ICU · Infection / pharmacology

Antivirals — Aciclovir, Oseltamivir & the Anti-COVID Agents

Also known as Antiviral · Aciclovir · Acyclovir · Valaciclovir · Ganciclovir · Valganciclovir · Foscarnet · Cidofovir · Oseltamivir · Tamiflu · Zanamivir · Peramivir · Baloxavir · Neuraminidase inhibitor · Remdesivir · Paxlovid · Nirmatrelvir · Molnupiravir · Ribavirin · Antiretroviral · ART

The antivirals in the ICU target the specific viral enzymes. The five ICU-relevant groups: the anti-herpes (the aciclovir — the HSV and the VZV; the DNA polymerase via the thymidine kinase; the NEPHROtoxicity crystal — the hydrate; the HSV encephalitis 10 mg per kg TDS for the 14 to 21 days; the ganciclovir the CMV with the bone-marrow; the foscarnet or the cidofovir the resistant with the nephrotoxic), the anti-CMV (the ganciclovir / the valganciclovir first-line for the transplant and the immunocompromised; the foscarnet and the cidofovir for the resistant or the leucopenic), the anti-influenza (the oseltamivir — the neuraminidase inhibitor; the influenza A and B; the within 48 h of the onset, the severe regardless; the reduces the duration and the complications; the prophylaxis; the zanamivir inhaled, the peramivir IV, the baloxavir the cap-dependent endonuclease), the anti-SARS-CoV-2 (the remdesivir — the RNA polymerase, the severe COVID; the Paxlovid — the nirmatrelvir or the ritonavir protease inhibitor, the early high-risk; the molnupiravir), and the anti-HIV / the ART (the combination antiretroviral therapy — the two NRTIs plus an integrase inhibitor; the ICU the drug-interaction burden, the lactic acidosis, the IRIS, the abacavir hypersensitivity). The renal dosing the critical (the aciclovir, the ganciclovir, the oseltamivir all renally cleared).

Checked against its sources on 2 Sept 2026