ICU · Ethics
Geriatric critical care: the elderly ICU patient
Also known as Elderly ICU · Geriatric ICU · Frailty in ICU · Older critical care patient · Age and critical illness
Geriatric critical care: patients aged 65-80 in ICU. Physiological changes of ageing: reduced organ reserve (cardiac, renal, respiratory), altered pharmacokinetics (decreased renal clearance, increased body fat, decreased albumin), polypharmacy, frailty, comorbidities. Key principles: (1) FRAILTY (not age alone) predicts outcomes better than chronological age. (2) Polypharmacy — review all medications, deprescribe. (3) Delirium — extremely common in elderly ICU, worsens outcomes. (4) Iatrogenic complications (infections, bleeding, falls). (5) Goals of care discussions — realistic prognosis, quality of life. (6) Early mobilisation — prevents deconditioning. (7) Nutrition — sarcopenia. Outcomes: higher mortality, longer recovery, more disability…
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- Frailty (not age) predicts outcomes — assess with Clinical Frailty Scale
- Delirium in elderly ICU — extremely common, worsens mortality and cognitive outcomes
- Polypharmacy — medication review essential, deprescribe nephrotoxic/sedatives
- Goals of care — realistic discussion about prognosis, quality of life, advance care planning
Meet the patient
An 82-year-old woman with urosepsis, on a walking frame before admission, needing help with shopping and her finances. She is septic on noradrenaline, her creatinine is 230, and the registrar asks how you will explain her prognosis. The first move is not a number on a score — it is a telephone call to her daughter for the two weeks before this illness.[1]
The single question that reframes geriatric critical care is this: how was she before? Chronological age is a poor predictor; the pre-morbid baseline — captured in one minute by the Clinical Frailty Scale — is the variable that actually forecasts who lives, who goes home, and who never does.[1]
- Assess frailty — Clinical Frailty Scale (1-9). Frailty (at least 5) is independently associated with ICU mortality after adjustment for age, sex and illness acuity, and with institutionalisation after critical illness.[6]
- Medication review — reconcile, deprescribe, adjust doses for renal and hepatic function, screen for potentially inappropriate medications (Beers), cut polypharmacy: medication stewardship reduces medication-related harm in older ICU patients.[23][16]
- Prevent delirium — assess and manage pain, target light sedation, protect the sleep-wake cycle, orient, family at the bedside, glasses and hearing aids, mobilise early, avoid restraints.[9][11]
- Mobilise early — progress mobility daily; complete ABCDEF bundle performance is associated with less delirium, coma, physical restraint use and next-day mechanical ventilation.[19]
- Nutrition — assess for sarcopenia and malnutrition risk, feed enterally, meet protein targets while advancing calories gradually in the first days.[21][22]
- Goals of care — realistic prognosis, quality of life, advance care planning, involve family, consider palliative care, respect advance directives.[7]
- Plan discharge and survivorship — rehabilitation, community support, ICU follow-up; plan for post-intensive care syndrome (cognitive, physical, psychological).[3][5]
References24ShowHide
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- [2]Ferrante LE, Vallet H, Ho JQ, Brummel NE, et al. Challenges and strategies in the care of older adults across the continuum of intensive and post-intensive care medicine Intensive Care Med, 2026.PMID 41428207
- [3]Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness N Engl J Med, 2013.PMID 24088092
- [4]Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU) JAMA, 2001.PMID 11730446
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- [9]Devlin JW, Skrobik Y, Gélinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Crit Care Med, 2018.PMID 30113379
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- [12]Marra A, Ely EW, Pandharipande PP, et al. The ABCDEF Bundle in Critical Care Crit Care Clin, 2017.PMID 28284292
- [13]Adigbli DK, Hammond NE, Finfer S, et al. Managing blood glucose in the intensive care unit Intensive Care Med, 2025.PMID 39714614
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- [16]American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults J Am Geriatr Soc, 2023.PMID 37139824
- [17]Fernando SM, McIsaac DI, Perry JJ, Bagshaw SM, et al. Frailty and Associated Outcomes and Resource Utilization Among Older ICU Patients With Suspected Infection Crit Care Med, 2019.PMID 31135504
- [18]Muscedere J, Bagshaw SM, Kho M, et al. Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study Intensive Care Med, 2024.PMID 38748266
- [19]Pun BT, Balas MC, Barnes-Daly MA, et al. Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults Crit Care Med, 2019.PMID 30339549
- [20]Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype J Gerontol A Biol Sci Med Sci, 2001.PMID 11253156
- [21]Singer P, Blaser AR, Berger MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit Clin Nutr, 2019.PMID 30348463
- [22]Arabi YM, Aldawood AS, Haddad SH, et al. Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults N Engl J Med, 2015.PMID 25992505
- [23]Zerah L, et al. Multimorbidity, polypharmacy and frailty in critically ill older adults Eur Geriatr Med, 2026.PMID 42091783
- [24]Yuan JH, et al. Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty J Am Geriatr Soc, 2024.PMID 38819605