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ICU TopicsGI/Nutrition

ICU · GI/Nutrition

Acute mesenteric ischaemia

Also known as Mesenteric ischaemia · Bowel ischaemia · Intestinal infarction · Non-occlusive mesenteric ischaemia (NOMI) · SMA embolism · Mesenteric venous thrombosis

Acute mesenteric ischaemia is a life-threatening vascular emergency of the bowel. Four types: (1) SMA embolus (1 — atrial fibrillation, 50%), (2) SMA thrombosis (pre-existing atherosclerosis, 25%), (3) Non-occlusive (NOMI — low-flow state, 20%), (4) Mesenteric venous thrombosis (5%). Presents with SEVERE abdominal pain OUT OF PROPORTION to examination findings. Diagnosis: CT angiography (gold standard — shows occlusion, bowel wall thickening, pneumatosis, portal venous gas). Lactate elevated (late sign — bowel infarction). Management by type: emboli to embolectomy, thrombosis to bypass/stent, NOMI to intra-arterial papaverine, venous thrombosis to anticoagulation. Mortality 50-80% overall, highest for SMA thrombosis. WSES staging guides operative vs endovascular strategy. Time is bowel.

medium16 referencesUpdated 26 July 202616 min readVerification in progress

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Red flags

  • Severe abdominal pain OUT OF PROPORTION to examination = mesenteric ischaemia until proven otherwise
  • Lactate elevation is a LATE sign — indicates transmural infarction. Do NOT wait for lactate to rise
  • Mortality 50-80% — delay is the biggest killer. Time is bowel
  • AF patient with sudden severe abdominal pain = SMA embolus until proven otherwise
  • ICU patient on high-dose vasopressors with rising lactate and abdominal distension = NOMI
  • Peritonism, pneumatosis intestinalis or portal venous gas = transmural infarction — emergency laparotomy
  • Painless presentation in the sedated/ventilated ICU patient — diagnosis is often made late
  • Noradrenaline and vasopressin worsen mesenteric perfusion — use lowest effective dose
  • SMA thrombosis has the highest mortality (70-90%) — occlusion at the origin sacrifices the entire SMA territory
  • Do NOT delay CTA for oral contrast — intravenous contrast arterial and venous phase only
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Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Severe abdominal pain OUT OF PROPORTION to examination = mesenteric ischaemia until proven otherwise
  • Lactate elevation is a LATE sign — indicates transmural infarction. Do NOT wait for lactate to rise
  • Mortality 50-80% — delay is the biggest killer. Time is bowel
  • AF patient with sudden severe abdominal pain = SMA embolus until proven otherwise
  • ICU patient on high-dose vasopressors with rising lactate and abdominal distension = NOMI
  • Peritonism, pneumatosis intestinalis or portal venous gas = transmural infarction — emergency laparotomy
  • Painless presentation in the sedated/ventilated ICU patient — diagnosis is often made late
  • Noradrenaline and vasopressin worsen mesenteric perfusion — use lowest effective dose
  • SMA thrombosis has the highest mortality (70-90%) — occlusion at the origin sacrifices the entire SMA territory
  • Do NOT delay CTA for oral contrast — intravenous contrast arterial and venous phase only
In one line

Acute mesenteric ischaemia (AMI) is a vascular emergency of the bowel that kills 50–80% of patients and that you cannot afford to diagnose late. Four mechanisms starve the midgut: SMA embolus (the commonest — atrial fibrillation, ~50%), SMA thrombosis (atherosclerotic occlusion at the origin), non-occlusive (NOMI — low-flow vasospasm), and mesenteric venous thrombosis. The signature is severe abdominal pain out of proportion to a soft abdomen. CT angiography is the gold standard, and a normal lactate does not exclude it — lactate is a late, transmural sign. Treat by mechanism: embolus to embolectomy, thrombosis to bypass or stent, NOMI to intra-arterial papaverine, venous thrombosis to anticoagulation. Time is bowel.

[1]
Management in one line per type
  • SMA embolus → embolectomy (open surgical or endovascular aspiration) or catheter-directed thrombolysis when there is no peritonitis; revascularise before resection of doubtful bowel and plan a pre-planned second look (24–48 h).
  • SMA thrombosis → endovascular stenting of the proximal SMA occlusion or open surgical bypass (aorto/iliac to SMA) if no peritonitis. Highest mortality of the four (~77%).
  • NOMI → treat the low-flow state: correct hypovolaemia, optimise cardiac output and minimise vasoconstriction (stop or reduce vasopressors); catheter-directed intra-arterial vasodilator infusion (papaverine) into the SMA is associated with improved survival.
  • Mesenteric venous thrombosis → anticoagulation is the first-line treatment (continuous unfractionated heparin infusion, later transitioned to oral anticoagulation); thrombophilia-screen; operate only for infarction or peritonitis.
[1] [2] [3] [5] [14]

Meet the patient

A 78-year-old man with permanent atrial fibrillation — off anticoagulation since a fall last week — arrives at 3am with sudden, crushing periumbilical pain. He is writhing, vomiting, and begging for analgesia, yet his abdomen is soft and non-tender with active bowel sounds. His blood pressure is preserved and the venous lactate is 1.6 mmol/L.[1]

This is the disease that punishes patience. The two questions that decide whether he survives the night are the two you must learn to ask first: is this pain out of proportion to the exam? (the bedside pattern says yes), and have I ordered the CT angiogram yet? (the only test that can save his bowel). Do not wait for the lactate to climb — by the time it does, the bowel is often already dead.[1]

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References16ShowHide
  1. [1]Fuglseth H, Søreide K, Vetrhus M Acute mesenteric ischaemia. The British journal of surgery, 2023.PMID 36748996
  2. [2]Reintam Blaser A, Coopersmith CM, Acosta S Managing acute mesenteric ischaemia. Intensive care medicine, 2024.PMID 38478026
  3. [3]Bala M, Catena F, Kashuk J, et al. Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery. World journal of emergency surgery : WJES, 2022.PMID 36261857
  4. [4]Kougias P, Huynh TT, Lin PH Clinical outcomes of mesenteric artery stenting versus surgical revascularization in chronic mesenteric ischemia. International angiology : a journal of the International Union of Angiology, 2009.PMID 19367243
  5. [5]Schoots IG, Koffeman GI, Legemate DA, et al. Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. The British journal of surgery, 2004.PMID 14716789
  6. [6]Acosta S, Salim S Management of Acute Mesenteric Venous Thrombosis: A Systematic Review of Contemporary Studies. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2021.PMID 33118463
  7. [7]Tamme K, Reintam Blaser A, Laisaar KT, et al. Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis. BMJ open, 2022.PMID 36283747
  8. [8]Reintam Blaser A, Starkopf J, Björck M, et al. Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis. World journal of emergency surgery : WJES, 2023.PMID 37658356
  9. [9]Srisajjakul S, Prapaisilp P, Bangchokdee S Comprehensive review of acute small bowel ischemia: CT imaging findings, pearls, and pitfalls. Emergency radiology, 2022.PMID 35122558
  10. [10]Cudnik MT, Darbha S, Jones J, et al. The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013.PMID 24238311
  11. [11]Singal AK, Kamath PS, Tefferi A Mesenteric venous thrombosis. Mayo Clinic proceedings, 2013.PMID 23489453
  12. [12]MacCannell KL Comparison of an intravenous selective mesenteric vasodilator with intraarterial papaverine in experimental nonocclusive mesenteric ischemia. Gastroenterology, 1986.PMID 3710084
  13. [13]Reintam Blaser A, Koitmäe M, Laisaar KT, et al. Radiological diagnosis of acute mesenteric ischemia in adult patients: a systematic review and meta-analysis. Scientific reports, 2025.PMID 40119151
  14. [14]Winzer R, Fedders D, Backes M, et al. Local Intra-arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia Significantly Increases Survival Rate. Cardiovascular and interventional radiology, 2020.PMID 32444922
  15. [15]Stahl K, Rittgerodt N, Busch M, et al. Nonocclusive Mesenteric Ischemia and Interventional Local Vasodilatory Therapy: A Meta-Analysis and Systematic Review of the Literature. Journal of intensive care medicine, 2020.PMID 31645176
  16. [16]Takami T, Mizuno K, Obama K, et al. Association of Perioperative Vasodilator Therapy and Mortality in Nonocclusive Mesenteric Ischemia. The Journal of surgical research, 2025.PMID 40997653

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