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ICU TopicsInfection / general

ICU · Infection / general

Fever in the ICU — Infectious or Not? The Workup & the Procalcitonin

Also known as Fever in the ICU · Pyrexia · ICU fever · Nosocomial infection · VAP · CRBSI · CAUTI · Drug fever · Central fever · Procalcitonin · Antipyresis

The fever in the ICU (the temp over 38.3) is the symptom, the not the diagnosis. The first question: the infectious or the non-infectious. The infectious (the nosocomial): the VAP, the CRBSI, the CAUTI, the SSI, the C. difficile, the sinusitis, the cholecystitis, the pressure ulcers, the primary. The non-infectious: the SIRS non-infection (the pancreatitis, the trauma, the burns, the post-op, the transfusion), the drug fever, the VTE, the malignancy, the central fever (the brain injury), the alcohol withdrawal, the adrenal insufficiency, the thyroid storm. The workup: the history and the exam (the lines, the wounds, the chest, the abdomen, the skin, the perianal, the sinuses); the cultures (the blood — the peripheral plus the EACH line lumen — the urine, the sputum, the wound); the imaging (the CXR, the CT); the markers (the CRP, the procalcitonin — the bacterial; the lactate). The management: the sepsis — the sepsis-6 within the 1 hour; the stable — the workup and the judicious the empirical antibiotics; the treat the cause; the paracetamol; the judicious the antipyresis (the fever protective in the sepsis); the active the cooling for the over 39 to 40 or the brain-injured (the TTM). The neutropenic — the empirical antibiotics the now.

high27 referencesUpdated 19 Aug 202618 min readVerification in progress

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Fever in the ICU — infectious or not?

Fever in the ICU — a core temperature above 38.3°C — is a symptom, not a diagnosis, and the question that decides everything is infectious or non-infectious? Roughly half of ICU fevers are non-infectious (drug fever, VTE, central fever, SIRS), so reflex antibiotics harm as often as they help. Hunt the source through every line, lung, wound, drain and the perianal skin; draw blood cultures from a peripheral stick AND from every central-line lumen so differential time-to-positivity can identify CRBSI; and let a procalcitonin trend guide when to start and when to stop. If sepsis is possible, deliver the sepsis-6 within the hour; if the patient is stable, work the differential first and reach for broad-spectrum cover only when the source demands it.[1]

Meet the patient

Day 5 in the unit. A 68-year-old man, intubated for severe community-acquired pneumonia, spikes a fresh 38.9°C. He has a central venous catheter in since day 2, a urinary catheter, a radial arterial line, and he is on day 5 of piperacillin-tazobactam. His lactate is normal, his vasopressors are off, and he looks comfortable — yet the mercury is climbing.[1]

The fork this vignette plants is the fork every ICU fever plants: is this a new infection — a colonised line, a ventilator-associated pneumonia, a C. difficile, a parapneumonic collection — or is it something else, like drug fever, VTE or a resolving-SIRS spike? The next three minutes at the bedside — what you examine, what you culture, and whether you reach for antibiotics — are decided by that single question. Hold it, and the rest of this page slots into place.[1]

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References27ShowHide
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  2. [2]Marik PE Fever in the ICU Chest, 2000.PMID 10713016
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  4. [4]Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Lancet, 2010.PMID 20097417
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  6. [6]Young P, Saxena M, Bellomo R, et al. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection N Engl J Med, 2015.PMID 26436473
  7. [7]Young PJ, Bellomo R, Bernard GR, Niven DJ, Schortgen F, Saxena M, et al Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials Intensive Care Med, 2019.PMID 30741326
  8. [8]Badjatia N Hyperthermia and fever control in brain injury Crit Care Med, 2009.PMID 19535955
  9. [9]Greer DM, Ritter J, Helbok R, Badjatia N, et al Impact of Fever Prevention in Brain-Injured Patients (INTREPID): Study Protocol for a Randomized Controlled Trial Neurocrit Care, 2021.PMID 33761119
  10. [10]Niven DJ, Stelfox HT, Shahpori R, Laupland KB Fever in adult ICUs: an interrupted time series analysis* Crit Care Med, 2013.PMID 23782970
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  13. [13]Mermel LA, Maki DG Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood Ann Intern Med, 1993.PMID 8328734
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  16. [16]Bréchot N, Hékimian G, Chastre J, et al Procalcitonin to guide antibiotic therapy in the ICU Int J Antimicrob Agents, 2015.PMID 26607343
  17. [17]Marik PE, Pastores SM, Annane D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force of the American College of Critical Care Medicine Crit Care Med, 2008.PMID 18496365
  18. [18]Stein PD, Afzal A, Henry JW, et al. Fever in acute pulmonary embolism Chest, 2000.PMID 10631196
  19. [19]Mackowiak PA, LeMaistre CF Drug fever: a critical appraisal of conventional concepts. An analysis of 51 episodes in two Dallas hospitals and 97 episodes reported in the English literature Ann Intern Med, 1987.PMID 3565971
  20. [20]Zhang H, Wu Y, Lin Z, et al Naproxen for the treatment of neoplastic fever: A PRISMA-compliant systematic review and meta-analysis Medicine (Baltimore), 2019.PMID 31145329
  21. [21]Hocker SE, Tian L, Li G, et al. Indicators of central fever in the neurologic intensive care unit JAMA Neurol, 2013.PMID 24100963
  22. [22]Fang X, Mo C, Zheng L, et al Transfusion-Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies Adv Sci (Weinheim), 2025.PMID 39836498
  23. [23]Cong S, Zheng G, Liang X, et al Pre-hospital cooling in community-acquired heat stroke (CAHS): evidence, challenges, and strategies Eur J Med Res, 2025.PMID 40495243
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