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ICU TopicsCardiovascular / valvular

ICU · Cardiovascular / valvular

Valvular Disease in the ICU

Also known as Valvular heart disease · Aortic stenosis · Aortic regurgitation · Mitral regurgitation · Mitral stenosis · TAVI · TAVR · Prosthetic valve · Valve thrombosis · Balloon mitral valvuloplasty · BMV · MitraClip · Papillary muscle rupture

Severe valvular disease in the ICU has valve-specific haemodynamic implications that determine what the patient can and cannot tolerate. Severe aortic stenosis (a stiff, hypertrophied LV) is preload-dependent and vasodilator-intolerant — avoid tachycardia, hypovolaemia, and vasodilation; use phenylephrine. Severe aortic and mitral regurgitation (volume overload) benefit from afterload reduction and a higher heart rate — use vasodilators and avoid bradycardia. Severe mitral stenosis (an obstructed inflow) needs rate control and avoids vasodilation. Maintain sinus rhythm in all (the atrial kick matters for the stiff or overloaded LV). Echocardiography is the diagnostic tool; the definitive treatment is surgical or percutaneous (AVR, TAVI/TAVR, MV repair, balloon mitral valvuloplasty). Prosthetic valves require lifelong anticoagulation (mechanical) and carry risks of thrombosis and infective endocarditis.

high26 referencesUpdated 20 Aug 202620 min readVerification in progress

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Severe valvular disease in the ICU is a haemodynamic-management problem, not a valve-repair problem — the intensivist's job is to preserve the conditions each lesion needs while the structural team is mobilised. Aortic stenosis (a stiff, preload-dependent LV) is vasodilator-intolerant: avoid tachycardia, hypovolaemia, and vasodilation, use phenylephrine, severe criteria an area under 1.0 cm², mean gradient over 40 mmHg, peak velocity over 4 m/s; definitive AVR or TAVR. Aortic and mitral regurgitation (a volume-overloaded LV) need afterload reduction and a higher heart rate — vasodilators, an IABP for acute MR, avoid bradycardia. Mitral stenosis (an obstructed inflow) needs rate control and shuns vasodilation. In every lesion, maintain sinus rhythm — the atrial kick is worth 30 to 40 per cent.

[1]

Meet the patient

A 78-year-old man with known severe aortic stenosis is on the unit at 3am. He has slipped into fast atrial fibrillation at 140, his blood pressure is 78/50, and he is flooding both lung fields. The registrar has reached for the metoprolol and is asking about a GTN infusion.[1]

The two questions that decide his next ten minutes are the two that decide every valvular emergency: what is the valve, and what does it tolerate? An echo before the drug, and the atrial kick restored — everything else follows.[1]

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References26ShowHide
  1. [1]Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines J Am Coll Cardiol, 2021.PMID 33342586
  2. [2]Baumgartner H, Falk V, Bax JJ, et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease Eur Heart J, 2017.PMID 28886619
  3. [3]Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery N Engl J Med, 2010.PMID 20961243
  4. [4]Smith CR, Leon MB, Mack MJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients N Engl J Med, 2011.PMID 21639811
  5. [5]Leon MB, Smith CR, Mack MJ, et al. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients N Engl J Med, 2016.PMID 27040324
  6. [6]Reardon MJ, Van Mieghem NM, Popma JJ, et al. Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients N Engl J Med, 2017.PMID 28304219
  7. [7]Popma JJ, Deeb GM, Yakubov SJ, et al. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients N Engl J Med, 2019.PMID 30883053
  8. [8]Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure N Engl J Med, 2018.PMID 30280640
  9. [9]Obadia JF, Messika-Zeitoun D, Leurent G, et al. Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation N Engl J Med, 2018.PMID 30145927
  10. [10]Thiele H, Zeymer U, Neumann FJ, et al. Intraaortic balloon support for myocardial infarction with cardiogenic shock N Engl J Med, 2012.PMID 22920912
  11. [11]Thiele RH, Nemergut EC, Lynch C 3rd The clinical implications of isolated alpha(1) adrenergic stimulation Anesth Analg, 2011.PMID 21519053
  12. [12]Safian RD, Berman AD, Diver DJ, et al. Balloon aortic valvuloplasty in 170 consecutive patients N Engl J Med, 1988.PMID 3386691
  13. [13]Spargias K, Gyöngyösi M, Hemetsberger R, et al. Valvuloplasty with a paclitaxel-eluting balloon prevents restenosis in an experimental animal model of aortic stenosis J Heart Valve Dis, 2014.PMID 25803975
  14. [14]Wilkins GT, Weyman AE, Abascal VM, et al. Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation Br Heart J, 1988.PMID 3190958
  15. [15]Sreerama D, Surana M, Moolchandani K, et al. Percutaneous balloon mitral valvotomy during pregnancy: A systematic review and meta-analysis Acta Obstet Gynecol Scand, 2021.PMID 33070306
  16. [16]Alahmadi MH, Haleem SM, Sharma S Mitral Stenosis StatPearls [Internet], 2026.PMID 28613493
  17. [17]Abdelrahman S, Yousif N Mitral Stenosis in Pregnancy: A Comprehensive Review of a Challenging Cardio-Obstetric Clinical Entity Rev Recent Clin Trials, 2019.PMID 30734684
  18. [18]El Hussein MT, Job D, Hakkola J Aortic Regurgitation: Review of Current Management Dimens Crit Care Nurs, 2024.PMID 38271313
  19. [19]Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease JAMA, 2000.PMID 10685714
  20. [20]Kang DH, Kim YJ, Kim SH, et al. Early surgery versus conventional treatment for infective endocarditis N Engl J Med, 2012.PMID 22738096
  21. [21]Sharma S, Burton LV, Beier K Papillary Muscle Rupture StatPearls [Internet], 2026.PMID 29763151
  22. [22]Gong FF, Vaitenas I, Malaisrie SC, Maganti K Mechanical Complications of Acute Myocardial Infarction: A Review JAMA Cardiol, 2021.PMID 33295949
  23. [23]Harshaw CW, Grossman W, Munro AB, McLaurin LP Reduced systemic vascular resistance as therapy for severe mitral regurgitation of valvular origin Ann Intern Med, 1975.PMID 1180426
  24. [24]Cáceres-Lóriga FM, Pérez-López H, Santos-Gracia J, et al. Prosthetic heart valve thrombosis: pathogenesis, diagnosis and management Int J Cardiol, 2006.PMID 16038994
  25. [25]Samarendra P, Mangione MP Aortic stenosis and perioperative risk with noncardiac surgery J Am Coll Cardiol, 2015.PMID 25614427
  26. [26]Clavel MA, Magne J, Pibarot P Low-gradient aortic stenosis Eur Heart J, 2016.PMID 27190103

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