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ICU TopicsCardiovascular / hypertension

ICU · Cardiovascular / hypertension

Hypertensive Emergencies

Also known as Hypertensive emergency · Hypertensive crisis · Hypertensive encephalopathy · Malignant hypertension · Hypertensive urgency · Labetalol · Nicardipine · Nitroprusside · Posterior reversible encephalopathy syndrome · PRES

A hypertensive emergency is severe blood pressure elevation with acute target-organ damage (encephalopathy, stroke, intracerebral haemorrhage, ACS, pulmonary oedema, aortic dissection, acute kidney injury, or eclampsia) — it requires IV therapy and ICU monitoring. A hypertensive urgency is severe BP without target-organ damage — it requires oral therapy and follow-up. The principle is a controlled, monitored BP reduction: lower the MAP by 10-20 per cent in the first hour, then to 160/100 within 2-6 hours, then gradually to baseline. Do NOT crash the BP — the chronic hypertensive's autoregulation curve is shifted right, and a sudden reduction causes cerebral, coronary, and renal hypoperfusion. The exceptions are aortic dissection (rapid to SBP 100-120) and eclampsia (SBP below 160). The drugs: labetalol, nicardipine, nitroprusside, GTN, and hydralazine.

high11 referencesUpdated 19 Aug 202623 min readVerification in progress

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A hypertensive emergency is severe blood pressure with acute target-organ damage — it needs intravenous therapy and ICU monitoring; a hypertensive urgency is severe blood pressure without damage and gets oral therapy. Lower the MAP by 10 to 20 per cent in the first hour, then to about 160/100 over 2 to 6 hours, and never crash the BP — the chronic hypertensive's autoregulation is shifted right, and a sudden drop causes cerebral, coronary and renal hypoperfusion. The exceptions are aortic dissection (rapid to SBP 100 to 120, beta-blocker first), intracerebral haemorrhage (SBP to 140), and eclampsia (magnesium first).[1][2]

Meet the patient

A 52-year-old man with ten years of untreated hypertension arrives with a day of throbbing headache, blurred vision and two seizures in the ambulance. He is post-ictal, GCS 13, BP 224/138 by arterial line, fundoscopy shows papilloedema and flame haemorrhages, and his creatinine has jumped from 95 to 186 with schistocytes on the film. The number is dramatic — but it is the brain, the retina and the kidney that make this an emergency, not the 224.[1]

Two questions decide his first hour. Is there target-organ damage? (the BP number alone never decides it). And which specific organ is failing? — because the drug and the BP target follow the organ, not the habit of the unit.[2]

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References11ShowHide
  1. [1]Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines J Am Coll Cardiol, 2018.PMID 29146535
  2. [2]van den Born BH, Lip GYH, Brguljan-Hitij J, et al. ESC Council on hypertension position document on the management of hypertensive emergencies Eur Heart J Cardiovasc Pharmacother, 2019.PMID 30165588
  3. [3]Perez MI, Musini VM Pharmacological interventions for hypertensive emergencies Cochrane Database Syst Rev, 2008.PMID 18254026
  4. [4]Immink RV, van den Born BJ, van Montfrans GA, Koopmans RP, Karemaker JM, van Lieshout JJ. Impaired cerebral autoregulation in patients with malignant hypertension Circulation, 2004.PMID 15466625
  5. [5]Anderson CS, Heeley E, Huang Y, et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage N Engl J Med, 2013.PMID 23713578
  6. [6]Qureshi AI, Palesch YY, Barsan WG, et al. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage N Engl J Med, 2016.PMID 27276234
  7. [7]Katz JN, Gore JM, Amin A, et al. Practice patterns, outcomes, and end-organ dysfunction for patients with acute severe hypertension: the Studying the Treatment of Acute hyperTension (STAT) registry Am Heart J, 2009.PMID 19781420
  8. [8]Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial Lancet, 2002.PMID 12057549
  9. [9]Aronson S, Dyke C, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients Anesth Analg, 2008.PMID 18806012
  10. [10]S D, Novri DA, Hamidy Y, Savira M. Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial F1000Research, 2022.PMID 37273965
  11. [11]Bress AP, Anderson TS, Flack JM, et al. The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association Hypertension, 2024.PMID 38804130

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