ICU · GI/Nutrition
Acute mesenteric ischaemia
Also known as Mesenteric ischaemia · Bowel ischaemia · Intestinal infarction · Non-occlusive mesenteric ischaemia (NOMI) · SMA embolism · Mesenteric venous thrombosis
Acute mesenteric ischaemia is a life-threatening vascular emergency of the bowel. Four types: (1) SMA embolus (1 — atrial fibrillation, 50%), (2) SMA thrombosis (pre-existing atherosclerosis, 25%), (3) Non-occlusive (NOMI — low-flow state, 20%), (4) Mesenteric venous thrombosis (5%). Presents with SEVERE abdominal pain OUT OF PROPORTION to examination findings. Diagnosis: CT angiography (gold standard — shows occlusion, bowel wall thickening, pneumatosis, portal venous gas). Lactate elevated (late sign — bowel infarction). Management by type: emboli to embolectomy, thrombosis to bypass/stent, NOMI to intra-arterial papaverine, venous thrombosis to anticoagulation. Mortality 50-80% overall, highest for SMA thrombosis. WSES staging guides operative vs endovascular strategy. Time is bowel.
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Red flags
- Severe abdominal pain OUT OF PROPORTION to examination = mesenteric ischaemia until proven otherwise
- Lactate elevation is a LATE sign — indicates transmural infarction. Do NOT wait for lactate to rise
- Mortality 50-80% — delay is the biggest killer. Time is bowel
- AF patient with sudden severe abdominal pain = SMA embolus until proven otherwise
- ICU patient on high-dose vasopressors with rising lactate and abdominal distension = NOMI
- Peritonism, pneumatosis intestinalis or portal venous gas = transmural infarction — emergency laparotomy
- Painless presentation in the sedated/ventilated ICU patient — diagnosis is often made late
- Noradrenaline and vasopressin worsen mesenteric perfusion — use lowest effective dose
- SMA thrombosis has the highest mortality (70-90%) — occlusion at the origin sacrifices the entire SMA territory
- Do NOT delay CTA for oral contrast — intravenous contrast arterial and venous phase only
Meet the patient
A 78-year-old man with permanent atrial fibrillation — off anticoagulation since a fall last week — arrives at 3am with sudden, crushing periumbilical pain. He is writhing, vomiting, and begging for analgesia, yet his abdomen is soft and non-tender with active bowel sounds. His blood pressure is preserved and the venous lactate is 1.6 mmol/L.[1]
This is the disease that punishes patience. The two questions that decide whether he survives the night are the two you must learn to ask first: is this pain out of proportion to the exam? (the bedside pattern says yes), and have I ordered the CT angiogram yet? (the only test that can save his bowel). Do not wait for the lactate to climb — by the time it does, the bowel is often already dead.[1]
References16ShowHide
- [1]Fuglseth H, Søreide K, Vetrhus M Acute mesenteric ischaemia. The British journal of surgery, 2023.PMID 36748996
- [2]Reintam Blaser A, Coopersmith CM, Acosta S Managing acute mesenteric ischaemia. Intensive care medicine, 2024.PMID 38478026
- [3]Bala M, Catena F, Kashuk J, et al. Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery. World journal of emergency surgery : WJES, 2022.PMID 36261857
- [4]Kougias P, Huynh TT, Lin PH Clinical outcomes of mesenteric artery stenting versus surgical revascularization in chronic mesenteric ischemia. International angiology : a journal of the International Union of Angiology, 2009.PMID 19367243
- [5]Schoots IG, Koffeman GI, Legemate DA, et al. Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. The British journal of surgery, 2004.PMID 14716789
- [6]Acosta S, Salim S Management of Acute Mesenteric Venous Thrombosis: A Systematic Review of Contemporary Studies. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2021.PMID 33118463
- [7]Tamme K, Reintam Blaser A, Laisaar KT, et al. Incidence and outcomes of acute mesenteric ischaemia: a systematic review and meta-analysis. BMJ open, 2022.PMID 36283747
- [8]Reintam Blaser A, Starkopf J, Björck M, et al. Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis. World journal of emergency surgery : WJES, 2023.PMID 37658356
- [9]Srisajjakul S, Prapaisilp P, Bangchokdee S Comprehensive review of acute small bowel ischemia: CT imaging findings, pearls, and pitfalls. Emergency radiology, 2022.PMID 35122558
- [10]Cudnik MT, Darbha S, Jones J, et al. The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013.PMID 24238311
- [11]Singal AK, Kamath PS, Tefferi A Mesenteric venous thrombosis. Mayo Clinic proceedings, 2013.PMID 23489453
- [12]MacCannell KL Comparison of an intravenous selective mesenteric vasodilator with intraarterial papaverine in experimental nonocclusive mesenteric ischemia. Gastroenterology, 1986.PMID 3710084
- [13]Reintam Blaser A, Koitmäe M, Laisaar KT, et al. Radiological diagnosis of acute mesenteric ischemia in adult patients: a systematic review and meta-analysis. Scientific reports, 2025.PMID 40119151
- [14]Winzer R, Fedders D, Backes M, et al. Local Intra-arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia Significantly Increases Survival Rate. Cardiovascular and interventional radiology, 2020.PMID 32444922
- [15]Stahl K, Rittgerodt N, Busch M, et al. Nonocclusive Mesenteric Ischemia and Interventional Local Vasodilatory Therapy: A Meta-Analysis and Systematic Review of the Literature. Journal of intensive care medicine, 2020.PMID 31645176
- [16]Takami T, Mizuno K, Obama K, et al. Association of Perioperative Vasodilator Therapy and Mortality in Nonocclusive Mesenteric Ischemia. The Journal of surgical research, 2025.PMID 40997653