ICU · Infection / general
Fever in the ICU — Infectious or Not? The Workup & the Procalcitonin
Also known as Fever in the ICU · Pyrexia · ICU fever · Nosocomial infection · VAP · CRBSI · CAUTI · Drug fever · Central fever · Procalcitonin · Antipyresis
The fever in the ICU (the temp over 38.3) is the symptom, the not the diagnosis. The first question: the infectious or the non-infectious. The infectious (the nosocomial): the VAP, the CRBSI, the CAUTI, the SSI, the C. difficile, the sinusitis, the cholecystitis, the pressure ulcers, the primary. The non-infectious: the SIRS non-infection (the pancreatitis, the trauma, the burns, the post-op, the transfusion), the drug fever, the VTE, the malignancy, the central fever (the brain injury), the alcohol withdrawal, the adrenal insufficiency, the thyroid storm. The workup: the history and the exam (the lines, the wounds, the chest, the abdomen, the skin, the perianal, the sinuses); the cultures (the blood — the peripheral plus the EACH line lumen — the urine, the sputum, the wound); the imaging (the CXR, the CT); the markers (the CRP, the procalcitonin — the bacterial; the lactate). The management: the sepsis — the sepsis-6 within the 1 hour; the stable — the workup and the judicious the empirical antibiotics; the treat the cause; the paracetamol; the judicious the antipyresis (the fever protective in the sepsis); the active the cooling for the over 39 to 40 or the brain-injured (the TTM). The neutropenic — the empirical antibiotics the now.
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Day 5 in the unit. A 68-year-old man, intubated for severe community-acquired pneumonia, spikes a fresh 38.9°C. He has a central venous catheter in since day 2, a urinary catheter, a radial arterial line, and he is on day 5 of piperacillin-tazobactam. His lactate is normal, his vasopressors are off, and he looks comfortable — yet the mercury is climbing.[1]
The fork this vignette plants is the fork every ICU fever plants: is this a new infection — a colonised line, a ventilator-associated pneumonia, a C. difficile, a parapneumonic collection — or is it something else, like drug fever, VTE or a resolving-SIRS spike? The next three minutes at the bedside — what you examine, what you culture, and whether you reach for antibiotics — are decided by that single question. Hold it, and the rest of this page slots into place.[1]
References27ShowHide
- [1]O'Grady NP, Barie PS, Bartlett JG, et al. Practice guidelines for evaluating new fever in critically ill adult patients. Task Force of the Society of Critical Care Medicine and the Infectious Diseases Society of America Clin Infect Dis, 1998.PMID 9597223
- [2]Marik PE Fever in the ICU Chest, 2000.PMID 10713016
- [3]Peres Bota D, Lopes Ferreira F, Mélot C, et al. Body temperature alterations in the critically ill Intensive Care Med, 2004.PMID 15127194
- [4]Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Lancet, 2010.PMID 20097417
- [5]de Jong E, van Oers JA, Beishuizen A, Vos P, Vermeijden WJ, Haas LE, et al Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial Lancet Infect Dis, 2016.PMID 26947523
- [6]Young P, Saxena M, Bellomo R, et al. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection N Engl J Med, 2015.PMID 26436473
- [7]Young PJ, Bellomo R, Bernard GR, Niven DJ, Schortgen F, Saxena M, et al Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials Intensive Care Med, 2019.PMID 30741326
- [8]Badjatia N Hyperthermia and fever control in brain injury Crit Care Med, 2009.PMID 19535955
- [9]Greer DM, Ritter J, Helbok R, Badjatia N, et al Impact of Fever Prevention in Brain-Injured Patients (INTREPID): Study Protocol for a Randomized Controlled Trial Neurocrit Care, 2021.PMID 33761119
- [10]Niven DJ, Stelfox HT, Shahpori R, Laupland KB Fever in adult ICUs: an interrupted time series analysis* Crit Care Med, 2013.PMID 23782970
- [11]Niven DJ, Laupland KB, Tabah A, et al. Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey Crit Care, 2013.PMID 24326145
- [12]Lee A, Mirrett S, Reller LB, et al. Detection of bloodstream infections in adults: how many blood cultures are needed? J Clin Microbiol, 2007.PMID 17881544
- [13]Mermel LA, Maki DG Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood Ann Intern Med, 1993.PMID 8328734
- [14]Dhaliwal M, Daneman N Utility of Differential Time to Positivity in Diagnosing Central Line-Associated Bloodstream Infections: A Systematic Review and Meta-Analysis Clin Infect Dis, 2023.PMID 37062596
- [15]Rhee C Using Procalcitonin to Guide Antibiotic Therapy Open Forum Infect Dis, 2017.PMID 28480245
- [16]Bréchot N, Hékimian G, Chastre J, et al Procalcitonin to guide antibiotic therapy in the ICU Int J Antimicrob Agents, 2015.PMID 26607343
- [17]Marik PE, Pastores SM, Annane D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force of the American College of Critical Care Medicine Crit Care Med, 2008.PMID 18496365
- [18]Stein PD, Afzal A, Henry JW, et al. Fever in acute pulmonary embolism Chest, 2000.PMID 10631196
- [19]Mackowiak PA, LeMaistre CF Drug fever: a critical appraisal of conventional concepts. An analysis of 51 episodes in two Dallas hospitals and 97 episodes reported in the English literature Ann Intern Med, 1987.PMID 3565971
- [20]Zhang H, Wu Y, Lin Z, et al Naproxen for the treatment of neoplastic fever: A PRISMA-compliant systematic review and meta-analysis Medicine (Baltimore), 2019.PMID 31145329
- [21]Hocker SE, Tian L, Li G, et al. Indicators of central fever in the neurologic intensive care unit JAMA Neurol, 2013.PMID 24100963
- [22]Fang X, Mo C, Zheng L, et al Transfusion-Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies Adv Sci (Weinheim), 2025.PMID 39836498
- [23]Cong S, Zheng G, Liang X, et al Pre-hospital cooling in community-acquired heat stroke (CAHS): evidence, challenges, and strategies Eur J Med Res, 2025.PMID 40495243
- [24]Badjatia N, Strongilis E, Gordon E, et al Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale Stroke, 2008.PMID 18927450
- [25]Badjatia N, Strongilis E, Prescutti M, et al Metabolic benefits of surface counter warming during therapeutic temperature modulation Crit Care Med, 2009.PMID 19384208
- [26]Hoedemaekers CW, Ezzahti M, Gerritsen A, et al Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study Crit Care, 2007.PMID 17718920
- [27]Polderman KH, Rijnsburger ER, Peerdeman SM, et al Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluid Crit Care Med, 2005.PMID 16352954