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ICU TopicsCardiovascular / aortic

ICU · Cardiovascular / aortic

Acute Aortic Syndromes — Dissection

Also known as Acute aortic syndrome · Aortic dissection · Stanford classification · Type A dissection · Type B dissection · Intimal flap · TEVAR · Malperfusion

Acute aortic dissection is classified by the Stanford system: Type A (involving the ascending aorta — a surgical emergency with a high risk of rupture, tamponade, aortic regurgitation, and stroke) and Type B (descending aorta, distal to the left subclavian — managed medically with aggressive BP control). The classic presentation is a tearing chest or back pain, maximal at onset, with a pulse deficit or a new aortic regurgitation murmur. The diagnosis is by CT angiography (the intimal flap, the true and the false lumen). Type A requires urgent surgery; Type B is managed with a beta-blocker FIRST (to control the heart rate and the sheer stress), then a vasodilator (to lower the BP to an SBP under 120). Never give a vasodilator without a beta-blocker first — the reflex tachycardia worsens the dissection.

high16 referencesUpdated 20 Aug 202611 min readVerification in progress

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The one-line answer

Acute aortic dissection is a tear in the intima that admits blood into the media, splitting the aortic wall into a true and a false lumen. The Stanford system decides everything: Type A (any involvement of the ascending aorta) is a surgical emergency — mortality 1 to 2 per cent per hour untreated. Type B (descending aorta, distal to the left subclavian) is managed medically — a beta-blocker first (esmolol or labetalol, target heart rate under 60), then a vasodilator (nicardipine or nitroprusside, target SBP under 120 mmHg). Never a vasodilator alone — the reflex tachycardia increases shear and extends the flap. Complicated Type B (rupture, malperfusion, refractory pain) goes to TEVAR.[1][7][12][15]

Meet the patient

A 64-year-old hypertensive man arrives at 6am with tearing chest pain that struck "like a clap of thunder" the moment it began, radiating straight through to his back between the shoulder blades. His right arm blood pressure is 184/102; his left is 150/96. There is a new early diastolic murmur down the left sternal edge. The ECG shows sinus tachycardia and nothing else.[6]

Two questions decide his next hour. Is the ascending aorta involved? (the CT aortogram answers in minutes — and if yes, the patient belongs in theatre now). And in either case, what drug goes in first? The answer to that second question is the single most tested point in the fellowship exam: the beta-blocker, always before the vasodilator.[1]

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References16ShowHide
  1. [1]Isselbacher EM, Preventza O, Hamilton Black Iii J, et al. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines Circulation, 2022.PMID 36322642
  2. [2]Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC) Eur Heart J, 2014.PMID 25173340
  3. [3]Nienaber CA, Kische S, Rousseau H, et al. Endovascular repair of type B aortic dissection: long-term results of the randomized investigation of stent grafts in aortic dissection trial Circ Cardiovasc Interv, 2013.PMID 23922146
  4. [4]Brunkwall J, Kasprzak P, Verhoeven E, et al. Endovascular repair of acute uncomplicated aortic type B dissection promotes aortic remodelling: 1 year results of the ADSORB trial Eur J Vasc Endovasc Surg, 2014.PMID 24962744
  5. [5]Zhu Y, Lingala B, Baiocchi M, et al. Type A Aortic Dissection-Experience Over 5 Decades: JACC Historical Breakthroughs in Perspective J Am Coll Cardiol, 2020.PMID 33004136
  6. [6]Golledge J, Eagle KA. Acute aortic dissection Lancet, 2008.PMID 18603160
  7. [7]Elliott WJ. Clinical features in the management of selected hypertensive emergencies Prog Cardiovasc Dis, 2006.PMID 16627047
  8. [8]Liu G, Wang D, Yang Y, et al. Efficacy and Safety of preoperative Controlling Heart Rate in Patients with Acute Type A Aortic Dissection (ESCORT): protocol for a randomised controlled trial BMJ Open, 2026.PMID 41962972
  9. [9]Krenz JR, O'Brien ME, Lee J, Hayes BD. Evaluation of esmolol for heart rate control in patients with acute aortic dissection Am J Emerg Med, 2021.PMID 32354528
  10. [10]Ulici A, Jancik J, Lam TS, et al. Clevidipine versus sodium nitroprusside in acute aortic dissection: A retrospective chart review Am J Emerg Med, 2017.PMID 28669696
  11. [11]Saricilar EC, Budtz-Lilly J, Biersteker B, et al. SUNDAY trial insights: questionnaire of clinical perspectives on medical therapy in uncomplicated type B aortic dissections J Cardiovasc Surg (Torino), 2025.PMID 40956597
  12. [12]Chen N, Downing JV, Epstein J, et al. Emergency Department Blood Pressure Management in Type B Aortic Dissection: An Analysis with Machine Learning West J Emerg Med, 2025.PMID 40561988
  13. [13]Nakamura G, Kato T, Inoue K, et al. Pericardial-Drain-to-Central-Venous-Line Return to Rescue Venoarterial Extracorporeal Membrane Oxygenation Flow in Tamponade From Stanford Type A Dissection: A Case Report Cureus, 2026.PMID 41769534
  14. [14]Hagan PG, Nienaber CA, Isselbacher EM, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease JAMA, 2000.PMID 10685714
  15. [15]Kicska GA, Hurwitz Koweek LM, Ghoshhajra BB, et al. ACR Appropriateness Criteria® Suspected Acute Aortic Syndrome J Am Coll Radiol, 2021.PMID 34794601
  16. [16]Modares M, Hanneman K, Ouzounian M, et al. Computed Tomography Angiography Assessment of Acute Aortic Syndromes: Classification, Differentiating Imaging Features, and Imaging Interpretation Pitfalls Can Assoc Radiol J, 2022.PMID 33874779

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