ICU SAQs · Post-cardiac arrest care
TTM2 — hypothermia versus normothermia after cardiac arrest
A CICM Second-Part SAQ on TTM2 (Dankiewicz NEJM 2021) — hypothermia at 33 degrees NOT superior to normothermia (37.5 degrees with fever avoidance); the practice has changed to strict normothermia.
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Prompt
Critically appraise the TTM2 trial. What did it show, and how has it changed the practice of the targeted temperature management after the cardiac arrest?
Question
Critically appraise the TTM2 trial. What did it show, and how has it changed the practice of the targeted temperature management after the cardiac arrest?
[2]References2ShowHide
- [1]Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2). New England Journal of Medicine, 2021.PMID 34133859
- [2]Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. New England Journal of Medicine, 2013.PMID 24237006