ICU · Endocrine & metabolic emergencies
Endocrine & Metabolic Derangements of Critical Illness
Also known as Metabolic response to critical illness · Stress hyperglycaemia · Sick euthyroid syndrome · Low T3 syndrome · Critical illness-related corticosteroid insufficiency · CIRCI · Anabolic failure · ICU-acquired weakness
endocrine metabolic response to the critical the illness — the the biphasic (acute adaptive stress response → chronic maladaptive persistent). The acute: the counter-regulatory the hormones (the cortisol, the catecholamines, the glucagon, the GH), the insulin the resistance (the stress the hyperglycaemia), the hypercatabolism. The chronic: the suppressed the axes (the sick the euthyroid / the low-T3, the hypogonadism, the CIRCI), the anabolic the failure, the muscle the wasting. moderate glycaemic control (the NICE-SUGAR); the hydrocortisone for refractory septic shock; sick euthyroid no replacement. rarer ICU endocrinopathies — the insulinoma (the spontaneous the hypoglycaemia), the VIPoma (the secretory the diarrhoea, the hypokalaemia), the carcinoid / the carcinoid the crisis, the calcitonin in the thyroid the C-cell (the medullary the carcinoma). The hyperglycaemic the emergencies (the DKA / the HHS) the summarised — the detail in the sibling.
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A 68-year-old man is on ICU day 2 after a three-vessel CABG on cardiopulmonary bypass. He is in new atrial fibrillation, has had amiodarone and iodinated contrast, and his routine bloods are unremarkable except the thyroid function tests the registrar sent: TSH 0.4, free T3 2.1, free T4 14. The registrar documents possible hypothyroidism and asks whether to start levothyroxine.[1]
The answer is no. This is sick euthyroid — the adaptive down-regulation of the thyroid axis in critical illness — and replacing thyroid hormone here does not help and may harm. The same patient will develop stress hyperglycaemia and may need hydrocortisone if his shock becomes refractory. The whole topic turns on knowing which derangements to treat and which to leave alone.[6]
References23ShowHide
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