ICU · Haematology / coagulation

Anticoagulants & Antiplatelets — Heparin, DOACs, Warfarin & Reversal

Also known as Heparin · Unfractionated heparin · UFH · LMWH · Enoxaparin · Fondaparinux · DOAC · Dabigatran · Rivaroxaban · Apixaban · Edoxaban · Warfarin · Protamine · Idarucizumab · Andexanet alfa · PCC · Four-factor PCC · Antiplatelet · Aspirin · Clopidogrel · Ticagrelor · Prasugrel · Heparin-induced thrombocytopenia · HIT · 4Ts score · Argatroban · Bivalirudin · HAS-BLED · Vitamin K · Phytomenadione

The anticoagulants and the antiplatelets in the ICU: the heparins (the UFH — the antithrombin-mediated IIa or Xa, the APTT monitoring, the protamine reversal 1 mg per 100 U; the LMWH — the anti-Xa, the enoxaparin 1 mg per kg BD, the partial protamine reversal about 60 per cent, the avoid the CrCl under 30; the fondaparinux — the not reversible); the DOACs (the dabigatran — the direct IIa — the idarucizumab 5 g; the apixaban, the rivaroxaban, the edoxaban — the direct Xa — the andexanet alfa or the PCC); the warfarin (the vitamin-K antagonist, the INR — the reversal the vitamin K 10 mg IV plus the PCC 25 to 50 IU/kg, the FFP the slower); the antiplatelets (the aspirin — the COX-1, the irreversible 7 to 10 days — the platelet transfusion; the clopidogrel, the prasugrel, the ticagrelor — the P2Y12 — the platelet transfusion); the heparin-induced thrombocytopenia (the 4Ts the score, the argatroban or the bivalirudin); the bleeding risk (the HAS-BLED). The reversal in the major bleed or the emergency surgery — the stop the agent, the specific the reversal (the protamine, the idarucizumab, the andexanet, the PCC plus the vitamin K, the platelets), the supportive.