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ICU TopicsPerioperative critical care

ICU · Perioperative critical care

Perioperative Critical Care

Also known as Perioperative medicine · High-risk surgery · Preoperative optimisation · Postoperative complications · Enhanced recovery · Goal-directed therapy · MINS · ERAS

Perioperative critical care is the optimisation of the high-risk surgical patient before, during, and after the operation — the preoperative risk assessment (the cardiopulmonary exercise testing, the POSSUM/ACS-NSQIP scoring, the smoking cessation, the anaemia correction, the glycaemic control), the enhanced recovery after surgery (ERAS) bundle, the intraoperative goal-directed therapy (the cardiac output, the fluid responsiveness, the stroke-volume optimisation, the oxygen delivery), the postoperative monitoring (the HDU/ICU), and the system-by-system complications (the cardiac — the AF and the myocardial injury after noncardiac surgery [MINS]; the respiratory — the atelectasis, the pneumonia, the PE; the renal — the AKI; the GI — the ileus and the anastomotic leak; the wound — the infection and the dehiscence), the goal-directed fluid, the multimodal opioid-sparing analgesia, and the postoperative nausea and vomiting.

medium40 referencesUpdated 17 Aug 202629 min readSource-verified · Sept 2026

Checked against its sources on 3 Sept 2026

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Red flags

  • The high-risk surgical patient needs HDU/ICU — the 12.5% of surgical patients who account for over 80% of perioperative deaths
  • Postoperative troponin rise is usually type 2 MI (MINS) — supply-demand mismatch — NOT plaque rupture; treat the trigger, not with immediate DAPT/anticoag
  • Anastomotic leak presents day 5-7 post-bowel surgery — fever, tachycardia, ileus — CT with contrast, surgical/radiological drainage; delay is harm
  • Postoperative AF peaks day 2-3 — rate control first; assess CHA2DS2-VASc before anticoagulation
  • Restrictive transfusion is standard in stable patients — TRICC trigger Hb under 70 g/L, maintained 70-90 g/L
  • POISE: routine perioperative beta-blockade causes MORE harm (stroke, death) than benefit — only continue already-started beta-blockers
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Practise this topic8 MCQs with explanations

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Red flags

  • The high-risk surgical patient needs HDU/ICU — the 12.5% of surgical patients who account for over 80% of perioperative deaths
  • Postoperative troponin rise is usually type 2 MI (MINS) — supply-demand mismatch — NOT plaque rupture; treat the trigger, not with immediate DAPT/anticoag
  • Anastomotic leak presents day 5-7 post-bowel surgery — fever, tachycardia, ileus — CT with contrast, surgical/radiological drainage; delay is harm
  • Postoperative AF peaks day 2-3 — rate control first; assess CHA2DS2-VASc before anticoagulation
  • Restrictive transfusion is standard in stable patients — TRICC trigger Hb under 70 g/L, maintained 70-90 g/L
  • POISE: routine perioperative beta-blockade causes MORE harm (stroke, death) than benefit — only continue already-started beta-blockers
The one-paragraph exam answer

Perioperative critical care is finding the high-risk surgical patient and wrapping a monitored pathway around them — most perioperative deaths are postoperative, not intraoperative.[12] Pre-op: cardiopulmonary exercise testing (an anaerobic threshold under 11 mL/kg/min flags high cardiovascular risk[15]), POSSUM and ACS-NSQIP scoring, then the four-pillar optimisation — smoking cessation (counselling plus nicotine replacement begun 6 to 8 weeks out in the landmark RCT, which halved complications — 18 versus 52 per cent),[7] anaemia correction,[18] glycaemic control, prehabilitation — and the stop-continue-bridge medication review (continue the beta-blocker and the statin, never newly start a beta-blocker — POISE[3]). Intra-op: an ERAS bundle[19] plus goal-directed therapy by stroke-vo…

Meet the patient

A 72-year-old man, ex-smoker, ASA 3, is booked for an open Ivor-Lewis oesophagectomy. He cannot climb a flight of stairs without stopping for breath. CPET returns an anaerobic threshold of 9.5 mL/kg/min — under the high-risk threshold of 11, and at the level that best predicts major perioperative cardiac complications in oesophageal and gastric cancer surgery.[15] ACS-NSQIP predicts a 14 per cent risk of serious complication — a patient-specific probability the calculator generates for exactly this shared decision.[8] He is exactly the patient the 80/12 rule is about — and exactly the patient who will derail on a general ward at 3am on day 2 if no one booked the HDU bed.[12]

Two questions frame everything that follows: which twelve-and-a-half per cent is he? (the high-risk group — 12.5 per cent of surgical procedures — in which more than 80 per cent of perioperative deaths concentrate[12]) and what do I change between now and the knife to stop him becoming a failure-to-rescue? Hold those two and the pathway below slots into place.[12]

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References40ShowHide
  1. [1]Copeland GP, Jones D, Walters M POSSUM: a scoring system for surgical audit Br J Surg, 1991.PMID 2021856
  2. [2]Pearse RM, Harrison DA, MacDonald N, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review JAMA, 2014.PMID 24842135
  3. [3]Devereaux PJ, Yang H, Yusuf S, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial Lancet, 2008.PMID 18479744
  4. [4]Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N Engl J Med, 1999.PMID 9971864
  5. [5]Devereaux PJ, Biccard BM, Sigamani A, et al. Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery JAMA, 2017.PMID 28444280
  6. [6]Older P, Smith R, Hall A, et al. Preoperative cardiopulmonary risk assessment by cardiopulmonary exercise testing Crit Care Resusc, 2000.PMID 16599898
  7. [7]Møller AM, Villebro N, Pedersen T, et al. Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial Lancet, 2002.PMID 11809253
  8. [8]Liu Y, Cohen ME, Hall BL, et al. Evaluation and Enhancement of Calibration in the American College of Surgeons NSQIP Surgical Risk Calculator J Am Coll Surg, 2016.PMID 27212006
  9. [9]Rigg JR, Jamrozik K, Myles PS, et al. Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial Lancet, 2002.PMID 11965272
  10. [10]Kheterpal S, Tremper KK, Heung M, et al. Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set Anesthesiology, 2009.PMID 19212261
  11. [11]Rüsch D, Eberhart L, Biedler A, et al. Prospective application of a simplified risk score to prevent postoperative nausea and vomiting Can J Anaesth, 2005.PMID 15872125
  12. [12]Pearse RM, Harrison DA, James P, et al. Identification and characterisation of the high-risk surgical population in the United Kingdom Crit Care, 2006.PMID 16749940
  13. [13]Li G, Warner M, Lang BH, et al. Epidemiology of anesthesia-related mortality in the United States, 1999-2005 Anesthesiology, 2009.PMID 19322941
  14. [14]Older P, Hall A, Hader R Cardiopulmonary exercise testing as a screening test for perioperative management of major surgery in the elderly Chest, 1999.PMID 10453862
  15. [15]Ozova M, Chomakhidze P, Poltavskaya M, et al. Cardiopulmonary exercise testing for cardiovascular risk assessment in patients undergoing gastric and oesophageal cancer surgery: results from a prospective interventional cohort study Open Heart, 2022.PMID 35840177
  16. [16]Brunelli A, Belardinelli R, Pompili C, et al. Minute ventilation-to-carbon dioxide output (VE/VCO2) slope is the strongest predictor of respiratory complications and death after pulmonary resection Ann Thorac Surg, 2012.PMID 22560968
  17. [17]Barker P, Creasey PE, Dhatariya K, et al. Peri-operative management of the surgical patient with diabetes 2015: Association of Anaesthetists of Great Britain and Ireland Anaesthesia, 2015.PMID 26417892
  18. [18]Mueller MM, Van Remoortel H, Meybohm P, et al. Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference JAMA, 2019.PMID 30860564
  19. [19]Gustafsson UO, Scott MJ, Hubner M, et al. Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations: 2018 World J Surg, 2019.PMID 30426190
  20. [20]Smith I, Kranke P, Murat I, et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology Eur J Anaesthesiol, 2011.PMID 21712716
  21. [21]Gustafsson UO, Hausel J, Thorell A, et al. Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery Arch Surg, 2011.PMID 21242424
  22. [22]Semler MW, Self WH, Wanderer JP, et al. Balanced Crystalloids versus Saline in Critically Ill Adults N Engl J Med, 2018.PMID 29485925
  23. [23]Self WH, Semler MW, Wanderer JP, et al. Balanced Crystalloids versus Saline in Noncritically Ill Adults N Engl J Med, 2018.PMID 29485926
  24. [24]Kurz A, Sessler DI, Lenhardt R, et al. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization N Engl J Med, 1996.PMID 8606715
  25. [25]Canet J, Gallart L, Gomar C, et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort Anesthesiology, 2010.PMID 21045639
  26. [26]Bergqvist D Low molecular weight heparin for the prevention of venous thromboembolism after abdominal surgery Br J Surg, 2004.PMID 15286956
  27. [27]Jaber S, Lescot T, Futier E, et al. Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery: A Randomized Clinical Trial JAMA, 2016.PMID 26975890
  28. [28]Liu D, Liang L, Liu L, Zhu Z Does intraoperative indocyanine green fluorescence angiography decrease the incidence of anastomotic leakage in colorectal surgery? A systematic review and meta-analysis Int J Colorectal Dis, 2021.PMID 32944782
  29. [29]Crippa J, Duchalais E, Machairas N, et al. Long-term Oncological Outcomes Following Anastomotic Leak in Rectal Cancer Surgery Dis Colon Rectum, 2020.PMID 32109914
  30. [30]Leng A, Perdomo D, Ha JS, et al. National Analysis of Anastomotic Leak and Subsequent Failure to Rescue After Esophagectomy J Surg Res, 2025.PMID 40669375
  31. [31]Gan TJ, Belani KG, Bergese S, et al. Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting Anesth Analg, 2020.PMID 32467512
  32. [32]Kienbaum P, Schaefer MS, Weibel S, et al. [Update on PONV-What is new in prophylaxis and treatment of postoperative nausea and vomiting? : Summary of recent consensus recommendations and Cochrane reviews on prophylaxis and treatment of postoperative nausea and vomiting]. Anaesthesist, 2022.PMID 34596699
  33. [33]Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists J Pain, 2016.PMID 26827847
  34. [34]Beverly A, Kaye AD, Ljungqvist O, Urman RD Essential Elements of Multimodal Analgesia in Enhanced Recovery After Surgery (ERAS) Guidelines Anesthesiol Clin, 2017.PMID 28526156
  35. [35]El-Boghdadly K, Dhesi J, Fabb P, et al. Elective peri-operative management of adults taking glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide agonists and sodium-glucose cotransporter-2 inhibitors: a multidisciplinary consensus statement Anaesthesia, 2025.PMID 39781571
  36. [36]Devlin JW, Skrobik Y, Gélinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Crit Care Med, 2018.PMID 30113379
  37. [37]Lewis K, Balas MC, Stollings JL, et al. A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU Crit Care Med, 2025.PMID 39982143
  38. [38]Noblett SE, Snowden CP, Shenton BK, Horgan AF Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection Br J Surg, 2006.PMID 16888706
  39. [39]Gillies MA, Harrison EM, Pearse RM, et al. Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study Br J Anaesth, 2017.PMID 28039249
  40. [40]Bhave PD, Goldman LE, Vittinghoff E, et al. Incidence, predictors, and outcomes associated with postoperative atrial fibrillation after major noncardiac surgery Am Heart J, 2012.PMID 23194493

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