (140–180 mg/dL range, avoiding hypoglycaemia), normothermia, blood pressure management (permissive hypertension for ischaemic, controlled for haemorrhagic), DVT prophylaxis, swallowing assessment before oral intake.

high38 referencesUpdated 26 July 202629 min readSource-verified · Oct 2026

Checked against its sources on 1 Oct 2026

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CICMFFICMEDIC

Red flags

  • Time is brain — alteplase within 4.5h, thrombectomy within 6-24h for large vessel occlusion
  • Permissive hypertension for ischaemic stroke (SBP ≤220 without thrombolysis, ≤185 with thrombolysis)
  • CONTROLLED hypotension for haemorrhagic stroke (SBP &lt;140 — INTERACT2)
  • Swallow assessment BEFORE any oral intake (dysphagia common — aspiration risk)
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Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Time is brain — alteplase within 4.5h, thrombectomy within 6-24h for large vessel occlusion
  • Permissive hypertension for ischaemic stroke (SBP ≤220 without thrombolysis, ≤185 with thrombolysis)
  • CONTROLLED hypotension for haemorrhagic stroke (SBP &lt;140 — INTERACT2)
  • Swallow assessment BEFORE any oral intake (dysphagia common — aspiration risk)
The one-line answer

Acute stroke in the ICU is one fork read off a non-contrast CT, then a blood-pressure direction. Ischaemic stroke (the majority) gets reperfusion — alteplase within 4.5 hours (NINDS, ECASS-III), thrombectomy for large-vessel occlusion out to 24 hours when perfusion imaging shows salvageable brain (DAWN, DEFUSE-3), aspirin, and permissive hypertension to defend the penumbra. Haemorrhagic stroke (about 20 percent) gets controlled blood-pressure lowering to systolic 130 to 140 (INTERACT2), immediate reversal of any anticoagulant, and surgery for the threatened cerebellar clot. Both share one ICU spine — normoxia, normocapnia, normoglycaemia, normothermia, DVT prophylaxis, and a swallow check before anything by mouth.[1]

Meet the patient

A 64-year-old man is brought to the emergency department at 7am, fifty minutes after his wife found him slumped in bed, unable to lift his right arm and speaking only jargon. Blood pressure 196/104, glucose 8.2 mmol/L, NIHSS 16, GCS 14. The CT scanner is warming before the cannula is in. The clock that matters now is the door-to-needle clock.[1]

Two questions decide his next hour, and they decide every acute stroke: is the CT bright or dark? (ischaemic versus haemorrhagic — the fork that reverses every target), and can I reperfuse in time? (the clock from onset to needle or groin puncture). Hold those two questions and the whole ICU plan slots into place behind them.[1]

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References38ShowHide
  1. [1]Powers WJ, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke, 2019.PMID 31662037
  2. [2]Nogueira RG, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct N Engl J Med, 2018.PMID 29129157
  3. [3]Albers GW, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging N Engl J Med, 2018.PMID 29364767
  4. [4]Anderson CS, et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage N Engl J Med, 2013.PMID 23713578
  5. [5]Hemphill JC, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke, 2015.PMID 26022637
  6. [6]Qureshi AI, et al. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage N Engl J Med, 2016.PMID 27276234
  7. [7]NINDS rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke N Engl J Med, 1995.PMID 7477192
  8. [8]Hacke W, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N Engl J Med, 2008.PMID 18815396
  9. [9]Berkhemer OA, et al. A randomized trial of intraarterial treatment for acute ischemic stroke N Engl J Med, 2015.PMID 25517348
  10. [10]Campbell BCV, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection N Engl J Med, 2015.PMID 25671797
  11. [11]Saver JL, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke N Engl J Med, 2015.PMID 25882376
  12. [12]Goyal M, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke N Engl J Med, 2015.PMID 25671798
  13. [13]Jovin TG, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke N Engl J Med, 2015.PMID 25882510
  14. [14]Thomalla G, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset N Engl J Med, 2018.PMID 29766770
  15. [15]Ma H, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke N Engl J Med, 2019.PMID 31067369
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  17. [17]Jüttler E, et al. Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke N Engl J Med, 2014.PMID 24645942
  18. [18]Mendelow AD, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial Lancet, 2013.PMID 23726393
  19. [19]Baharoglu MI, et al. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial Lancet, 2016.PMID 27178479
  20. [20]Sherman DG, et al. Prevention of venous thromboembolism, recurrent stroke, and other vascular events after acute ischemic stroke: the role of low-molecular-weight heparin and antiplatelet therapy J Stroke Cerebrovasc Dis, 2006.PMID 17904084
  21. [21]Ma L, et al. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial Lancet, 2023.PMID 37245517
  22. [22]Campbell BCV, et al. Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke N Engl J Med, 2018.PMID 29694815
  23. [23]AVERT Trial Collaboration. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial Lancet, 2015.PMID 25892679
  24. [24]Langezaal LCM, et al. Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion N Engl J Med, 2021.PMID 34010530
  25. [25]Amarenco P, et al. High-dose atorvastatin after stroke or transient ischemic attack N Engl J Med, 2006.PMID 16899775
  26. [26]EFFECTS Trial Collaboration. Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial Lancet Neurol, 2020.PMID 32702335
  27. [27]Jain AR, et al. Treatment of hypertension in acute ischemic stroke Curr Treat Options Neurol, 2009.PMID 19210914
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  29. [29]Menon BK, et al. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial Lancet, 2022.PMID 35779553
  30. [30]Lees KR, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials Lancet, 2010.PMID 20472172
  31. [31]Saver JL. Time is brain—quantified Stroke, 2006.PMID 16339467
  32. [32]Gray CS, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK) Lancet Neurol, 2007.PMID 17434094
  33. [33]International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke Lancet, 1997.PMID 9174558
  34. [34]Coutinho J, et al. Anticoagulation for cerebral venous sinus thrombosis Cochrane Database Syst Rev, 2011.PMID 21833941
  35. [35]Sherman DG, et al. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison Lancet, 2007.PMID 17448820
  36. [36]Jüttler E, Unterberg A, Woitzik J, et al. Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke N Engl J Med, 2014.PMID 24645942
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  38. [38]Rincon F, Mayer SA. Clinical review: Critical care management of spontaneous intracerebral hemorrhage Crit Care, 2008.PMID 19108704

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