ICU · Infection / pharmacology

Glycopeptides & Lipopeptides — Vancomycin, Teicoplanin, Daptomycin

Also known as Glycopeptide · Vancomycin · Teicoplanin · Daptomycin · Lipopeptide · Red man syndrome · AUC over MIC · MRSA · VRE · D-alanyl-D-alanine

The glycopeptides (the vancomycin, the teicoplanin) and the lipopeptides (the daptomycin) are the Gram-positive cover — the MRSA, the MRSE, the ampicillin-resistant enterococcus, and the VRE. The glycopeptides bind the D-alanyl-D-alanine terminus, the inhibit the cell-wall synthesis; the vancomycin is the AUC-over-MIC guided (the 400 to 600) and the oral route for the C. difficile. The adverse: the red-man syndrome (the histamine, NOT the allergy, the slow the infusion), the nephrotoxicity (the vanco-plus-the-pip-tazo AKI), the ototoxicity. The daptomycin (the lipopeptide) depolarises the cell membrane (the calcium-dependent); the Gram-positive including the VRE; the INACTIVATED by the pulmonary surfactant (NOT for the pneumonia — the vancomycin for the MRSA pneumonia); the myopathy (the CPK monitoring, consider holding statin); the eosinophilic pneumonia (the rare). The teicoplanin — the once-daily, the less nephro and the less red-man than the vancomycin.

Checked against its sources on 2 Sept 2026