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ICU TopicsNeurocritical care / vascular

ICU · Neurocritical care / vascular

Intracerebral Haemorrhage — ICH Score, BP Control & Surgery

Also known as Intracerebral haemorrhage · ICH · Intraparenchymal haemorrhage · Hypertensive haemorrhage · Amyloid angiopathy · ICH score · Haematoma expansion · Spot sign · INTERACT2 · STICH II

Intracerebral haemorrhage (ICH) is the bleeding into the brain parenchyma, most commonly from hypertension (the deep location — basal ganglia, thalamus, pons, cerebellum) or amyloid angiopathy (the lobar location in the elderly). The CT shows a hyperdense lesion. The ICH Score (the GCS, the age over 80, the infratentorial location, the volume over 30 mL, the intraventricular extension) predicts the 30-day mortality. The management: BP control to SBP 140 mmHg (the INTERACT2 trial — safe and improves the functional outcome; the IV labetalol or nicardipine), reverse the anticoagulation rapidly (the PCC for warfarin; the andexanet alfa for the DOAC; the idarucizumab for dabigatran), prevent the haematoma expansion (the spot sign on the CT angiogram predicts the expansion), and surgery (the cerebellar haemorrhage — the urgent evacuation; the supratentorial — the STICH II showed no routine benefit).

high23 referencesUpdated 26 July 202618 min readSource-verified · Oct 2026

Checked against its sources on 13 Oct 2026

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Intracerebral haemorrhage (ICH) is bleeding into the brain parenchyma. The deep location — putamen, thalamus, pons, cerebellum — points to hypertension; the lobar location in the elderly points to cerebral amyloid angiopathy. The CT shows a hyperdense lesion, and the ICH Score (GCS, age 80 or over, infratentorial origin, volume 30 mL or more, intraventricular extension) grades 30-day mortality.[5] Two modifiable factors dominate: BP to under SBP 140 mmHg within 1 hour (INTERACT2 shifted the ordinal mRS favourably; ATACH-2 found no extra benefit and more renal adverse events at 110 to 139; the INTERACT3 care bundle — SBP under 140, glucose, temperature and anticoagulation control — improved functional outcome)[1][2][18] and rapid anticoagulant reversal within 1 hour — 4F-PCC (30 IU/kg in INCH, superior to FFP for INR normalisation) for warfarin, idarucizumab 5 g IV for dabigatran, andexanet alfa for apixaban and rivaroxaban.[17][8][7] Surgery is routine only for the cerebellar haematoma with brainstem compression, hydrocephalus, deterioration, or a volume of 15 mL or more;[21] STICH, STICH II and MISTIE III are negative for routine supratentorial evacuation.[13][3][4]

Meet the patient

A 68-year-old hypertensive man on apixaban for atrial fibrillation arrives with sudden left-sided weakness, vomiting and a GCS of 10. The CT shows a 45 mL right putaminal haematoma with intraventricular blood and early midline shift; his SBP is 198 over 112.[1]

Two questions decide his next hour, and they decide every ICH: can I drop the SBP to 140 within an hour? and can I reverse the apixaban within an hour? Hold those two and the whole topic slots into place.[1]

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References23ShowHide
  1. [1]Anderson CS, Heeley E, Huang Y, et al Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage N Engl J Med, 2013.PMID 23713578
  2. [2]Qureshi AI, Palesch YY, Barsan WG, et al Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage N Engl J Med, 2016.PMID 27276234
  3. [3]Mendelow AD, Gregson BA, Rowan EN, et al Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial Lancet, 2013.PMID 23726393
  4. [4]Hanley DF, Thompson RE, Rosenblum M, et al Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial Lancet, 2019.PMID 30739747
  5. [5]Hemphill JC 3rd, Bonovich DC, Besmertis L, et al The ICH score: a simple, reliable grading scale for intracerebral hemorrhage Stroke, 2001.PMID 11283388
  6. [6]Wada R, Aviv RI, Fox AJ, et al CT angiography spot sign predicts hematoma expansion in acute intracerebral hemorrhage Stroke, 2007.PMID 17322083
  7. [7]Connolly SJ, Milling TJ Jr, Eikelboom JW, et al Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors N Engl J Med, 2016.PMID 27573206
  8. [8]Pollack CV Jr, Reilly PA, van Ryn J, et al Idarucizumab for Dabigatran Reversal - Full Cohort Analysis N Engl J Med, 2017.PMID 28693366
  9. [9]Mayer SA, Brun NC, Begtrup K, et al Recombinant activated factor VII for acute intracerebral hemorrhage N Engl J Med, 2005.PMID 15728810
  10. [10]Mayer SA, Brun NC, Begtrup K, et al Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage N Engl J Med, 2008.PMID 18480205
  11. [11]Hanley DF, Lane K, McBee N, et al Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial Lancet, 2017.PMID 28081952
  12. [12]Greenberg SM, Ziai WC, Cordonnier C, et al 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association Stroke, 2022.PMID 35579034
  13. [13]Mendelow AD, Gregson BA, Fernandes HM, et al Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial Lancet, 2005.PMID 15680453
  14. [14]Kothari RU, Brott T, Broderick JP, et al The ABCs of measuring intracerebral hemorrhage volumes Stroke, 1996.PMID 8711791
  15. [15]Hemphill JC 3rd, Farrant M, Neill TA Jr Prospective validation of the ICH Score for 12-month functional outcome Neurology, 2009.PMID 19726752
  16. [16]Baharoglu MI, Cordonnier C, Al-Shahi Salman R, et al. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial Lancet, 2016.PMID 27178479
  17. [17]Steiner T, Poli S, Griebe M, et al Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial Lancet Neurol, 2016.PMID 27302126
  18. [18]Ma L, Hu X, Song L, et al The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial Lancet, 2023.PMID 37245517
  19. [19]Hecht JP, Richards PG Continuous-Infusion Labetalol vs Nicardipine for Hypertension Management in Stroke Patients J Stroke Cerebrovasc Dis, 2018.PMID 29092768
  20. [20]Carney N, Totten AM, O'Reilly C, et al Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition Neurosurgery, 2017.PMID 27654000
  21. [21]Fischer MA, Rjepaj C, Steckbeck R, et al. Cerebellar Hemorrhage StatPearls, 2026.PMID 31082120
  22. [22]Hawkes MA, Rabinstein AA Anticoagulation for atrial fibrillation after intracranial hemorrhage: A systematic review Neurol Clin Pract, 2018.PMID 29517050
  23. [23]Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury Cochrane Database Syst Rev, 2020.PMID 31978260

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