ICU · Endocrine & metabolic emergencies
Adrenal Crisis & Corticosteroid Replacement
Also known as Adrenal crisis · Addisonian crisis · Adrenal insufficiency · HPA suppression · Stress-dose steroids · Corticosteroid withdrawal · Waterhouse-Friderichsen
The adrenal crisis — the acute the life-threatening the glucocorticoid the deficiency. The causes (the primary — the Addison's, the adrenal the haemorrhage; the secondary — the pituitary; the iatrogenic — the abrupt the withdrawal of chronic exogenous steroids [the HPA the suppression] — commonest ICU cause). The refractory the hypotension, the abdominal the pain, the hyponatraemia, the hyperkalaemia, the hypoglycaemia. The hydrocortisone the IV the immediately (the before the tests), the fluid, the treat the trigger. The stress-dose the steroids for the chronic the users (the illness / the surgery).
Checked against its sources on 13 Oct 2026
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A woman in her sixties with rheumatoid arthritis on chronic prednisolone, stopped on admission days ago, is in septic shock from pneumonia. Despite crystalloid resuscitation she needs high-dose noradrenaline to hold pressure. Sodium low, potassium high, glucose low, cortisol low-normal. She has faint pigmentation in the palmar creases. Infections are the major precipitating factor for adrenal crisis, and the cessation or reduction of glucocorticoid doses is another — her steroids were stopped two days before the infection hit.[1][11]
The question at the bedside is always the same: in vasopressor-resistant shock with a chronic-steroid history, is the adrenal axis adequate for the stress? The safe answer, every time, is hydrocortisone first and confirm later — the test takes days, the crisis takes hours.[1]
References18ShowHide
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- [3]Komminoth M, Donath MY, Hepprich M, et al. Glucocorticoid withdrawal and glucocorticoid-induced adrenal insufficiency: Study protocol of the randomized controlled «TOASST (Taper Or Abrupt Steroid STop) multicenter trial PLoS One, 2023.PMID 37018188
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- [17]Cheung YT, et al. Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition. Steroids, 2025.PMID 40451601
- [18]Hahner S, Spinnler C, Fassnacht M, et al. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study. J Clin Endocrinol Metab, 2015.PMID 25419882