ICU · Cardiovascular / cardiomyopathy
Cardiomyopathies & Myocarditis
Also known as Cardiomyopathy · Dilated cardiomyopathy · Hypertrophic cardiomyopathy · Restrictive cardiomyopathy · Arrhythmogenic right ventricular cardiomyopathy · ARVC · Takotsubo cardiomyopathy · Stress cardiomyopathy · Broken heart syndrome · Myocarditis · Giant cell myocarditis · Eosinophilic myocarditis · Fulminant myocarditis · Cardiac amyloidosis · SAM · Systolic anterior motion · LVOT obstruction · Mavacamten · Tafamidis · Cardiac MRI late gadolinium enhancement · Lake Louise criteria · Dallas criteria · HCM Risk-SCD
The four cardiomyopathies are dilated (the commonest — an enlarged LV with a reduced EF, treated with heart-failure therapy), hypertrophic (asymmetric septal LVH with a dynamic LVOT obstruction and a risk of sudden cardiac death — treat with beta-blockers, avoid vasodilators, an ICD for prevention), restrictive (amyloid, sarcoid — stiff ventricles with impaired filling, treated for the cause), and arrhythmogenic (a genetic right-ventricular cardiomyopathy). Takotsubo is a transient stress-mediated apical ballooning that mimics an anterior STEMI. Myocarditis is an inflammation of the myocardium (most commonly viral — coxsackie, parvovirus, SARS-CoV-2), presenting with chest pain, arrhythmia, heart failure, and a rising troponin with normal coronary arteries. The cardiac MRI (mid-wall late gadolinium enhancement) and the biopsy (the Dallas criteria) confirm. Treatment is supportive; most recover, but giant-cell and a fulminant case may need immunosuppression, mechanical support or a transplant.
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Red flags
- In HCM never give a vasodilator, a diuretic, or an inotrope — they worsen the dynamic LVOT obstruction; use a beta-blocker and a pure alpha-vasopressor (phenylephrine)
- Myocarditis mimics an ACS — a rising troponin with normal coronaries; the MRI mid-wall LGE distinguishes it from the subendocardial LGE of an infarct; do not thrombolyse or stent a myocarditis
- Giant cell myocarditis is universally fatal without immunosuppression (cyclosporine/steroids) and/or transplant — biopsy any fulminant case in a middle-aged adult
- Fulminant myocarditis may need mechanical support (VA-ECMO, Impella) or a transplant as a bridge to recovery — and paradoxically has a BETTER long-term prognosis than non-fulminant acute myocarditis
- Restriction vs constriction — the pericardium is the key: restriction has a normal pericardium and a thick infiltrated LV (treat medically); constriction has a thickened pericardium and a normal LV (pericardiectomy)
- Takotsubo can cause LVOT obstruction, ventricular thrombus, free-wall rupture and Torsades — anticoagulate if apical thrombus, avoid inotropes if LVOT obstruction
- Cardiac amyloidosis — never give ACE inhibitors/ARBs or calcium-channel blockers (the 'doubleGamma sign' of intolerance); avoid digoxin (binds amyloid fibrils)
Overview & definition
The cardiomyopathies are diseases of the heart muscle, classified into four morphological types — dilated (the commonest), hypertrophic, restrictive, and arrhythmogenic right ventricular — to which Takotsubo (stress) cardiomyopathy is often added as a fifth, reversible, mimic. Myocarditis is an inflammation of the myocardium (most commonly viral) that can mimic an ACS and may progress to a dilated cardiomyopathy.[1]
The 2023 ESC cardiomyopathy guideline reframes these around a phenotype-first, genotype-driven approach: define the phenotype (dilated, hypertrophic, restrictive, non-compaction, ARVC) from imaging, then hunt systematically for the cause (genetic, acquired), and cascade-screen first-degree relatives.[1]
References20ShowHide
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