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ICU TopicsNeurocritical care / monitoring

ICU · Neurocritical care / monitoring

ICP Monitoring & Waveforms

Also known as Intracranial pressure monitoring · ICP monitoring · ICP waveforms · Lundberg waves · Plateau waves · A-waves · P1 P2 P3 · External ventricular drain · EVD · Intraparenchymal pressure monitor · Codman · Cerebral perfusion pressure · CPP

Intracranial pressure (ICP) monitoring measures the pressure within the skull, guiding the management of raised ICP (target under 22 mmHg in TBI). The cerebral perfusion pressure (CPP = MAP minus ICP) is the key derived variable, with a target of 60-70 mmHg. The intraventricular catheter (external ventricular drain) is the gold standard (it measures, drains, and samples the CSF); the intraparenchymal microsensor (Codman) is accurate but cannot drain. The normal ICP waveform has three peaks: P1 (the arterial percussion), P2 (the tidal wave reflecting compliance — a P2 rising above P1 indicates a loss of compliance), and P3 (the venous dicrotic). The Lundberg A-wave (the plateau wave — a sudden sustained plateau rise from a vasodilatory cascade) indicates a critical loss of the intracranial compliance and requires an urgent treatment.

high18 referencesUpdated 26 July 202614 min readVerification in progress

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ICP monitoring guides the management of raised intracranial pressure (treat above 22 mmHg in TBI, per the Brain Trauma Foundation 4th edition). The derived variable that actually matters is the CPP = MAP − ICP, target 60 to 70 mmHg — below 60 is ischaemia, above 70 is ARDS. The external ventricular drain (EVD) is the gold standard because it does three jobs no other device can: it measures, drains, and samples the CSF; the intraparenchymal microsensor (Codman, Camino, Spiegelberg) is accurate to ±2 mmHg but cannot drain. The normal ICP waveform has three peaks — P1 (arterial percussion), P2 (tidal wave, reflects compliance), P3 (venous dicrotic); a P2 rising above P1 means compliance is exhausted. The Lundberg A-wave (the plateau wave — a sudden sustained rise that crashes the CPP) is pathological and needs urgent treatment.[1][15]

Meet the patient

A 24-year-old man is in neurocritical care 36 hours after a severe traumatic brain injury (GCS 5 at the scene). He has an external ventricular drain and an intraparenchymal bolt in situ. The ICP has been steady at 16 mmHg with a CPP of 65, the trace showing a crisp P1 above P2.[1]

At 3 am the ICP alarm fires: the number is 45 mmHg, the trace has flattened into a plateau, and his right pupil has blown to 6 mm. Two questions now decide everything — is there a surgical lesion to evacuate, and is the brain on the steep part of its compliance curve? Hold those two and the whole escalation staircase slots into place.[1]

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References18ShowHide
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  2. [2]Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow AD, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ; RESCUEicp Trial Collaborators. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension N Engl J Med, 2016.PMID 27602507
  3. [3]Chesnut RM, Temkin N, Carney N, Dikmen S, Rondina C, Videtta W, Petroni G, Lujan S, Pridgeon J, Barber J, Machamer J, Chaddock K, Celix JM, Cherner M, Hendrix T; Global Neurotrauma Research Group. A trial of intracranial-pressure monitoring in traumatic brain injury N Engl J Med, 2012.PMID 23234472
  4. [4]Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA. The role of secondary brain injury in determining outcome from severe head injury J Trauma, 1993.PMID 8459458
  5. [5]Lundberg N. Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury. A preliminary report J Neurosurg, 1965.PMID 5832775
  6. [6]Czosnyka M, Smielewski P, Kirkpatrick P, et al. Monitoring of cerebral autoregulation in head-injured patients Stroke, 1996.PMID 8841340
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  8. [8]Cnossen MC, Huijben JA, van der Jagt M, et al. Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study Crit Care, 2017.PMID 28874206
  9. [9]Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury Crit Care Med, 2002.PMID 11940737
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  11. [11]Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, Uzura M, Grossman RG. Prevention of secondary ischemic insults after severe head injury Crit Care Med, 1999.PMID 10548187
  12. [12]Stein KY, Froese L, Gomez A, Sainbhi AS, Vakitbilir N, Ibrahim Y, Zeiler FA. Intracranial Pressure Monitoring and Treatment Thresholds in Acute Neural Injury: A Narrative Review of the Historical Achievements, Current State, and Future Perspectives Neurotrauma Rep, 2023.PMID 37636334
  13. [13]Fink ME. Osmotherapy for intracranial hypertension: mannitol versus hypertonic saline Continuum (Minneap Minn), 2012.PMID 22810253
  14. [15]Castellani G, Zweifel C, Kim DJ, Carrera E, Radolovich DK, Smielewski P, Hutchinson PJ, Pickard JD, Czosnyka M. Plateau waves in head injured patients requiring neurocritical care Neurocrit Care, 2009.PMID 19565359
  15. [16]Hawryluk GWJ, Aguilera S, Buki A, Bulger E, Citerio G, Cooper DJ, Chesnut RM. A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) Intensive Care Med, 2019.PMID 31659383
  16. [17]Schizodimos T, Soulountsi V, Iasonidou C, Kapravelos N. An overview of management of intracranial hypertension in the intensive care unit J Anesth, 2020.PMID 32440802
  17. [18]Kramer AH, Couillard PL, Zygun DA, Aries MJ, Gallagher CN. Continuous Assessment of "Optimal" Cerebral Perfusion Pressure in Traumatic Brain Injury: A Cohort Study of Feasibility, Reliability, and Relation to Outcome Neurocrit Care, 2019.PMID 29987688
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