ICU · Monitoring / haemodynamics
Advanced Haemodynamic Monitoring — PA Catheter, PiCCO & Pulse Contour
Also known as Advanced haemodynamic monitoring · Pulmonary artery catheter · PAC · Swan-Ganz · PiCCO · Transpulmonary thermodilution · Pulse contour analysis · FloTrac · Vigileo · LiDCO · Esophageal Doppler · Extravascular lung water · EVLW · GEDI · ITBI · Mixed venous oxygen saturation · SvO2 · LVOT VTI
Advanced haemodynamic monitoring measures the cardiac output and related variables beyond the basic arterial and CVP lines. The pulmonary artery catheter (PAC, Swan-Ganz) is the gold standard — it directly measures the PAWP (left atrial pressure), the SvO2 (oxygen balance), and the CO by thermodilution, but its routine use has declined after the FACTT trial (no benefit over central-line-guided therapy); it is now reserved for complex shock, pulmonary hypertension, and RV failure. The PiCCO (transpulmonary thermodilution) provides the CO, the GEDV (preload), the EVLW (lung water), and a calibrated continuous pulse-contour CO and SVV. Uncalibrated pulse contour devices (FloTrac/Vigileo) use an arterial line alone and are less accurate; LiDCO (lithium dilution) is a calibrated alternative needing only a radial line; esophageal Doppler gives continuous CO from the descending aorta. Echocardiography (LVOT VTI) is the leading non-invasive alternative. The choice depends on the clinical question: filling pressure (PAWP), volume (GEDV), responsiveness (SVV/PPV), or oxygen balance (SvO2).
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- PAC has no proven mortality benefit (PAC-Man, ESCAPE, FACTT) — use selectively for complex shock, pulmonary HTN, RV failure, MCS titration, never routinely
- Pulmonary artery rupture is rare but fatal — presents as catastrophic haemoptysis; risk factors anticoagulation, age, female, pulmonary HTN, distal wedge
- PAC + pre-existing LBBB risks complete heart block (transient RBBB during RV transit) — have pacing available
- SVV/PPV are INVALID in atrial fibrillation, spontaneous breathing, low tidal volume ventilation, right heart failure, and open chest
- Uncalibrated pulse contour (FloTrac/Vigileo) loses accuracy when vascular tone changes (vasopressors, sepsis) — use for trends, recalibrate after major changes
- EVLW (extravascular lung water) predicts mortality and guides fluid strategy — a low or falling EVLW is the target in ARDS/septic shock
- CVP is a POOR predictor of fluid responsiveness (AUC ~0.56, Marik 2013) — do NOT use alone to guide fluid therapy
Meet the patient
A 58-year-old man is in septic shock from a urinary source. He has had 30 mL/kg of crystalloid, noradrenaline is climbing to 0.3 mcg/kg/min, the lactate is 4.2 and the focused echo shows a small, hyperdynamic LV with kissing walls. The registrar reaches for the PA catheter "to optimise resuscitation" — a reflex the evidence does not support: the PAC should not be used in most critically ill patients.[1]
The two questions that settle the next hour are the two that settle every haemodynamic problem: which question am I actually trying to answer — filling pressure, volume, responsiveness, oxygen balance, lung water — and which is the least invasive monitor that answers it. Hold those two and the device menagerie below slots into place.[7][10]
References21ShowHide
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- [2]Connors AF Jr, Speroff T, Dawson NV, et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators JAMA, 1996.PMID 8782638
- [3]Binanay C, Califf RM, Hasselblad V, et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial JAMA, 2005.PMID 16204662
- [4]Harvey S, Harrison DA, Singer M, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial Lancet, 2005.PMID 16084255
- [5]Wheeler AP, Bernard GR, Thompson BT, et al. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury N Engl J Med, 2006.PMID 16714768
- [6]Marik PE, Cavallazzi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense Crit Care Med, 2013.PMID 23774337
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- [8]Sakka SG, Klein M, Reinhart K, Meier-Hellmann A. Prognostic value of extravascular lung water in critically ill patients Chest, 2002.PMID 12475851
- [9]Pearse RM, Harrison DA, MacDonald N, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review JAMA, 2014.PMID 24842135
- [10]Pinsky MR, Cecconi M, Chew MS, et al. Effective hemodynamic monitoring Crit Care, 2022.PMID 36171594
- [11]Marik PE, Cavallazzi R, Vasu T, Hirani A. Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature Crit Care Med, 2009.PMID 19602972
- [12]Monnet X, Marik P, Teboul JL. Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis Intensive Care Med, 2016.PMID 26825952
- [13]Monnet X, Teboul JL. Transpulmonary thermodilution: advantages and limits Crit Care, 2017.PMID 28625165
- [14]Messina A, Alicino V, Cecconi M. Transpulmonary thermodilution Curr Opin Crit Care, 2023.PMID 37083621
- [15]Linton RA, Band DM, Haire KM. A new method of measuring cardiac output in man using lithium dilution Br J Anaesth, 1993.PMID 8123404
- [16]Del Rio-Pertuz G, Nugent K, Argueta-Sosa E. Right heart catheterization in clinical practice: a review of basic physiology and important issues relevant to interpretation Am J Cardiovasc Dis, 2023.PMID 37469534
- [17]De Backer D, Heenen S, Piagnerelli M, Koch M, Vincent JL. Pulse pressure variations to predict fluid responsiveness: influence of tidal volume Intensive Care Med, 2005.PMID 15754196
- [18]Sakka SG, Rühl CC, Pfeiffer UJ, Beale R, McLuckie A, Reinhart K, Meier-Hellmann A. Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution Intensive Care Med, 2000.PMID 10784306
- [19]Alvarado-Sánchez JI, Caicedo-Ruiz JD, Torres-Martínez MJ, Diaztagle-Fernández JJ. Fluid responsiveness in ARDS: current evidence, knowledge gaps, and future directions - a scoping review of the literature BMC Anesthesiol, 2026.PMID 42143226
- [20]Kurita T, Morita K, Kato S, et al. Lithium dilution cardiac output measurements using a peripheral injection site comparison with central injection technique and thermodilution J Clin Monit Comput, 1999.PMID 12568133
- [21]Belda FJ, Aguilar G, Teboul JL, et al. Complications related to less-invasive haemodynamic monitoring Br J Anaesth, 2011.PMID 21205627