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ICU TopicsCardiovascular

ICU · Cardiovascular

Acute decompensated heart failure and cardiogenic pulmonary oedema

Also known as Acute decompensated heart failure (ADHF) · Cardiogenic pulmonary oedema · Flash pulmonary oedema · Acute heart failure (AHF)

Acute decompensated heart failure (ADHF) is a life-threatening syndrome of pulmonary and/or systemic congestion from cardiac dysfunction. Presentations: cardiogenic pulmonary oedema (acute breathlessness, orthopnoea, frothy sputum, bilateral crackles, hypoxia), cardiogenic shock (hypoperfusion — cold extremities, oliguria, altered mental status), or isolated right heart failure (peripheral oedema, raised JVP, hepatomegaly). Management: sit upright, high-flow oxygen, IV furosemide (1-2.5x usual oral dose), vasodilator (nitroglycerin if SBP 110), non-invasive ventilation (CPAP/BiPAP — reduces intubation and mortality). Identify and treat precipitant (ACS, arrhythmia, infection, non-adherence). Avoid beta-blockers acutely (negative inotropy).

high27 referencesUpdated 26 July 202610 min readVerification in progress

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Red flags

  • CPAP/BiPAP reduces mortality and intubation rates in cardiogenic pulmonary oedema — use EARLY
  • Do NOT give beta-blockers in acute decompensated HF (negative inotropy) — may precipitate cardiogenic shock
  • SBP <90 with pulmonary oedema = cardiogenic shock — different pathway (inotropes, mechanical support)
  • Flash pulmonary oedema = consider bilateral renal artery stenosis (especially if AKI after ACE inhibitor)
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Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • CPAP/BiPAP reduces mortality and intubation rates in cardiogenic pulmonary oedema — use EARLY
  • Do NOT give beta-blockers in acute decompensated HF (negative inotropy) — may precipitate cardiogenic shock
  • SBP <90 with pulmonary oedema = cardiogenic shock — different pathway (inotropes, mechanical support)
  • Flash pulmonary oedema = consider bilateral renal artery stenosis (especially if AKI after ACE inhibitor)
The one-line answer

Acute decompensated heart failure is a vicious cycle of congestion and neurohormonal activation that you break at the bedside with four moves: sit upright, high-flow oxygen, IV furosemide at 1 to 2.5 times the usual oral dose, and CPAP or BiPAP early — the one acute intervention with a mortality signal. Add a vasodilator (nitroglycerin) only if the systolic is over 110, never give a beta-blocker acutely (negative inotropy), and switch to the shock pathway (inotropes, mechanical support) moment systolic drops under 90. The Stevenson profile — warm or cold, wet or dry — decides the pathway in thirty seconds. Then find and treat the precipitant, because decongestion without addressing the trigger just sends the patient back.[1]

Meet the patient

A 72-year-old man with known HFrEF (ejection fraction 30 percent) on bisoprolol, ramipril, spironolactone, and furosemide 80 mg daily is brought in at 4am sitting bolt upright, gasping, pink frothy sputum at his lips. His rate is 34, SpO2 84 percent on room air, BP 168 over 95, and he is in fast atrial fibrillation at 116. Bilateral coarse crackles rise to the apices, the JVP is at the angle of the jaw, and the chest X-ray shows bat-wing perihilar infiltrates with Kerley B lines.[1]

The two questions that decide his next hour are the two that decide every ADHF stem: is he perfused or shocky? (warm versus cold decides whether you reach for diuretics or for inotropes) and what tipped him over? (ACS, new AF, infection, non-adherence — the trigger you must find and fix). Hold those two questions and the Stevenson profile slots everything into place.[1]

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References27ShowHide
  1. [1]McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Eur Heart J, 2021.PMID 34447992
  2. [2]Vital FMR, Ladeira MT, Atallah AN. Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema Cochrane Database Syst Rev, 2013.PMID 23728654
  3. [3]Chioncel O, Mebazaa A, Harjola VP, et al. Acute heart failure congestion and perfusion status - impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP-HFA Heart Failure Long-Term Registry Eur J Heart Fail, 2019.PMID 31127678
  4. [4]Seferovic PM, Ponikowski P, Anker SD, et al. Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail, 2019.PMID 31129923
  5. [5]Nohria A, Tsang SW, Fang JC, et al. Clinical assessment identifies hemodynamic profiles that predict outcomes in patients admitted with heart failure J Am Coll Cardiol, 2003.PMID 12767667
  6. [6]Felker GM, Lee KL, Bull DA, et al. Diuretic strategies in patients with acute decompensated heart failure N Engl J Med, 2011.PMID 21366472
  7. [7]Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J (3CPO Trialists). Noninvasive ventilation in acute cardiogenic pulmonary edema N Engl J Med, 2008.PMID 18614781
  8. [8]Chen HH, Anstrom KJ, Givertz MM, et al. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial JAMA, 2013.PMID 24247300
  9. [9]Bart BA, Goldsmith SR, Lee KL, et al. Ultrafiltration in decompensated heart failure with cardiorenal syndrome N Engl J Med, 2012.PMID 23131078
  10. [10]Teerlink JR, Cotter G, Davison BA, et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial Lancet, 2013.PMID 23141816
  11. [11]McMurray JJ, Teerlink JR, Cotter G, et al. Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials JAMA, 2007.PMID 17986694
  12. [12]Mebazaa A, Nieminen MS, Packer M, et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial JAMA, 2007.PMID 17473298
  13. [13]O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure N Engl J Med, 2011.PMID 21732835
  14. [14]Costanzo MR, Guglin ME, Saltzberg MT, et al. Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure J Am Coll Cardiol, 2007.PMID 17291932
  15. [15]Thiele H, Zeymer U, Neumann FJ, et al. Intraaortic balloon support for myocardial infarction with cardiogenic shock N Engl J Med, 2012.PMID 22920912
  16. [16]Thiele H, Akin I, Sandri M, et al. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock N Engl J Med, 2017.PMID 29083953
  17. [17]Cuffe MS, Califf RM, Adams KF Jr, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial JAMA, 2002.PMID 11911756
  18. [18]McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction N Engl J Med, 2019.PMID 31535829
  19. [19]Mebazaa A, Davison B, Chioncel O, et al. Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial Lancet, 2022.PMID 36356631
  20. [20]Scheeren TWL, Bakker J, Kaufmann T, et al. Current use of inotropes in circulatory shock Ann Intensive Care, 2021.PMID 33512597
  21. [21]Srivastava M, Harrison N, Caetano AFS, et al. Ultrafiltration for acute heart failure Cochrane Database Syst Rev, 2022.PMID 35061249
  22. [22]Metra M, Teerlink JR, Cotter G, et al. Effects of Serelaxin in Patients with Acute Heart Failure N Engl J Med, 2019.PMID 31433919
  23. [23]Mullens W, Dauw J, Martens P, et al. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload N Engl J Med, 2022.PMID 36027559
  24. [24]Mullens W, Damman K, Harjola VP, et al. The use of diuretics in heart failure with congestion - a position statement from the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail, 2019.PMID 30600580
  25. [25]Cotter G, Metzkor E, Kaluski E, et al. Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema Lancet, 1998.PMID 9482291
  26. [26]Sharon A, Shpirer I, Kaluski E, et al. High-dose intravenous isosorbide-dinitrate is safer and better than Bi-PAP ventilation combined with conventional treatment for severe pulmonary edema J Am Coll Cardiol, 2000.PMID 10987607
  27. [27]McMurray JJ, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure N Engl J Med, 2014.PMID 25176015

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