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ICU TopicsEndocrine & metabolic emergencies

ICU · Endocrine & metabolic emergencies

Adrenal Crisis & Corticosteroid Replacement

Also known as Adrenal crisis · Addisonian crisis · Adrenal insufficiency · HPA suppression · Stress-dose steroids · Corticosteroid withdrawal · Waterhouse-Friderichsen

The adrenal crisis — the acute the life-threatening the glucocorticoid the deficiency. The causes (the primary — the Addison's, the adrenal the haemorrhage; the secondary — the pituitary; the iatrogenic — the abrupt the withdrawal of chronic exogenous steroids [the HPA the suppression] — commonest ICU cause). The refractory the hypotension, the abdominal the pain, the hyponatraemia, the hyperkalaemia, the hypoglycaemia. The hydrocortisone the IV the immediately (the before the tests), the fluid, the treat the trigger. The stress-dose the steroids for the chronic the users (the illness / the surgery).

high18 referencesUpdated 26 July 202615 min readSource-verified · Oct 2026

Checked against its sources on 13 Oct 2026

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The one-line answer

Adrenal crisis is an acute, life-threatening episode of adrenal insufficiency — an acute deterioration in multi-organ homeostasis that, untreated, progresses to shock and death. Precipitants include infection, surgery and the cessation or reduction of glucocorticoid doses, and iatrogenic adrenal insufficiency is the commonest form of adrenal insufficiency in adults. Give hydrocortisone as an initial IV bolus of 100 mg, then 200 mg per 24 hours (continuous infusion or 50 mg boluses every 6 hours) with 0.9 per cent saline, immediately and before any diagnostic test, and find the trigger.[11][2]

Meet the patient

A woman in her sixties with rheumatoid arthritis on chronic prednisolone, stopped on admission days ago, is in septic shock from pneumonia. Despite crystalloid resuscitation she needs high-dose noradrenaline to hold pressure. Sodium low, potassium high, glucose low, cortisol low-normal. She has faint pigmentation in the palmar creases. Infections are the major precipitating factor for adrenal crisis, and the cessation or reduction of glucocorticoid doses is another — her steroids were stopped two days before the infection hit.[1][11]

The question at the bedside is always the same: in vasopressor-resistant shock with a chronic-steroid history, is the adrenal axis adequate for the stress? The safe answer, every time, is hydrocortisone first and confirm later — the test takes days, the crisis takes hours.[1]

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References18ShowHide
  1. [1]Dineen R, Thompson CJ, Sherlock M Adrenal crisis: prevention and management in adult patients Ther Adv Endocrinol Metab, 2019.PMID 31223468
  2. [2]Martin-Grace J, Tomkins M, O'Reilly MW, et al. Iatrogenic adrenal insufficiency in adults Nat Rev Endocrinol, 2024.PMID 38272995
  3. [3]Komminoth M, Donath MY, Hepprich M, et al. Glucocorticoid withdrawal and glucocorticoid-induced adrenal insufficiency: Study protocol of the randomized controlled «TOASST (Taper Or Abrupt Steroid STop) multicenter trial PLoS One, 2023.PMID 37018188
  4. [4]Venkatesh B, Finfer S, Cohen J, et al. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock N Engl J Med, 2018.PMID 29347874
  5. [5]Annane D, Renault A, Brun-Buisson C, et al. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock N Engl J Med, 2018.PMID 29490185
  6. [6]Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock N Engl J Med, 2008.PMID 18184957
  7. [7]Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metab, 2016.PMID 26760044
  8. [8]Annane D, Pastores SM, Rochwerg B, et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 Intensive Care Med, 2017.PMID 28940011
  9. [9]Chan CM, Mitchell AL, Shorr AF Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis* Crit Care Med, 2012.PMID 22971586
  10. [10]Bruder EA, Ball IM, Ridi S, et al. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients Cochrane Database Syst Rev, 2015.PMID 25568981
  11. [11]Martel-Duguech L, Poirier J, Bourdeau I, et al. Diagnosis and management of secondary adrenal crisis. Rev Endocr Metab Disord, 2024.PMID 38411891
  12. [12]Annane D, Sébille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA, 2002.PMID 12186604
  13. [13]Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet, 2009.PMID 19573904
  14. [14]Yo WS, Toh LM, Brown SJ, et al. How good is a morning cortisol in predicting an adequate response to intramuscular synacthen stimulation? Clin Endocrinol (Oxf), 2014.PMID 24274236
  15. [15]Meade-Aguilar JA, Figueroa-Parra G, Yang JX, et al. Clinical presentation and outcomes in patients with antiphospholipid syndrome-associated adrenal hemorrhage. A multicenter cohort study and systematic literature review. Clin Immunol, 2024.PMID 38244823
  16. [16]Barthel A, Benker G, Berens K, et al. An Update on Addison's Disease. Exp Clin Endocrinol Diabetes, 2019.PMID 30562824
  17. [17]Cheung YT, et al. Acquired 11β-Hydroxylase deficiency in etomidate and (Iso)propoxate abusers: A nascent endocrine condition. Steroids, 2025.PMID 40451601
  18. [18]Hahner S, Spinnler C, Fassnacht M, et al. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study. J Clin Endocrinol Metab, 2015.PMID 25419882
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