ICU · GI & nutrition / surgical
Acute lower gastrointestinal bleeding — diverticular, angiodysplasia, colitis and the resuscitate-to-surgery pathway
Also known as Lower GI bleed · LGIB · Hematochezia · Diverticular bleed · Massive rectal bleeding · Angiodysplasia · Ischaemic colitis · Oakland score · CT angiography · Tagged RBC scan · Angioembolisation · Subtotal colectomy · Heyde syndrome · Aortoenteric fistula
Acute lower gastrointestinal bleeding (LGIB) is bleeding arising distal to the ligament of Treitz, presenting most often with hematochezia (bright red blood per rectum) and less commonly with maroon stools or right-sided melena. The dominant causes are diverticular bleeding (the commonest cause — painless, massive, self-limiting), colonic angiodysplasia (painless and recurrent in the elderly), colitis (ischaemic, inflammatory and infectious), anorectal sources such as haemorrhoids, and colorectal malignancy or post-polypectomy. Most bleeds stop spontaneously. The management ladder is resuscitation with crystalloid and restrictive transfusion (TRICC trigger Hb <70 g/L) → exclude an upper GI source (upper endoscopy when hematochezia accompanies haemodynamic instability) → bowel preparation and colonoscopy (nonurgent for most inpatients; urgent within 24 h reserved for higher-risk patients) → CT angiography (CTA) for brisk ongoing bleeding or when colonoscopy is non-diagnostic → catheter mesenteric angiography with superselective embolisation if CTA is positive → and segmental or subtotal colectomy as the last resort for refractory haemorrhage. The Oakland score (threshold <=8, 95% probability of safe discharge in derivation) identifies low-risk patients safe for outpatient management. Cause-specific management differs: diverticular (endoscopic haemostasis, often self-limiting), angiodysplasia (ablation, consider aortic stenosis / Heyde syndrome), IBD (treat the flare, avoid over-instrumentation), ischaemic colitis (supportive — fluids, antibiotics, no endoscopic therapy unless right-sided/gangrenous).
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Red flags
- Massive hematochezia can be an UPPER GI source with rapid transit — always exclude an upper source with NG aspirate or gastroscopy before committing to a colonoscopic pathway.
- Most lower GI bleeds stop spontaneously — resuscitate, observe and localise; do NOT rush to surgery.
- Aortoenteric fistula: a prior aortic graft plus a small herald rectal/melaena bleed is a fistula until proven otherwise — the next bleed is exsanguinating. CT angiography (NOT endoscopic biopsy) is diagnostic; urgent vascular surgery.
- Anticoagulated patient: reverse carefully and individually — balance bleeding against thrombosis (mechanical valve, recent stent). Do NOT reflexively reverse everything.
- Diverticular bleed: painless, massive, often self-limiting — but recurrence after a first bleed is well recognised; surgery to prevent recurrent bleeding is individualised and requires localisation before resection.
- Ischaemic colitis: elderly patient with abdominal pain BEFORE the bleed — this is a different pathway (supportive care), not endoscopic therapy. Right-sided ischaemic colitis carries the highest mortality and may need surgery.
- Restrictive transfusion (Hb 70 g/L trigger per TRICC) — over-transfusion in a colonic bleed carries TACO/TRALI/infection risk; LGIB-specific randomised evidence is awaited.
Meet the patient
A 76-year-old man, four years out from an open abdominal aortic aneurysm repair and on aspirin alone, is wheeled in at 4 am having soaked the bed with bright red blood per rectum. He recalls a small "herald" motion six hours earlier he put down to his haemorrhoids; now his blood pressure is 92/58, heart rate 118, and he is pale, cool and clammy.[1]
Two questions decide his next hour, and they decide every LGIB: where is it bleeding from — upper or lower? (a bleeding duodenal ulcer in fast transit looks identical), and is that aortic graft about to exsanguinate him? (an aortoenteric fistula until proven otherwise). Hold those two questions and the whole ladder slots into place.[1]
References12ShowHide
- [1]Strate LL, Gralnek IM. ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding Am J Gastroenterol, 2016.PMID 26925883
- [2]Sengupta N, Feuerstein JD, Jairath V, et al. Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline Am J Gastroenterol, 2023.PMID 36735555
- [3]Oakland K, Jairath V, Uberoi R, et al. Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study Lancet Gastroenterol Hepatol, 2017.PMID 28651935
- [4]Green BT, Rockey DC, Portwood G, et al. Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial Am J Gastroenterol, 2005.PMID 16279891
- [5]Oakland K, Chadwick G, East JE, et al. Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology Gut, 2019.PMID 30792244
- [6]Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care N Engl J Med, 1999.PMID 9971864
- [7]Oakland K, Kothiwale S, Forehand T, et al. External Validation of the Oakland Score to Assess Safe Hospital Discharge Among Adult Patients With Acute Lower Gastrointestinal Bleeding in the US JAMA Netw Open, 2020.PMID 32633766
- [8]Almaghrabi M, Gandhi M, Guizzetti L, et al. Comparison of Risk Scores for Lower Gastrointestinal Bleeding: A Systematic Review and Meta-analysis JAMA Netw Open, 2022.PMID 35622365
- [9]Oakland K, Desborough MJ, Murphy MF, et al. Rebleeding and Mortality After Lower Gastrointestinal Bleeding in Patients Taking Antiplatelets or Anticoagulants Clin Gastroenterol Hepatol, 2019.PMID 29277620
- [10]Kherad O, Restellini S, Martel M, et al. Outcomes following restrictive or liberal red blood cell transfusion in patients with lower gastrointestinal bleeding Aliment Pharmacol Ther, 2019.PMID 30805962
- [11]Laursen SB, Oakland K, Laine L, et al. ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study Gut, 2021.PMID 32723845
- [12]Oakland K. Changing epidemiology and etiology of upper and lower gastrointestinal bleeding Best Pract Res Clin Gastroenterol, 2019.PMID 31785737