ICU · Cardiovascular / aortic
Acute Aortic Syndromes — Dissection
Also known as Acute aortic syndrome · Aortic dissection · Stanford classification · Type A dissection · Type B dissection · Intimal flap · TEVAR · Malperfusion
Acute aortic dissection is classified by the Stanford system: Type A (involving the ascending aorta — a surgical emergency with a high risk of rupture, tamponade, aortic regurgitation, and stroke) and Type B (descending aorta, distal to the left subclavian — managed medically with aggressive BP control). The classic presentation is a tearing chest or back pain, maximal at onset, with a pulse deficit or a new aortic regurgitation murmur. The diagnosis is by CT angiography (the intimal flap, the true and the false lumen). Type A requires urgent surgery; Type B is managed with a beta-blocker FIRST (to control the heart rate and the sheer stress), then a vasodilator (to lower the BP to an SBP under 120). Never give a vasodilator without a beta-blocker first — the reflex tachycardia worsens the dissection.
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Meet the patient
A 64-year-old hypertensive man arrives at 6am with tearing chest pain that struck "like a clap of thunder" the moment it began, radiating straight through to his back between the shoulder blades. His right arm blood pressure is 184/102; his left is 150/96. There is a new early diastolic murmur down the left sternal edge. The ECG shows sinus tachycardia and nothing else.[6]
Two questions decide his next hour. Is the ascending aorta involved? (the CT aortogram answers in minutes — and if yes, the patient belongs in theatre now). And in either case, what drug goes in first? The answer to that second question is the single most tested point in the fellowship exam: the beta-blocker, always before the vasodilator.[1]
References16ShowHide
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- [2]Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC) Eur Heart J, 2014.PMID 25173340
- [3]Nienaber CA, Kische S, Rousseau H, et al. Endovascular repair of type B aortic dissection: long-term results of the randomized investigation of stent grafts in aortic dissection trial Circ Cardiovasc Interv, 2013.PMID 23922146
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- [8]Liu G, Wang D, Yang Y, et al. Efficacy and Safety of preoperative Controlling Heart Rate in Patients with Acute Type A Aortic Dissection (ESCORT): protocol for a randomised controlled trial BMJ Open, 2026.PMID 41962972
- [9]Krenz JR, O'Brien ME, Lee J, Hayes BD. Evaluation of esmolol for heart rate control in patients with acute aortic dissection Am J Emerg Med, 2021.PMID 32354528
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- [11]Saricilar EC, Budtz-Lilly J, Biersteker B, et al. SUNDAY trial insights: questionnaire of clinical perspectives on medical therapy in uncomplicated type B aortic dissections J Cardiovasc Surg (Torino), 2025.PMID 40956597
- [12]Chen N, Downing JV, Epstein J, et al. Emergency Department Blood Pressure Management in Type B Aortic Dissection: An Analysis with Machine Learning West J Emerg Med, 2025.PMID 40561988
- [13]Nakamura G, Kato T, Inoue K, et al. Pericardial-Drain-to-Central-Venous-Line Return to Rescue Venoarterial Extracorporeal Membrane Oxygenation Flow in Tamponade From Stanford Type A Dissection: A Case Report Cureus, 2026.PMID 41769534
- [14]Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease JAMA, 2000.PMID 10685714
- [15]Kicska GA, Hurwitz Koweek LM, Ghoshhajra BB, et al. ACR Appropriateness Criteria® Suspected Acute Aortic Syndrome J Am Coll Radiol, 2021.PMID 34794601
- [16]Modares M, Hanneman K, Ouzounian M, et al. Computed Tomography Angiography Assessment of Acute Aortic Syndromes: Classification, Differentiating Imaging Features, and Imaging Interpretation Pitfalls Can Assoc Radiol J, 2022.PMID 33874779