ICU · Cardiovascular / hypertension
Hypertensive Emergencies
Also known as Hypertensive emergency · Hypertensive crisis · Hypertensive encephalopathy · Malignant hypertension · Hypertensive urgency · Labetalol · Nicardipine · Nitroprusside · Posterior reversible encephalopathy syndrome · PRES
A hypertensive emergency is severe blood pressure elevation with acute target-organ damage (encephalopathy, stroke, intracerebral haemorrhage, ACS, pulmonary oedema, aortic dissection, acute kidney injury, or eclampsia) — it requires IV therapy and ICU monitoring. A hypertensive urgency is severe BP without target-organ damage — it requires oral therapy and follow-up. The principle is a controlled, monitored BP reduction: lower the MAP by 10-20 per cent in the first hour, then to 160/100 within 2-6 hours, then gradually to baseline. Do NOT crash the BP — the chronic hypertensive's autoregulation curve is shifted right, and a sudden reduction causes cerebral, coronary, and renal hypoperfusion. The exceptions are aortic dissection (rapid to SBP 100-120) and eclampsia (SBP below 160). The drugs: labetalol, nicardipine, nitroprusside, GTN, and hydralazine.
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A 52-year-old man with ten years of untreated hypertension arrives with a day of throbbing headache, blurred vision and two seizures in the ambulance. He is post-ictal, GCS 13, BP 224/138 by arterial line, fundoscopy shows papilloedema and flame haemorrhages, and his creatinine has jumped from 95 to 186 with schistocytes on the film. The number is dramatic — but it is the brain, the retina and the kidney that make this an emergency, not the 224.[1]
Two questions decide his first hour. Is there target-organ damage? (the BP number alone never decides it). And which specific organ is failing? — because the drug and the BP target follow the organ, not the habit of the unit.[2]
References11ShowHide
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- [2]van den Born BH, Lip GYH, Brguljan-Hitij J, et al. ESC Council on hypertension position document on the management of hypertensive emergencies Eur Heart J Cardiovasc Pharmacother, 2019.PMID 30165588
- [3]Perez MI, Musini VM Pharmacological interventions for hypertensive emergencies Cochrane Database Syst Rev, 2008.PMID 18254026
- [4]Immink RV, van den Born BJ, van Montfrans GA, Koopmans RP, Karemaker JM, van Lieshout JJ. Impaired cerebral autoregulation in patients with malignant hypertension Circulation, 2004.PMID 15466625
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- [7]Katz JN, Gore JM, Amin A, et al. Practice patterns, outcomes, and end-organ dysfunction for patients with acute severe hypertension: the Studying the Treatment of Acute hyperTension (STAT) registry Am Heart J, 2009.PMID 19781420
- [8]Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial Lancet, 2002.PMID 12057549
- [9]Aronson S, Dyke C, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients Anesth Analg, 2008.PMID 18806012
- [10]S D, Novri DA, Hamidy Y, Savira M. Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial F1000Research, 2022.PMID 37273965
- [11]Bress AP, Anderson TS, Flack JM, et al. The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association Hypertension, 2024.PMID 38804130