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ICU TopicsBurns

ICU · Burns

Burn Wound Care & Infection

Also known as Burn wound management · Burn infection · Burn wound sepsis · Silver sulfadiazine · Early excision and grafting · Acticoat · Biobrane · Integra · ABA burn sepsis criteria

Burn wound care and infection — cleaning/debridement, topical antimicrobials (silver sulfadiazine, mafenide, silver nitrate, nanocrystalline silver), dressings and skin substitutes (Biobrane, dermal regeneration templates), early excision and grafting. Infection (colonisation to invasion; Gram-positive early, Gram-negatives later, fungal late). Burn patients have SIRS at baseline — sepsis is recognised with the modified ABA 2007 criteria (temperature, progressive tachycardia and tachypnoea, thrombocytopenia, insulin resistance, feeding intolerance — a trigger for concern, not a SIRS count). Burn wound sepsis remains a leading cause of death in severe burns. Continuous prophylactic systemic antibiotics are NOT recommended (weak evidence, resistance cost) — prevention rests on topical antimicrobials plus early excision plus infection control.

medium24 referencesUpdated 20 Aug 202614 min readVerification in progress

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The one-line answer

Burn wound care is cleaning and debridement, a topical antimicrobial (silver sulfadiazine, mafenide, or a silver-containing dressing), a dressing or skin substitute (Biobrane, a dermal regeneration template), and early excision and grafting — which substantially decreased invasive burn wound infection and secondary sepsis in modern burn care. Infection follows a predictable temporal drift: Gram-positive organisms early, Gram-negatives including Pseudomonas later in the stay, and fungal invasion late. Because burn patients have SIRS at baseline by definition, sepsis is recognised with the ABA 2007 trigger criteria — a change from the patient's own baseline plus evidence of infection, not a SIRS count. Continuous prophylactic systemic antibiotics are not recommended — prevention rests on topical antimicrobials plus early excision plus infection control.[1][2]

Meet the patient

A 50-year-old man is on day 6 of admission for a 45 per cent TBSA flame burn. He was extubated on day 3, is enterally fed, and had tangential excision with split-thickness skin grafting to the anterior torso on day 4. His documented baseline since day 3 is heart rate 104, respiratory rate 22, temperature 38.2 degrees C, platelets 320 and rising, glucose 8.5 on a sliding scale. This morning: heart rate 122, respiratory rate 28, temperature 39.4, platelets 95, glucose 14 despite unchanged insulin, and he is mildly confused. The grafted abdomen shows a 4 cm patch of dark, haemorrhagic discolouration with premature separation at the graft edge.[1]

Two facts make this sepsis, not baseline. Every abnormal number on its own is normal for a major burn — but together they are a change from his own documented baseline, and the dark haemorrhagic patch on the graft is a wound that is changing. That combination is the American Burn Association trigger for burn sepsis, and it is the single hardest call to make on the burns unit.[3]

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References24ShowHide
  1. [1]Church D, Elsayed S, Reid O, et al. Burn wound infections. Clin Microbiol Rev, 2006.PMID 16614255
  2. [2]Greenhalgh DG, Saffle JR, Holmes JH 4th, et al. American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res, 2007.PMID 17925660
  3. [3]Hogan BK, Wolf SE, Hospenthal DR, et al. Correlation of American Burn Association sepsis criteria with the presence of bacteremia in burned patients admitted to the intensive care unit. J Burn Care Res, 2012.PMID 22210056
  4. [4]Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016.PMID 26903338
  5. [5]Monafo WW Current treatment recommendations for topical burn therapy. Drugs, 1990.PMID 2226220
  6. [6]Fuller FW The side effects of silver sulfadiazine. J Burn Care Res, 2009.PMID 19349889
  7. [7]Gamelli RL, Paxton TP, O'Reilly M Bone marrow toxicity by silver sulfadiazine. Surg Gynecol Obstet, 1993.PMID 8342089
  8. [8]Klasen HJ A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns, 2000.PMID 10716355
  9. [9]Tejiram S, Shupp JW Fighting a New Front on an Old Battlefield: Examining the Development of Topical Antimicrobial Care to Control Burn Wound Sepsis. J Burn Care Res, 2025.PMID 39288163
  10. [10]Tredget EE, Shankowsky HA, Groeneveld A, et al. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil, 1998.PMID 9848045
  11. [11]Aziz Z, Abu SF, Chong NJ A systematic review of silver-containing dressings and topical silver agents (used with dressings) for burn wounds. Burns, 2012.PMID 22030441
  12. [12]Wang H, et al. Timing of surgical excision for burn wounds: A systematic evaluation and meta-analysis comparing early and delayed excision. J Int Med Res, 2026.PMID 42343617
  13. [13]Wong L, Rajandram R, Allorto N Systematic review of excision and grafting in burns: Comparing outcomes of early and late surgery in low and high-income countries. Burns, 2021.PMID 34303572
  14. [14]McManus WF, Mason AD, Pruitt BA Jr Excision of the burn wound in patients with large burns. Arch Surg, 1989.PMID 2730325
  15. [15]Fijany AJ, Givechian KB, Zago I, et al. Tranexamic acid in burn surgery: A systematic review and meta-analysis. Burns, 2023.PMID 37268542
  16. [16]Avni T, Levcovich A, Ad-El DD, et al. Prophylactic antibiotics for burns patients: systematic review and meta-analysis. BMJ, 2010.PMID 20156911
  17. [17]Pruitt BA Jr, McManus AT The changing epidemiology of infection in burn patients. World J Surg, 1992.PMID 1290268
  18. [18]Keen EF 3rd, Robinson BJ, Hospenthal DR, et al. Incidence and bacteriology of burn infections at a military burn center. Burns, 2010.PMID 20045259
  19. [19]Erol S, Altoparlak U, Akcay MN, et al. Changes of microbial flora and wound colonization in burned patients. Burns, 2004.PMID 15145194
  20. [20]Sarabahi S Changing pattern of fungal infection in burn patients. Burns, 2012.PMID 22035885
  21. [21]Olutoye OO, Eriksson E, Menchaca AD, et al. Management of Acute Wounds-Expert Panel Consensus Statement. Adv Wound Care (New Rochelle), 2024.PMID 38618741
  22. [22]Bairagi A, Griffin B, Tyack Z, et al. Comparative effectiveness of Biobrane®, RECELL® Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol. Burns Trauma, 2019.PMID 31696127
  23. [23]Lőrincz A, Váradi A, Hegyi P, et al. Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials. Life (Basel), 2022.PMID 35629287
  24. [24]Douglas H, et al. The West Australian surgical approach to massive burn injury. J Plast Reconstr Aesthet Surg, 2026.PMID 41956833

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